医学物理
We demonstrate multiplexed computational sensing with a point-of-care serodiagnosis assay to simultaneously quantify three biomarkers of acute cardiac injury. This point-of-care sensor includes a paper-based fluorescence vertical flow assay…
Radiation-induced acoustic (RA) imaging is a promising technique for visualizing radiation energy deposition in tissues, enabling new imaging modalities and real-time therapy monitoring. However, it requires measuring hundreds or even…
Plasmodium spp. are the protozoan parasites responsible for malaria. Plasmodium spp. synthesise a biocrystal, hemozoin, which can be observed under cross-polarised light. These birefringent crystals can be seen due to different refractive…
Collagen crosslinking of the cornea (CXL) is commonly employed to prevent or treat keratoconus. Although the change of corneal stiffness induced by CXL surgery can be monitored with non-contact dynamic Optical Coherence Elastography (OCE)…
The ability to perceive polarization-related entoptic phenomena arises from the dichroism of macular pigments held in Henle's fiber layer of the retina and can be inhibited by retinal diseases such as age-related macular degeneration, which…
X-Ray based computed tomography (CT) is a well-established technique for determining the three-dimensional structure of an object from its two-dimensional projections. In the past few decades, there have been significant advancements in the…
Filtering based on Singular Value Decomposition (SVD) provides substantial separation of clutter, flow and noise in high frame rate ultrasound flow imaging. The use of SVD as a clutter filter has greatly improved techniques such as vector…
Recent research shows the eye has a paravascular solute transport pathway driven by physiological pulsations resembling the brain. we developed synchronous multimodal imaging tools aimed at measuring the driving pulsations of the human eye.…
Objective: We investigate and develop optimization-based algorithms for accurate reconstruction of four-dimensional (4D)-spectral-spatial (SS) images directly from data collected over limited angular ranges (LARs) in continuous-wave (CW)…
PURPOSE: To update and extend version 2 of the Carleton Laboratory for Radiotherapy Physics (CLRP) TG-43 dosimetry database (CLRP_TG43v2) for 33 high-energy (HE, $\geq50$~keV) brachytherapy sources using egs_brachy, an open-source EGSnrc…
Delineating and planning with respect to regions suspected to contain microscopic tumor cells is an inherently uncertain task in radiotherapy. The recently proposed \textit{clinical target distribution} (CTD) is an alternative to the…
Purpose: This study aimed to use deep learning-based dose prediction to assess head and neck (HN) plan quality and identify suboptimal plans. Methods: A total of 245 VMAT HN plans were created using RapidPlan knowledge-based planning (KBP).…
Diffuse low grade gliomas are invasive and incurable brain tumours that inevitably transform into higher grade ones. A classical treatment to delay this transition is radiotherapy (RT). Following RT, the tumour gradually shrinks during a…
Background: Recently, the reaction $^{nat}$V($\alpha$,x)$^{52g}$Mn has been proposed as a possible alternative to the standard $^{nat}$Cr($p$,x)$^{52g}$Mn one, but improvements in the modeling were needed to better compare the two…
The fastMRI brain and knee dataset has enabled significant advances in exploring reconstruction methods for improving speed and image quality for Magnetic Resonance Imaging (MRI) via novel, clinically relevant reconstruction approaches. In…
Over the past two decades there has been a steady trend towards the development of realistic models of cardiac conduction with increasing levels of detail. However, making models more realistic complicates their personalization and use in…
In recent years, cold atmospheric plasma (CAP) using inert gas has been successfully applied for biomedicine, such as sterilization, wound healing, skin diseases, and tumor treatment. Here, we reported air cold atmospheric plasma with three…
Microscopy plays a crucial role in hematology and diagnosis of infectious diseases worldwide. For malaria alone, more than 200 million slides are read by manual microscopists every year. High quality thin blood smears are essential for…
Recent advances in high-resolution biomedical imaging focusing on morphological, electrical, and biochemical properties of cells and tissues, scaling from cell clusters down to the molecular level, have improved cancer diagnosis. Multiscale…
Purpose:The recently proposed IPO-IMPT framework allows simultaneous optimization of dose, dose rate, and LET for FLASH treatment planning. Finding solutions to IPO-IMPT is difficult due to computational intensiveness. Nevertheless, an…