DNA Segmentation as A Model Selection Process
摘要
Previous divide-and-conquer segmentation analyses of DNA sequences do not provide a satisfactory stopping criterion for the recursion. This paper proposes that segmentation be considered as a model selection process. Using the tools in model selection, a limit for the stopping criterion on the relaxed end can be determined. The Bayesian information criterion, in particular, provides a much more stringent stopping criterion than what is currently used. Such a stringent criterion can be used to delineate larger DNA domains. A relationship between the stopping criterion and the average domain size is empirically determined, which may aid in the determination of isochore borders.
关键词
引用
@article{arxiv.physics/0104027,
title = {DNA Segmentation as A Model Selection Process},
author = {Wentian Li},
journal= {arXiv preprint arXiv:physics/0104027},
year = {2007}
}
备注
7 pages, 4 figures, Proceedings of the Fifth Annual International Conference of Computational Molecular Biology (RECOMB 2001), to appear