医学物理
Prostate cancer (PCa) is the second most common cancer in men worldwide and the most frequently diagnosed cancer among men in more developed countries. The prognosis of PCa is excellent if detected at an early stage, making early screening…
The quantification of liver fat as a diagnostic assessment of steatosis remains an important priority for noninvasive imaging systems. We derive a framework in which the unknown fat volume percentage can be estimated from a pair of…
Optical coherence tomography angiography (OCTA) has been established as a powerful tool for investigating vascular diseases and is expected to become a standard of care technology. However, its widespread clinical usage is hindered by…
To rapidly obtain high resolution T2, T2* and quantitative susceptibility mapping (QSM) source separation maps with whole-brain coverage and high geometric fidelity. We propose Blip Up-Down Acquisition for Spin And Gradient Echo imaging…
It is often accepted a priori that a face mask worn by an infected subject is effective to avoid the spreading of a respiratory disease, while a healthy person is not necessarily well protected when wearing the mask. Using a frugal stain…
Accurate characterization of in utero human brain maturation is critical as it involves complex and interconnected structural and functional processes that may influence health later in life. Magnetic resonance imaging is a powerful tool to…
In winter of 2020, SARS-CoV-2 emerged as a global threat, impacting not only health but also financial and political stability. To address the societal need for monitoring the spread of SARS-CoV-2, many existing diagnostic technologies were…
Multi-nuclear radio-frequency (RF) coils at ultrahigh field strengths are challenging to develop due to the high operating frequency, increased electromagnetic interaction among the coil elements, and increased electromagnetic interaction…
Purpose: We propose a general framework for quantifying predictive uncertainties of dose-related quantities and leveraging this information in a dose mimicking problem in the context of automated radiation therapy treatment planning.…
We present a method of directly optimizing on deviations in clinical goal values in radiation therapy treatment planning. Using a new mathematical framework in which metrics derived from the dose-volume histogram are regarded as functionals…
By decoupling motion and spatial encoding, magnitude contrast MR Elastography could be performed for the first time at ultrashort echo times (12 $\mu$s). On the basis of a motion-sensitizing magnetization preparation, the available total…
The head down tilt (HDT) position is commonly used to simulate vascular and tissue fluid dynamics during spaceflights. In HDT position, the cerebral autoregulation faces difficulties to adjust the vascular tone while the cephalad fluid…
In the framework of algebraic inversion, Magnetic Resonance Elastography (MRE) repeatability, reproducibility and robustness were evaluated on extracted shear velocities (or elastic moduli). The same excitation system was implemented at two…
Personal protective clothing is critical to shield users from highly infectious diseases including COVID-19. Such clothing is predominantly single-use, made of plastic-based synthetic fibres such as polypropylene and polyester, low cost and…
The shear strength and the corrosion resistance of the fiber/matrix interface after immersion in simulated body fluid was studied in poly-lactic acid/Mg fiber composites. The shear strength of the interface was measured by means of push-out…
Digital analysis of mammographic images is a complementary tool to clinical evaluation, commonly used to identify tumors and/or microcalcifications in mammograms. Recent mammographic equipment, can automatically classify them using this…
Purpose: Recent studies suggest ultra-high dose rate (FLASH) irradiation can spare normal tissues from radiotoxicity, while efficiently controlling the tumor, and this is known as the FLASH effect. This study performed theoretical analyses…
We present an open-source platform to aid medical dosimetrists in preventing collisions between gantry head and patient or couch during photon or particle beam therapy treatment planning. This generic framework uses the native scripting…
Dose painting of hypoxic tumour sub-volumes using positron-emission tomography (PET) has been shown to improve tumour control in silico in several sites. Pancreatic cancer presents a more stringent challenge, given its proximity to critical…
We explore the application of concepts developed in High Energy Physics (HEP) for advanced medical data analysis. Our study case is a problem with high social impact: clinically-feasible Magnetic Resonance Fingerprinting (MRF). MRF is a…