Related papers: Mortality decrease and mathematical limit of longe…
Aging associated brain decline often result in some kind of dementia. Even when this is a complex brain disorder a physical model can be used in order to describe its general behavior. This model is based in first principles. A…
Most contemporary mortality models rely on extrapolating trends or past events. However, population dynamics will be significantly impacted by climate change, notably the influence of temperatures on mortality. In this paper, we introduce a…
In this article, we use the illness-death model to present a mathematical framework for studying the compression of morbidity (COM) hypothesis. It turns out that questions about COM are completely determined by the transition rates in the…
In the aftermath of the COVID-19 pandemic, empirical data have revealed that large-scale health crises not only cause immediate disruptions in mortality dynamics but also have persistent effects that may last for several years. Existing…
The Penna model is a model of evolutionary ageing through mutation accumulation where traditionally time and the age of an organism are treated as discrete variables and an organism's genome by a binary bit string. We reformulate the…
A parameter-dependent model involving nonlinear diffusion for an age-structured population is studied. The parameter measures the intensity of the mortality. A bifurcation approach is used to establish existence of positive equilibrium…
Cardiovascular disease, the leading cause of death globally, is an age-related disease. Understanding the morphological and functional changes of the heart during ageing is a key scientific question, the answer to which will help us define…
This paper analyzes mortality cohort effect of birth year and develops an approach to identify and measure cohort effects in mortality data set. The approach is based on differential geometry and leads to an explicit result which can…
Well protected human and laboratory animal populations with abundant resources are evolutionary unprecedented. Physical approach, which takes advantage of their extensively quantified mortality, establishes that its dominant fraction yields…
In epidemiological studies of air pollution and public health, estimating the health impact of exposure to air pollution may be hindered by the unknown functional form of the exposure-outcome association and by unmeasured confounding…
Aging in kinetics of three different phase transitions, viz., magnetic, binary solid and single component fluid, have been studied via Monte Carlo and molecular dynamics simulations in three space dimensions with the objective of…
We combine the Penna Model for biological aging, which is based on the mutation-accumulation theory, with a sort of antagonistic pleiotropy. We show that depending on how the pleiotropy is introduced, it is possible to reproduce both the…
Cellular senescence is thought to play a major role in age-related diseases, which cause nearly 67% of all human deaths worldwide. Recent research in mice showed that exercising mice had higher levels of telomerase, an enzyme that helps…
We use a combination of extreme value theory, survival analysis and computer-intensive methods to analyze the mortality of Italian and French semi-supercentenarians for whom there are validated records. After accounting for the effects of…
In this paper, we suggest a novel method for detecting mortality deceleration. We focus on the gamma-Gompertz frailty model and suggest the subtraction of a penalty in the log-likelihood function as an alternative to traditional likelihood…
The mortality rate of many complex multicellular organisms increase with age, which suggests that net aging damage is accumulative, despite remodeling processes. But how exactly do little mishaps in the cellular level accumulate and spread…
Smoking is one of the main risk factors that has affected human mortality and life expectancy over the past century. Smoking accounts for a large part of the nonlinearities in the growth of life expectancy and of the geographic and sex…
The last two centuries have seen a significant increase in life expectancy. Although past trends suggest that mortality will continue to decline in the future, uncertainty and instability about the development is greatly increased due to…
A new stochastic method for describing mortality is proposed and explored. It is based on differences of observed times series of the transform $\log(-\log x)$ of survival probabilities which seem to follow simple patterns over the years.…
In order to implement disease-specific interventions in young age groups, policy makers in low- and middle-income countries require timely and accurate estimates of age- and cause-specific child mortality. High quality data is not available…