Related papers: Analytical solution of a generalized Penna model
This paper generalizes a previously published differential equation that describes the relation between the age-specific incidence, remission, and mortality of a disease with its prevalence. The underlying model is a simple compartment…
We present a new model for seed banks, where direct ancestors of individuals may have lived in the near as well as the very far past. The classical Wright-Fisher model, as well as a seed bank model with bounded age distribution considered…
A general model of age-structured population dynamics is developed and the fundamental properties of its solutions are analyzed. The model is a semilinear partial differential equation with a nonlinear nonlocal boundary condition.…
Aging associated brain decline often result in some kind of dementia. Even when this is a complex brain disorder a physical model can be used in order to describe its general behavior. This model is based in first principles. A…
In recent years, there are various methods of estimating Biological Age (BA) have been developed. Especially with the development of machine learning (ML), there are more and more types of BA predictions, and the accuracy has been greatly…
The face is a rich source of information that can be utilized to infer a person's biological age, sex, phenotype, genetic defects, and health status. All of these factors are relevant for predicting an individual's remaining lifespan. In…
We survey the recent mathematical results about aging in certain simple disordered models. We start by the Bouchaud trap model. We then survey the results obtained for simple models of spin-glass dynamics, like the REM (the Random Energy…
My analysis uses methods developed for data mining microarray experiments, adapted for ageing research. Methods bridge knowledge of statistical mechanics with data mining methods developed in statistical mathematics. Analyses can reveal how…
Since its proposition in 1995, the Heumann-Hotzel model has remained as an obscure model of biological aging. The main arguments used against it were its apparent inability to describe populations with many age intervals and its failure to…
No influence was seen when in two models with memory effects the populations were drastically decreased after equilibrium was established, and then allowed to increase again.
In many countries life expectancy gains have been substantially higher than predicted by even recent forecasts. This is primarily due to increasing rates of improvement in old-age mortality not captured by existing models. In this paper we…
Observations of the evolution of species groups in nature, such as well recognized Galapagos finches, have motivated much theoretical research aimed at understanding the processes associated with such radiations. The Penna model is one such…
Aging is a fundamental aspect of living systems that undergo a progressive deterioration of physiological function with age and an increase of vulnerability to disease and death. Living systems, known as complex systems, require complexity…
System dynamics and agent based simulation models can both be used to model and understand interactions of entities within a population. Our modeling work presented here is concerned with understanding the suitability of the different types…
We study age-structured branching models with reproduction law depending on the remaining lifetime of the parent. The lifespan of an individual is decided at its birth and its remaining lifetime decreases at the unit speed. The models…
We consider probabilistic programming for birth-death models of evolution and introduce a new widely-applicable inference method that combines an extension of the alive particle filter (APF) with automatic Rao-Blackwellization via delayed…
Based on the study of cellular aging using the single-cell model organism of budding yeast and corroborated by other studies, we propose the Emergent Aging Model (EAM). EAM hypothesizes that aging is an emergent property of complex…
Models of many-species ecosystems, such as the Lotka-Volterra and replicator equations, suggest that these systems generically exhibit near-extinction processes, where population sizes go very close to zero for some time before rebounding,…
If in the sexual Penna ageing model conditions are applied leading to complementary bit-strings, then marriages between brothers and sisters, or between close cousins, may lead to more offspring than for unrelated couples.
Trap models have been initially proposed as toy models for dynamical relaxation in extremely simplified rough potential energy landscapes. Their importance has considerably grown recently thanks to the discovery that the trap like aging…