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We present a new approach to the simulation and analysis of immune system behavior. The simulations that can be done with our software package called SIMMUNE are based on immunological data that describe the behavior of immune system agents…

Multiagent Systems · Computer Science 2007-05-23 M. Meier-Schellersheim , G. Mack

The similarity between neural and immune networks has been known for decades, but so far we did not understand the mechanism that allows the immune system, unlike associative neural networks, to recall and execute a large number of…

Disordered Systems and Neural Networks · Physics 2017-03-20 Elena Agliari , Alessia Annibale , Adriano Barra , A. C. C. Coolen , Daniele Tantari

The Dendritic Cell algorithm (DCA) is inspired by recent work in innate immunity. In this paper a formal description of the DCA is given. The DCA is described in detail, and its use as an anomaly detector is illustrated within the context…

Artificial Intelligence · Computer Science 2010-07-05 Julie Greensmith , Uwe Aickelin , Jamie Twycross

In the study of the basic properties observed in the immune system and, in a broader view, in biological systems, several concepts have already been mathematically formulated or treated in an analytical perspective, such as degeneracy,…

Other Quantitative Biology · Quantitative Biology 2008-01-16 Paolo Tieri , Gastone C. Castellani , Claudio Franceschi

The human immune system protects the human body against various pathogens like e.g. biological viruses and bacteria. Artificial immune systems reuse the architecture, organization, and workflows of the human immune system for various…

Multiagent Systems · Computer Science 2008-05-14 Michael Hilker

In a previous paper the authors argued the case for incorporating ideas from innate immunity into artificial immune systems (AISs) and presented an outline for a conceptual framework for such systems. A number of key general properties…

Artificial Intelligence · Computer Science 2010-07-05 Jamie Twycross , Uwe Aickelin

We present ideas about creating a next generation Intrusion Detection System based on the latest immunological theories. The central challenge with computer security is determining the difference between normal and potentially harmful…

Neural and Evolutionary Computing · Computer Science 2010-07-05 Uwe Aickelin , Peter Bentley , Steve Cayzer , Kim Jungwon , Julie McLeod

The adaptive immune system is a natural diagnostic and therapeutic. It recognizes threats earlier than clinical symptoms manifest and neutralizes antigen with exquisite specificity. Recognition specificity and broad reactivity is enabled…

Quantitative Methods · Quantitative Biology 2019-07-26 Alex J. Brown , Igor Snapkov , Rahmad Akbar , Milena Pavlović , Enkelejda Miho , Geir K. Sandve , Victor Greiff

The adaptive immune system is a dynamical, self-organized multiscale system that protects vertebrates from both pathogens and internal irregularities, such as tumours. For these reason it fascinates physicists, yet the multitude of…

Quantitative Methods · Quantitative Biology 2020-11-20 Grégoire Altan-Bonnet , Thierry Mora , Aleksandra M. Walczak

This paper deals with a new model for clonal network dynamics. We describe in detail this model and derive special equations governing immune system dynamics based on the general gradient type principles that can be inherent to a wide class…

Quantitative Methods · Quantitative Biology 2007-05-23 V. V. Gafiychuk , A. K. Prykarpatsky

Organisms have evolved immune systems that can counter pathogenic threats. The adaptive immune system in vertebrates consists of a diverse repertoire of immune receptors that can dynamically reorganize to specifically target the…

Populations and Evolution · Quantitative Biology 2024-10-29 Quinn N Bellamy , Zachary Montague , Luca Peliti , Armita Nourmohammad

An immune system inspired Artificial Immune System (AIS) algorithm is presented, and is used for the purposes of automated program verification. Relevant immunological concepts are discussed and the field of AIS is briefly reviewed. It is…

Neural and Evolutionary Computing · Computer Science 2009-05-19 Soumya Banerjee

Biological systems, unlike physical or chemical systems, are characterized by the very inhomogeneous distribution of their components. The immune system, in particular, is notable for self-organizing its structure. Classically, the dynamics…

Statistical Mechanics · Physics 2007-05-23 Yoram Louzoun , Sorin Solomon , Henri Atlan , Irun R. Cohen

Effective utilization of Multiple-Instruction-Multiple-Data (MIMD) parallel computers requires the application of good load balancing techniques. In this paper we show that heuristics derived from observation of complex natural systems,…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-10-05 James J. Clark

A model of an organism as an autonomous intelligent system has been proposed. This model was used to analyze learning of an organism in various environmental conditions. Processes of learning were divided into two types: strong and weak…

Artificial Intelligence · Computer Science 2007-05-23 Alexey V. Melkikh

We numerically study a dynamical system model of an idiotypic immune network with a small number of degrees of freedom. The model was originally introduced by Varela et.al., and describes antibodies interacting in a body in order to prepare…

Chaotic Dynamics · Physics 2009-10-31 Satoko Itaya , Tatsuya Uezu

Biologically-inspired methods such as evolutionary algorithms and neural networks are proving useful in the field of information fusion. Artificial Immune Systems (AISs) are a biologically-inspired approach which take inspiration from the…

Artificial Intelligence · Computer Science 2010-07-05 Jamie Twycross , Uwe Aickelin

We model the immune surveillance of a pathogen which passes through $n$ immunologically distinct stages. The biological parameters of this system induce a partial order on the stages, and this, in turn, determines which stages will be…

Populations and Evolution · Quantitative Biology 2010-05-04 Edgar Delgado-Eckert , Michael Shapiro

APIs are essential ingredients for developing complex software systems. However, they are difficult to learn and to use. Thus, developers may misuse them, which results in various types of issues. In this paper, we explore the use of a…

Software Engineering · Computer Science 2020-12-29 Maxime Gallais-Jimenez , Hoan A. Nguyen , Mohamed Aymen Saied , Tien N. Nguyen , Houari Sahraoui

A number of works in the field of intrusion detection have been based on Artificial Immune System and Soft Computing. Artificial Immune System based approaches attempt to leverage the adaptability, error tolerance, self- monitoring and…

Cryptography and Security · Computer Science 2012-05-22 Sugata Sanyal , Manoj Rameshchandra Thakur