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Understanding genetic variation, e.g., through mutations, in organisms is crucial to unravel their effects on the environment and human health. A fundamental characterization can be obtained by solving the haplotype assembly problem, which…

基因组学 · 定量生物学 2022-10-25 Hansheng Xue , Vaibhav Rajan , Yu Lin

In many causal inference applications, only one or a few units (or clusters of units) are treated. An important challenge in such settings is that standard inference methods relying on asymptotic theory may be unreliable, even with large…

计量经济学 · 经济学 2026-05-22 Luis Alvarez , Bruno Ferman , Kaspar Wüthrich

In recent years, a plethora of new metaheuristic algorithms have explored different sources of inspiration within the biological and natural worlds. This nature-inspired approach to algorithm design has been widely criticised. A notable…

神经与进化计算 · 计算机科学 2020-03-26 Michael Adam Lones

Metaheuristics are widely recognized gradient-free solvers to hard problems that do not meet the rigorous mathematical assumptions of conventional solvers. The automated design of metaheuristic algorithms provides an attractive path to…

神经与进化计算 · 计算机科学 2025-04-08 Qi Zhao , Bai Yan , Taiwei Hu , Xianglong Chen , Jian Yang , Shi Cheng , Yuhui Shi

Diffusion Models represent a significant advancement in generative modeling, employing a dual-phase process that first degrades domain-specific information via Gaussian noise and restores it through a trainable model. This framework enables…

神经与进化计算 · 计算机科学 2024-11-21 Benedikt Hartl , Yanbo Zhang , Hananel Hazan , Michael Levin

Despite being among the most common psychological disorders, anxiety-related conditions are still primarily identified through subjective assessments, such as clinical interviews and self-evaluation questionnaires. These conventional…

计算机视觉与模式识别 · 计算机科学 2025-11-25 Mohammadreza Amiri , Monireh Hosseini

Bayesian optimal experimental design has immense potential to inform the collection of data so as to subsequently enhance our understanding of a variety of processes. However, a major impediment is the difficulty in evaluating optimal…

统计计算 · 统计学 2018-03-14 David J. Price , Nigel G. Bean , Joshua V. Ross , Jonathan Tuke

Feature selection is a problem of finding efficient features among all features in which the final feature set can improve accuracy and reduce complexity. In feature selection algorithms search strategies are key aspects. Since feature…

机器学习 · 计算机科学 2016-01-27 Mohadeseh Montazeri , Hamid Reza Naji , Mitra Montazeri , Ahmad Faraahi

In the genomic era, the identification of gene signatures associated with disease is of significant interest. Such signatures are often used to predict clinical outcomes in new patients and aid clinical decision-making. However, recent…

统计方法学 · 统计学 2019-03-27 Naim U. Rashid , Quefeng Li , Jen Jen Yeh , Joseph G. Ibrahim

Typing methods are widely used in the surveillance of infectious diseases, outbreaks investigation and studies of the natural history of an infection. And their use is becoming standard, in particular with the introduction of High…

数据结构与算法 · 计算机科学 2020-06-16 Cátia Vaz , Marta Nascimento , João A. Carriço , Tatiana Rocher , Alexandre P. Francisco

Weather forecasting plays a vital role in numerous sectors, but accurately capturing the complex dynamics of weather systems remains a challenge for traditional statistical models. Apart from Auto Regressive time forecasting models like…

神经与进化计算 · 计算机科学 2023-11-27 Anuvab Sen , Arul Rhik Mazumder , Dibyarup Dutta , Udayon Sen , Pathikrit Syam , Sandipan Dhar

Metagenomics provides a powerful new tool set for investigating evolutionary interactions with the environment. However, an absence of model-based statistical methods means that researchers are often not able to make full use of this…

定量方法 · 定量生物学 2013-06-27 John O'Brien , Xavier Didelot , Zamin Iqbal , LucasAmenga-Etego , Bartu Ahiska , Daniel Falush

Convex optimization encompasses a wide range of optimization problems that contain many efficiently solvable subclasses. Interior point methods are currently the state-of-the-art approach for solving such problems, particularly effective…

最优化与控制 · 数学 2025-03-28 Andreas Klingler , Tim Netzer

In this paper, the efficient hinging hyperplanes (EHH) neural network is proposed based on the model of hinging hyperplanes (HH). The EHH neural network is a distributed representation, the training of which involves solving several convex…

系统与控制 · 计算机科学 2019-11-28 Jun Xu , Qinghua Tao , Zhen Li , Xiangming Xi , Johan A. K. Suykens , Shuning Wang

Path planning is typically considered in Artificial Intelligence as a graph searching problem and R* is state-of-the-art algorithm tailored to solve it. The algorithm decomposes given path finding task into the series of subtasks each of…

人工智能 · 计算机科学 2015-11-04 Konstantin Yakovlev , Egor Baskin , Ivan Hramoin

Heuristic search algorithms, e.g. A*, are the commonly used tools for pathfinding on grids, i.e. graphs of regular structure that are widely employed to represent environments in robotics, video games etc. Instance-independent heuristics…

人工智能 · 计算机科学 2022-12-23 Daniil Kirilenko , Anton Andreychuk , Aleksandr Panov , Konstantin Yakovlev

Metaheuristics have gained great success in academia and practice because their search logic can be applied to any problem with available solution representation, solution quality evaluation, and certain notions of locality. Manually…

神经与进化计算 · 计算机科学 2024-02-22 Qi Zhao , Qiqi Duan , Bai Yan , Shi Cheng , Yuhui Shi

Combinatorial optimization is widely applied in a number of areas nowadays. Unfortunately, many combinatorial optimization problems are NP-hard which usually means that they are unsolvable in practice. However, it is often unnecessary to…

数据结构与算法 · 计算机科学 2012-07-10 Daniel Karapetyan

We develop a model-based methodology for integrating gene-set information with an experimentally-derived gene list. The methodology uses a previously reported sampling model, but takes advantage of natural constraints in the…

统计方法学 · 统计学 2015-06-02 Zhishi Wang , Qiuling He , Bret Larget , Michael A. Newton

Backtracking search algorithms are often used to solve the Constraint Satisfaction Problem (CSP). The efficiency of backtracking search depends greatly on the variable ordering heuristics. Currently, the most commonly used heuristics are…

人工智能 · 计算机科学 2021-12-28 Wen Song , Zhiguang Cao , Jie Zhang , Andrew Lim