Aging associated brain decline often result in some kind of dementia. Even when this is a complex brain disorder a physical model can be used in order to describe its general behavior. This model is based in first principles. A probabilistic model for the development of dementia is obtained and fitted to some experimental data obtained from the Alzheimer's Disease Neuroimaging Initiative. It is explained how dementia appears as a consequence of aging and why it is irreversible.
@article{arxiv.1410.1025,
title = {A physical model for dementia},
author = {Oscar Sotolongo-Costa and L. M. Gaggero-Sager and J. T. Becker and F. Maestú and O. Sotolongo-Grau},
journal= {arXiv preprint arXiv:1410.1025},
year = {2016}
}