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We propose RareGraph-Synth, a knowledge-guided, continuous-time diffusion framework that generates realistic yet privacy-preserving synthetic electronic-health-record (EHR) trajectories for ultra-rare diseases. RareGraph-Synth unifies five…

Machine Learning · Computer Science 2025-10-09 Khartik Uppalapati , Shakeel Abdulkareem , Bora Yimenicioglu

The paper utilizes the graph embeddings generated for entities of a large biomedical database to perform link prediction to capture various new relationships among different entities. A novel node similarity measure is proposed that…

Information Retrieval · Computer Science 2021-11-01 Prakhar Gurawa , Matthias Nickles

Sequential recommendation is an extensively explored approach to capturing users' evolving preferences based on past interactions, aimed at predicting their next likely choice. Despite significant advancements in this domain, including…

Information Retrieval · Computer Science 2025-04-15 Kowei Shih , Yi Han , Li Tan

While rich medical datasets are hosted in hospitals distributed across the world, concerns on patients' privacy is a barrier against using such data to train deep neural networks (DNNs) for medical diagnostics. We propose Dopamine, a system…

Machine Learning · Computer Science 2021-02-01 Mohammad Malekzadeh , Burak Hasircioglu , Nitish Mital , Kunal Katarya , Mehmet Emre Ozfatura , Deniz Gündüz

Clinical evidence encompasses the associations and impacts between patients, interventions (such as drugs or physiotherapy), problems, and outcomes. The goal of recommending clinical evidence is to provide medical practitioners with…

Computation and Language · Computer Science 2023-04-05 Maolin Luo , Xiang Zhang

Background: Discovering potential drug-drug interactions (DDIs) is a long-standing challenge in clinical treatments and drug developments. Recently, deep learning techniques have been developed for DDI prediction. However, they generally…

Machine Learning · Computer Science 2024-03-20 Yaqing Wang , Zaifei Yang , Quanming Yao

Background: Drug-drug interactions (DDIs) refer to processes triggered by the administration of two or more drugs leading to side effects beyond those observed when drugs are administered by themselves. Due to the massive number of possible…

Quantitative Methods · Quantitative Biology 2020-12-25 Kyriakos Schwarz , Ahmed Allam , Nicolas Andres Perez Gonzalez , Michael Krauthammer

Clinical diagnosis, which aims to assign diagnosis codes for a patient based on the clinical note, plays an essential role in clinical decision-making. Considering that manual diagnosis could be error-prone and time-consuming, many…

Computation and Language · Computer Science 2021-01-28 Yichao Du , Pengfei Luo , Xudong Hong , Tong Xu , Zhe Zhang , Chao Ren , Yi Zheng , Enhong Chen

Survival analysis or time-to-event analysis aims to model and predict the time it takes for an event of interest to happen in a population or an individual. In the medical context this event might be the time of dying, metastasis,…

Machine Learning · Computer Science 2022-02-09 Shadi Rahimian , Raouf Kerkouche , Ina Kurth , Mario Fritz

Medication recommendations have become an important task in the healthcare domain, especially in measuring the accuracy and safety of medical dialogue systems (MDS). Different from the recommendation task based on electronic health records…

Computation and Language · Computer Science 2025-05-20 Jialun Zhong , Yanzeng Li , Sen Hu , Yang Zhang , Teng Xu , Lei Zou

Precision medicine tailored to individual patients has gained significant attention in recent times. Machine learning techniques are now employed to process personalized data from various sources, including images, genetics, and…

Machine Learning · Computer Science 2023-11-27 Jie Lian , Xufang Luo , Caihua Shan , Dongqi Han , Varut Vardhanabhuti , Dongsheng Li

Sequential recommendation aims at understanding user preference by capturing successive behavior correlations, which are usually represented as the item purchasing sequences based on their past interactions. Existing efforts generally…

Information Retrieval · Computer Science 2024-01-23 Yifang Qin , Wei Ju , Hongjun Wu , Xiao Luo , Ming Zhang

Graph neural networks (GNNs) have demonstrated success in learning representations of brain graphs derived from functional magnetic resonance imaging (fMRI) data. However, existing GNN methods assume brain graphs are static over time and…

Machine Learning · Computer Science 2023-07-11 Alexander Campbell , Antonio Giuliano Zippo , Luca Passamonti , Nicola Toschi , Pietro Lio

Predicting drug side-effects before they occur is a key task in keeping the number of drug-related hospitalizations low and to improve drug discovery processes. Automatic predictors of side-effects generally are not able to process the…

Machine Learning · Statistics 2022-12-01 Pietro Bongini , Elisa Messori , Niccolò Pancino , Monica Bianchini

Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent neurodevelopmental disorder whose neuroimaging-based diagnosis remains challenging due to complex time-varying disruptions in brain connectivity. Functional MRI (fMRI) provides…

Machine Learning · Computer Science 2026-03-30 Qurat Ul Ain , Alptekin Temizel , Soyiba Jawed

Graph augmentation with contrastive learning has gained significant attention in the field of recommendation systems due to its ability to learn expressive user representations, even when labeled data is limited. However, directly applying…

Machine Learning · Computer Science 2024-03-26 Qianru Zhang , Lianghao Xia , Xuheng Cai , Siuming Yiu , Chao Huang , Christian S. Jensen

With the explosive growth of new graduates with research degrees every year, unprecedented challenges arise for early-career researchers to find a job at a suitable institution. This study aims to understand the behavior of academic job…

Social and Information Networks · Computer Science 2022-02-17 Xiangtai Chen , Tao Tang , Jing Ren , Ivan Lee , Honglong Chen , Feng Xia

Laboratory testing and medication prescription are two of the most important routines in daily clinical practice. Developing an artificial intelligence system that can automatically make lab test imputations and medication recommendations…

Machine Learning · Computer Science 2022-02-07 Chengsheng Mao , Liang Yao , Yuan Luo

Deep learning has brought significant progress to medical image classification, yet most existing methods still rely on isolated visual evidence and cannot effectively leverage similar cases or external knowledge. In clinical practice,…

Computer Vision and Pattern Recognition · Computer Science 2026-05-28 Yiming Xu , Yixuan Liu , Yuhang Zhang , Ling Zheng , Yihan Wang , Qi Song

Clinicians prescribe antibiotics by looking at the patient's health record with an experienced eye. However, the therapy might be rendered futile if the patient has drug resistance. Determining drug resistance requires time-consuming…

Artificial Intelligence · Computer Science 2023-03-09 Honglin Shu , Pei Gao , Lingwei Zhu , Zheng Chen
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