定量生物学
Recurrence plots and their associated quantifiers provide a robust framework for detecting and characterising complex patterns in non-linear time-series. In this paper, we employ recurrence quantification analysis to investigate the…
Biostasis has the potential to extend human lives by offering a bridge to powerful life extension technologies that may be developed in the future. However, key questions in the field remain unresolved, including which biomarkers reliably…
The hypothalamus plays an important role in the regulation of the bodys metabolic state and behaviors related to survival. Despite its importance however, many questions exist regarding the intrinsic and extrinsic connections of the…
Triple-negative breast cancer (TNBC) remains a major clinical challenge due to its aggressive behavior and lack of targeted therapies. Accurate early prediction of response to neoadjuvant chemotherapy (NACT) is essential for guiding…
Inverse protein folding generates valid amino acid sequences that can fold into a desired protein structure, with recent deep-learning advances showing strong potential and competitive performance. However, challenges remain, such as…
Variant calling is a fundamental task in genomic research, essential for detecting genetic variations such as single nucleotide polymorphisms (SNPs) and insertions or deletions (indels). This paper presents an enhancement to DeepChem, a…
In a previous paper, we have shown that an ontology of quantum mechanics in terms of states and events with internal phenomenal aspects, that is, a form of panprotopsychism, is well suited to explaining the phenomenal aspects of…
While enforcing egalitarian social norms is critical for human society, punishing social norm violators often incurs a cost to the self. This cost looms even larger when one can benefit from an unequal distribution of resources (i.e.…
Ribosome-targeting antibiotics, such as chloramphenicol, stall elongating ribosomes during protein synthesis, disrupting mRNA translation. These antibiotic-induced pauses occur stochastically, alter collective ribosome dynamics and…
Traditional drug discovery relies on rounds of screening millions of candidate molecules with low success rates, making drug discovery time and resource intensive. To overcome this screening bottleneck, we introduce Latent-X, an all-atom…
We describe the design and implementation of two low-cost, low-weight, radiotelemetry systems to measure the movement of small animals in a dense forest, where satellite positioning systems are unreliable and the attenuation of the…
Macrophages play an essential role in wound healing due to their dynamic nature and functional plasticity, exhibiting highly heterogeneous morpho-kinetic behaviors depending on their activation states. However, quantitative analysis of…
Preclinical models of neurodevelopmental and psychiatric conditions often rely on inbred mouse strains like C57BL/6J (B6), which exhibit limited genetic and behavioral variability. This limitation hampers the modeling of phenotypic…
Drug-drug interactions (DDIs) arise when multiple drugs are administered concurrently. Accurately predicting the specific mechanisms underlying DDIs (named DDI events or DDIEs) is critical for the safe clinical use of drugs. DDIEs are…
The emergence of spatial patterns and organized growth is a hallmark of developing tissues. While symmetry-breaking and scaling laws govern these processes, how cells coordinate spatial patterning with size regulation remains unclear. Here,…
Background: Colorectal adenocarcinoma (CRC) remains a leading cause of cancer-related mortality worldwide, with variable patient outcomes despite treatment advances. Traditional prognostic methods based on clinicopathological variables…
Breast cancer is a significant global health issue, and the diagnosis of breast cancer through imaging remains challenging. Mammography images are characterized by extremely high resolution, while lesions often occupy only a small portion…
Reconstructing the attractors of complex nonlinear dynamical systems from available measurements is key to analyse and predict their time evolution. Existing attractor reconstruction methods typically rely on topological embedding and may…
As humanity prepares for sustained off-world habitation, the development of regolith-based agriculture (RBA) is essential for achieving self-sufficiency in space crop production. However, lunar regolith's alkaline pH, poor water retention,…
The integration of plant-based bioregenerative life support systems is a central objective in NASA's Moon to Mars strategy. Arabidopsis thaliana, a model organism with extensive genomic resources, serves as a key species to investigate…