定量生物学

This case details the diagnosis and treatment process of a patient with bilateral facial nerve palsy accompanied with limb sensory disturbance secondary to head trauma, who was ultimately diagnosed with Bifacial weakness with paresthesias…

Brain age prediction serves as a powerful framework for assessing brain status and detecting deviations associated with neurodevelopmental and neurodegenerative disorders. However, most existing approaches emphasize whole-brain age…

The evolution of biological morphology is critical for understanding the diversity of the natural world, yet traditional analyses often involve subjective biases in the selection and coding of morphological traits. This study employs deep…

Background: Single-stranded whole-genome bisulfite sequencing (ssWGBS) enables DNA methylation profiling in low-input and highly fragmented material, including cell-free DNA. In widely used post-bisulfite protocols, Adaptase-mediated…

We analyze continuous Hopfield associative memories augmented by additional, rapid short-term associative synaptic plasticity. Through the cavity method, we determine the boundary between the retrieval and forgetting, or spin-glass phase,…

Cell type annotation is a fundamental step in the analysis of single-cell RNA sequencing (scRNA-seq) data. In practice, human experts often rely on the structure revealed by principal component analysis (PCA) followed by $k$-nearest…

Fear is a critical brain function that enables us to learn to avoid danger via reinforcement learning (RL). While many researchers have argued that fear has evolved to escape predators, how varying predatory pressures have shaped fear and…

The idea that information-processing systems operate near criticality to enhance computational performance is supported by scaling signatures in brain activity. However, external signals raise the question of whether this behavior is…

Now published in Nature Communications DOI: https://doi.org/10.1038/s41467-026-69345-9 Large-scale visual neural datasets such as the Natural Scenes Dataset (NSD) are boosting computational neuroscience research by enabling models of the…

We propose a probabilistic framework for developing computational models of biological neural systems. In this framework, physiological recordings are viewed as discrete-time partial observations of an underlying continuous-time stochastic…

Modern computational organic chemistry is becoming increasingly data-driven. There remain a large number of important unsolved problems in this area such as product prediction given reactants, drug discovery, and metric-optimized molecule…

We present a model for a threshold-based resource redistribution process in a spatially-explicit population, characterizing the relation between kinship network structure, local interactions and persistence. We find that population survival…

Detecting chemical modifications on RNA molecules remains a key challenge in epitranscriptomics. Traditional reverse transcription-based sequencing methods introduce enzyme- and sequence-dependent biases and fragment RNA molecules,…

Traditional non-biological storage media, such as hard drives, face limitations in both storage density and lifespan due to the rapid growth of data in the big data era. Mirror-image peptides composed of D-amino acids have emerged as a…

The emerging field of epigenetics has recently unveiled a dynamic landscape in which gene expression is not determined solely by genetic sequences but also by intricate regulatory mechanisms. This review examines the interactions between…

This paper introduces several proof-of-concept (PoC) computational methods intended to offer biochemical researchers straightforward, time- and cost-effective strategies to accelerate their work. While Machine Learning (ML) models were…

Vegetation in semi-arid ecosystems frequently organizes into spatially heterogeneous mosaics that regulate ecosystem functioning, productivity, and resilience. These patterns arise from local biological interactions, including facilitation…

We introduce several axioms which may or may not hold for any given subgraph of the directed graph of all organisms (past, present and future) where edges represent biological parenthood, with the simplifying background assumption that life…

The relationship between traits that influence pathogen virulence and transmission is part of the central canon of the evolution and ecology of infectious disease. However, identifying directional and mechanistic relationships among traits…

The tumor-immune system plays a critical role in colorectal cancer progression. Recent preclinical and clinical studies showed that combination therapy with anti-PD-L1 and cancer vaccines improved treatment response. In this study, we…