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Models of biological systems often have many unknown parameters that must be determined in order for model behavior to match experimental observations. Commonly-used methods for parameter estimation that return point estimates of the…

定量方法 · 定量生物学 2018-01-31 Sanjana Gupta , Liam Hainsworth , Justin S. Hogg , Robin E. C. Lee , James R. Faeder

Bayesian inference provides a methodology for parameter estimation and uncertainty quantification in machine learning and deep learning methods. Variational inference and Markov Chain Monte-Carlo (MCMC) sampling methods are used to…

机器学习 · 统计学 2024-08-27 Rohitash Chandra , Joshua Simmons

This paper is on Bayesian inference for parametric statistical models that are defined by a stochastic simulator which specifies how data is generated. Exact sampling is then possible but evaluating the likelihood function is typically…

机器学习 · 统计学 2020-03-02 Borislav Ikonomov , Michael U. Gutmann

Markov chain Monte Carlo (MCMC) is a simulation method commonly used for estimating expectations with respect to a given distribution. We consider estimating the covariance matrix of the asymptotic multivariate normal distribution of a…

统计方法学 · 统计学 2017-06-06 Ning Dai , Galin L. Jones

Markov chain Monte Carlo (MCMC) has transformed Bayesian model inference over the past three decades: mainly because of this, Bayesian inference is now a workhorse of applied scientists. Under general conditions, MCMC sampling converges…

统计方法学 · 统计学 2020-11-20 Ben Lambert , Aki Vehtari

Leaving posterior sensitivity concerns aside, non-identifiability of the parameters does not raise a difficulty for Bayesian inference as far as the posterior is proper, but multi-modality or flat regions of the posterior induced by the…

计量经济学 · 经济学 2025-12-22 Toru Kitagawa , Yizhou Kuang

Markov chain Monte Carlo methods are often deemed too computationally intensive to be of any practical use for big data applications, and in particular for inference on datasets containing a large number $n$ of individual data points, also…

统计方法学 · 统计学 2015-05-13 Rémi Bardenet , Arnaud Doucet , Chris Holmes

A Bayesian coreset is a small, weighted subset of data that replaces the full dataset during inference in order to reduce computational cost. However, state of the art methods for tuning coreset weights are expensive, require nontrivial…

统计计算 · 统计学 2024-03-12 Naitong Chen , Trevor Campbell

This paper addresses the problem of estimating the Potts parameter B jointly with the unknown parameters of a Bayesian model within a Markov chain Monte Carlo (MCMC) algorithm. Standard MCMC methods cannot be applied to this problem because…

统计计算 · 统计学 2015-06-05 Marcelo Pereyra , Nicolas Dobigeon , Hadj Batatia , Jean-Yves Tourneret

In this paper we consider the parameter estimation problem associated to partially-observed time changed SDEs, with observations that are given at discrete times. In particular we consider both likelihood and Bayesian estimation. We develop…

数值分析 · 数学 2026-05-12 Ke Zhao , Ajay Jasra

Likelihood-free methods, such as approximate Bayesian computation, are powerful tools for practical inference problems with intractable likelihood functions. Markov chain Monte Carlo and sequential Monte Carlo variants of approximate…

统计计算 · 统计学 2019-02-26 David J. Warne , Ruth E. Baker , Matthew J. Simpson

Metropolis-Hastings (MH) is a foundational Markov chain Monte Carlo (MCMC) algorithm. In this paper, we ask whether it is possible to formulate and analyse MH in terms of categorical probability, using a recent involutive framework for…

统计计算 · 统计学 2026-02-02 Rob Cornish , Andi Q. Wang

Markov chain Monte Carlo (MCMC) algorithms have become powerful tools for Bayesian inference. However, they do not scale well to large-data problems. Divide-and-conquer strategies, which split the data into batches and, for each batch, run…

统计计算 · 统计学 2017-07-18 Christopher Nemeth , Chris Sherlock

Decision trees are commonly used predictive models due to their flexibility and interpretability. This paper is directed at quantifying the uncertainty of decision tree predictions by employing a Bayesian inference approach. This is…

机器学习 · 计算机科学 2024-03-28 Jodie A. Cochrane , Adrian Wills , Sarah J. Johnson

Markov Chain Monte Carlo (MCMC) methods are a powerful tool for computation with complex probability distributions. However the performance of such methods is critically dependant on properly tuned parameters, most of which are difficult if…

统计计算 · 统计学 2021-10-27 James A. Brofos , Marylou Gabrié , Marcus A. Brubaker , Roy R. Lederman

We propose a flexible prior model for the parameters of binary Markov random fields (MRF) defined on rectangular lattices and with maximal cliques defined from a template maximal clique. The prior model allows higher-order interactions to…

统计方法学 · 统计学 2015-01-20 Petter Arnesen , Håkon Tjelmeland

We present a comprehensive comparison of different Markov Chain Monte Carlo (MCMC) sampling methods, evaluating their performance on both standard test problems and cosmological parameter estimation. Our analysis includes traditional…

宇宙学与河外天体物理 · 物理学 2025-02-28 Denitsa Staicova

In large-scale genomic applications vast numbers of molecular features are scanned in order to find a small number of candidates which are linked to a particular disease or phenotype. This is a variable selection problem in the "large p,…

统计计算 · 统计学 2014-02-13 Manuela Zucknick , Sylvia Richardson

Latent class analysis is used to perform model based clustering for multivariate categorical responses. Selection of the variables most relevant for clustering is an important task which can affect the quality of clustering considerably.…

统计计算 · 统计学 2016-06-17 Arthur White , Jason Wyse , Thomas Brendan Murphy

This paper presents an improved implicit sampling method for hierarchical Bayesian inverse problems. A widely used approach for sampling posterior distribution is based on Markov chain Monte Carlo (MCMC). However, the samples generated by…

数值分析 · 数学 2018-11-27 Xiaoyan Song , Lijian Jiang , Guanghui Zheng