生物物理
This review article provides a specific example of recombinant cell and protocell technology, moving from what is presently known to suggesting how novel application of existing methodologies could be utilized to design a complex synthetic…
Intrinsically disordered proteins (IDPs) abound in cellular regulation. Their interactions are often transitory and highly sensitive to salt concentration and posttranslational modifications. However, little is known about the effect of…
We conduct a systematic,direct-numerical-simulation study,in mathematical models for ventricular tissue,of the dependence of spiral-and scroll-wave dynamics on $G_{Kr}$, the maximal conductance of the delayed rectifier Potassium…
The morphology of spherically confined flexoelectric fluid membrane vesicles in an external uniform electric field is studied numerically. Due to the deformations induced by the confinement, the membrane becomes polarized resulting in an…
The persistent motility of the individual constituents in microbial suspensions represents a prime example of so-called active matter systems. Cells consume energy, exert forces and move, overall releasing the constraints of equilibrium…
A growing body of evidence suggests that the structure of mitochondrial networks is poised near criticality, an intermediate regime lying in between order and disorder. Such description fits well with the idea that biological systems, in…
Many biomolecules have flexible structures, requiring distributional estimates of their conformations. Experiments to acquire distributional data typically measure pairs of labels separately, losing information on the joint distribution.…
An explicitly solvable model of sound sources detection and sound wave scattering by the lateral line of a fish or amphibian based on the theory of self-adjoint perturbations of the Laplace operator by arrays of additional boundary…
We present a minimal model to study liquid phase separation in a fixed pH ensemble. The model describes a mixture composed of macromolecules that exist in three different charge states and have a tendency to phase separate. We introduce the…
When pollen grains become exposed to the environment, they rapidly desiccate. To protect themselves until rehydration, the grains undergo characteristic infolding with the help of special structures in the grain wall---apertures---where the…
The applications of terahertz (THz) radiation for plant water status monitoring require systematic studies on interaction of THz wave and plants. Here, we present theoretical investigations on scattering behavior of THz waves reflected by…
Protein motions occur on multiple time and distance scales. Large-scale motions of protein tertiary-structure elements, i.e. domains, are particularly intriguing as they are essential for the catalytic activity of many enzymes and for the…
Biological microfilaments exhibit a variety of synchronization modes. Recent experiments observed that a pair of isolated eukaryotic flagella, coupled solely via the fluid medium, display synchrony at nontrivial phase-lags in addition to…
Prion diseases are associated with the misfolding of the normal helical cellular form of prion protein (PrPC) into the beta-sheet-rich scrapie form (PrPSc) and the subsequent aggregation of PrPSc into amyloid fibrils. Recent studies…
Computational determination of the equilibrium state of heterogeneous phospholipid mem-branes is a significant challenge. We wish to explore the rich phase diagram of these multi-component systems. However, the diffusion and mixing times in…
Social hierarchy is central to decision-making in the coordinated movement of many swarming species. Here we propose a hierarchical swarm model in the spirit of the Vicsek model of self-propelled particles. We show that, as the hierarchy…
Living cells exhibit multi-mode transport that switches between an active, self-propelled motion and a seemingly passive, random motion. Cellular decision-making over transport mode switching is a stochastic process that depends on the…
The structure of DNA double helix is stabilized by metal counterions condensed to a diffuse layer around the macromolecule. The dynamics of counterions in real conditions is governed by the electric fields from DNA and other biological…
Cell migration is an indispensable physiological and pathological process for normal tissue development and cancer metastasis, which is greatly regulated by intracellular signal pathways and extracellular microenvironment (ECM). However,…
Interruptions in nonlinear wave propagation, commonly referred to as wave breaks, are typical of many complex excitable systems. In the heart they lead to fatal rhythm disorders, the so-called arrhythmias, which are one of the main causes…