定量生物学
A common assumption in evolutionary thought is that adaptation drives an increase in biological complexity. However, the rules governing evolution of complexity appear more nuanced. Evolution is deeply connected to learning, where…
The human brain is organized as a complex network, where connections between regions are characterized by both functional connectivity (FC) and structural connectivity (SC). While previous studies have primarily focused on network-level…
Pan-cancer classification using transcriptomic (RNA-Seq) data can inform tumor subtyping and therapy selection, but is challenging due to extremely high dimensionality and limited sample sizes. In this study, we propose a novel deep…
Understanding the stoichiometry and associated stability of virus-like particles (VLPs) is crucial for optimizing their assembly efficiency and immunogenic properties, which are essential for advancing biotechnology, vaccine design, and…
The aim of this paper is to present an, admittedly somewhat subjective, bird's eye view of the mathematical theory concerning the spread of an infectious disease in a susceptible host population with static structure, culminating in a…
Attention is not monolithic; rather, it operates in multiple forms to facilitate efficient cognitive processing. In the auditory domain, attention enables the prioritization of relevant sounds in an auditory scene and can be either…
Motion is an important feature of visual scenes and retinal neuronal circuits selectively signal different motion features. It has been shown that the retina can extrapolate the position of a moving object, thereby compensating sensory…
Histopathological analysis has been transformed by serial section-based methods, advancing beyond traditional 2D histology to enable volumetric and microstructural insights in oncology and inflammatory disease diagnostics. This review…
We demonstrate that combining machine learning with data assimilation leads to a major improvement in phytoplankton short-range (1-5 day) forecasts for the North-West European Shelf (NWES) seas. We show that excess nitrate concentrations…
Using simulation and a simple mathematical argument we argue that the refresh rate of overhead projectors, used in experiments on the visual system, may impact the perception of fast moving objects at the retinal and cortical level (V1),…
Accurate reconstruction of neuronal morphology is essential for classifying cell types and understanding brain connectivity. Recent advances in imaging and reconstruction techniques have greatly expanded the scale and quality of neuronal…
Protein surface fingerprint encodes chemical and geometric features that govern protein-protein interactions and can be used to predict changes in binding affinity between two protein complexes. Current state-of-the-art models for…
Endothelial cells release various vasorelaxing molecules, such as nitric oxide and prostacyclin, along with defined factors that induce hyperpolarization of vascular smooth muscle cells through the opening of calcium-sensitive potassium…
This paper develops and analyzes a diffusion-advection model coupling population dynamics with toxicant transport, incorporating a boundary protection zone. For both upstream and downstream protection zone configurations, we investigate the…
The purpose of this study was to investigate how the entropy of a neuron cell can be measured using membrane ion current signals, which were recorded from neurons in the mouse medial prefrontal cortex (mPFC). The sample entropy and the…
This study builds upon our previously proposed stochastic differential equation (SDE)-based model to further investigate fish school fragmentation under predation. Specifically, we explore structural dynamics by incorporating…
Understanding the dynamics of antibody levels is crucial for characterizing the time-dependent response to immune events: either infections or vaccinations. The sequence and timing of these events significantly influence antibody level…
Clustering patient subgroups is essential for personalized care and efficient resource use. Traditional clustering methods struggle with high-dimensional, heterogeneous healthcare data and lack contextual understanding. This study evaluates…
Since the turn of the millennium, computational modelling of biological systems has evolved remarkably and sees matured use spanning basic and clinical research. While the topic of the peri-millennial debate about the virtues and…
Many mathematical models of synaptic plasticity have been proposed to explain the diversity of plasticity phenomena observed in biological organisms. These models range from simple interpretations of Hebb's postulate, which suggests that…