Coupled dynamics of RNA folding and nanopore translocation
Biomolecules
2009-11-11 v2 Soft Condensed Matter
Abstract
The translocation of structured RNA or DNA molecules through narrow pores necessitates the opening of all base pairs. Here, we study the interplay between the dynamics of translocation and base-pairing theoretically, using kinetic Monte Carlo simulations and analytical methods. We find that the transient formation of basepairs that do not occur in the ground state can significantly speed up translocation.
Cite
@article{arxiv.q-bio/0508004,
title = {Coupled dynamics of RNA folding and nanopore translocation},
author = {Ralf Bundschuh and Ulrich Gerland},
journal= {arXiv preprint arXiv:q-bio/0508004},
year = {2009}
}
Comments
4 pages, 3 figures, to appear in Physical Review Letters