方解石单晶作为原子尺度药物包埋与缓释的载体
材料科学
2020-02-17 v1
摘要
本研究对作为 pH 响应型药物载体的阿霉素-CaCO 单晶进行了完整的结构与生物学表征。采用仿生方法证明，方解石单晶在生长过程中若有阿霉素存在，能够沿特定晶体学方向将药物分子包埋于其晶格内部。高分辨率同步辐射粉末衍射测量确定了晶格畸变和微观结构参数。共聚焦显微镜证实阿霉素均匀嵌入晶体内部，而不仅仅吸附在晶体表面。获得了阿霉素的缓慢释放，且释放优先发生在晶体附近，从而靶向癌细胞。
引用
@article{arxiv.1609.05462,
title = {Calcite single crystals as hosts for atomic-scale entrapment and slow release of drugs},
author = {Giulia Magnabosco and Matteo Di Giosia and Iryna Polishchuk and Eva Weber and Simona Fermani and Andrea Bottoni and Francesco Zerbetto and Boaz Pokroy and Stefania Rapino and Giuseppe Falini and Matteo Calvaresi},
journal= {arXiv preprint arXiv:1609.05462},
year = {2020}
}
备注
Advanced Healthcare Materials, 2015