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Recent advances in operating and manipulating DNA have provided unique experimental possibilities in many fields of DNA research, especially in gene therapy. Researchers have deployed many techniques, experimental and theoretical, to study…

Soft Condensed Matter · Physics 2023-01-04 Arghya Maity , Neha Mathur , Petra Imhof , Navin Singh

We consider multi-chain protein native structures and propose a criterion that determines whether two chains in the system are entangled or not. The criterion is based on the behavior observed by pulling at both temini of each chain…

Biomolecules · Quantitative Biology 2017-07-19 Yani Zhao , Mateusz Chwastyk , Marek Cieplak

In many organisms, homologous (or repetitive) chromosomal regions can associate or/and undergo concerted epigenetic changes in the absence of DNA breakage and recombination. The direct specific pairing of DNA duplexes with similar…

Biomolecules · Quantitative Biology 2022-10-26 Alexey K. Mazur , Eugene Gladyshev

The Kronig-Penney model is used to Study the effect of nonlinear interaction on the transmissive properties of both ordered and disordered chains. In the ordered case, the nonlinearity can either localize or delocalize the electronic states…

Disordered Systems and Neural Networks · Physics 2009-09-25 K. Senouci , N. Zekri , H. Bahlouli , A. K. Sen

Owing to its longevity and enormous information density, DNA, the molecule encoding biological information, has emerged as a promising archival storage medium. However, due to technological constraints, data can only be written onto many…

Emerging Technologies · Computer Science 2018-03-12 Reinhard Heckel , Gediminas Mikutis , Robert N. Grass

The denaturation dynamics of a long double-stranded DNA is studied by means of a model of the Poland-Scheraga type. We note that the linking of the two strands is a locally conserved quantity, hence we introduce local updates that respect…

Statistical Mechanics · Physics 2009-01-28 Marco Baiesi , Roberto Livi

The dynamics of the DNA denaturation is studied using the Peyrard-Bishop-Dauxois model. The denaturation rate of double stranded polymers decreases exponentially as function of length below the denaturation temperature. Above Tc, the rate…

Biological Physics · Physics 2015-06-04 Titus S. van Erp , Michel Peyrard

The translocation of structured RNA or DNA molecules through narrow pores necessitates the opening of all base pairs. Here, we study the interplay between the dynamics of translocation and base-pairing theoretically, using kinetic Monte…

Biomolecules · Quantitative Biology 2009-11-11 Ralf Bundschuh , Ulrich Gerland

We suggest to discriminate single DNA bases via transverse ionic transport, namely by detecting the ionic current that flows in a channel while a single-stranded DNA is driven through an intersecting nanochannel. Our all-atom molecular…

Biological Physics · Physics 2015-06-16 James Wilson , M. Di Ventra

We analyze the ground state localization properties of an array of identical interacting spinless fermionic chains with quasi-random disorder, using non-perturbative Renormalization Group methods. In the single or two chains case…

Disordered Systems and Neural Networks · Physics 2017-03-08 Vieri Mastropietro

We analyze dephasing in a model system where electrons tunnel sequentially through a symmetric interference setup consisting of two single-level quantum dots. Depending on the phase difference between the two tunneling paths, this may…

Mesoscale and Nanoscale Physics · Physics 2007-05-23 Florian Marquardt , C. Bruder

Using Brownian dynamics simulations, we study the migration of long charged chains in an electrophoretic microchannel device consisting of an array of microscopic entropic traps with alternating deep regions and narrow constrictions. Such a…

Biological Physics · Physics 2007-05-23 Martin Streek , Friederike Schmid , Thanh Tu Duong , Alexandra Ros

As a secondary structure of DNA, DNA tetrahedra exhibit intriguing charge transport phenomena and provide a promising platform for wide applications like biosensors, as shown in recent electrochemical experiments. Here, we study charge…

Mesoscale and Nanoscale Physics · Physics 2022-08-30 Pei-Jia Hu , Si-Xian Wang , Xiao-Feng Chen , Xiao-Hui Gao , Tie-Feng Fang , Ai-Min Guo , Qing-Feng Sun

The formation of polaron and its migration in a DNA chain are studied within a semiclassical Peyrard-Biship-Holstein polaron model. Comparing the energetics of the polaron system found from the quantum chemical and semiclassical…

Soft Condensed Matter · Physics 2007-09-10 Dr Julia A. Berashevich , Vadim Apalkov , Tapash Chakraborty

Cooperativity plays an important role in the action of proteins bound to DNA. A simple, mechanical mechanism for cooperativity, in the form of a tension-mediated interaction between proteins bound to DNA at two different locations is…

Soft Condensed Matter · Physics 2009-10-31 Joseph Rudnick , Robijn Bruinsma

Double stranded DNA chain is known to have nontrivial elasticity. We study the effect of this elasticity on the denaturation profile of DNA oligomer by constraining one base pair at one end of the oligomer to remain in unstretched (or…

Soft Condensed Matter · Physics 2007-05-23 Navin Singh , Yashwant Singh

Key properties of a physical system depend on whether it is gapped, i.e. whether its spectral gap has a positive lower bound that is independent of system size. In quantum information theory, the question of whether a system is gapped has…

Quantum Physics · Physics 2021-11-19 Ari Mizel , Van Molino

The ability of double-stranded DNA or RNA to locally melt and form kinks leads to strong non-linear elasticity effects that qualitatively affect their packing in confined spaces. Using analytical theory and numerical simulation we show that…

Soft Condensed Matter · Physics 2024-10-14 James Farrell , Jure Dobnikar , Rudolf Podgornik , Tine Curk

Electron transport through a quantum dot chain with two neighboring dots coupled to both leads is theoretically studied. In such a system, it is found that only for the even-numbered quantum dot structure with the same-number quantum dots…

Mesoscale and Nanoscale Physics · Physics 2008-10-31 Yu Han , Weijiang Gong , Guozhu Wei

We live in a period where bio-informatics is rapidly expanding, a significant quantity of genomic data has been produced as a result of the advancement of high-throughput genome sequencing technology, raising concerns about the costs…

Quantitative Methods · Quantitative Biology 2023-03-10 Mehedi Hasan Sarkar , Adnan Ferdous Ashrafi