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Since its inception, artificial intelligence has relied upon a theoretical foundation centered around perfect rationality as the desired property of intelligent systems. We argue, as others have done, that this foundation is inadequate…
Artificial intelligence (AI) holds great promise for supporting clinical trials, from patient recruitment and endpoint assessment to treatment response prediction. However, deploying AI without safeguards poses significant risks,…
As autonomous agents powered by large language models (LLMs) proliferate in high-stakes domains -- from pharmaceuticals to legal workflows -- the challenge is no longer just intelligence, but verifiability. We introduce TrustTrack, a…
As artificial intelligence (AI) systems increasingly impact society, the EU Artificial Intelligence Act (AIA) is the first serious legislative attempt to contain the harmful effects of AI systems. This paper proposes a governance framework…
The human immune system has numerous properties that make it ripe for exploitation in the computational domain, such as robustness and fault tolerance, and many different algorithms, collectively termed Artificial Immune Systems (AIS), have…
Rapid advances in Generative AI are giving rise to increasingly sophisticated Multi-Agent AI (MAAI) systems. While AI fairness has been extensively studied in traditional predictive scenarios, its examination in MAAI remains nascent and…
As AI regulations around the world intensify their focus on system safety, contestability has become a mandatory, yet ill-defined, safeguard. In XAI, "contestability" remains an empty promise: no formal definition exists, no algorithm…
Estimating the governing equation parameter values is essential for integrating experimental data with scientific theory to understand, validate, and predict the dynamics of complex systems. In this work, we propose a new method for…
While current deep learning systems excel at tasks such as object classification, language processing, and gameplay, few can construct or modify a complex system such as a tower of blocks. We hypothesize that what these systems lack is a…
Artificial intelligence is often measured by the range of tasks it can perform. Yet wide ability without depth remains only an imitation. This paper proposes a Structural-Generative Ontology of Intelligence: true intelligence exists only…
Generative modeling has become a central paradigm in protein research, extending machine learning beyond structure prediction toward sequence design, backbone generation, inverse folding, and biomolecular interaction modeling. However, the…
Trust management provides an alternative solution for securing open, dynamic, and distributed multi-agent systems, where conventional cryptographic methods prove to be impractical. However, existing trust models face challenges related to…
The implementation of agentic AI systems has the potential of providing more helpful AI systems in a variety of applications. These systems work autonomously towards a defined goal with reduced external control. Despite their potential, one…
Modern agentic frameworks (e.g., CrewAI and AutoGen) have evolved into complex, autonomous multi-agent systems, introducing unique reliability challenges beyond earlier pipeline-based LLM libraries. However, existing empirical studies focus…
Frontier AI systems require governance mechanisms that can verify internal alignment, not just behavioral compliance. Private governance mechanisms audits, certification, insurance, and procurement are emerging to complement public…
Ever since the creation of the first artificial intelligence (AI) machinery built on machine learning (ML), public society has entertained the idea that eventually computers could become sentient and develop a consciousness of their own. As…
Agent-based modeling (ABM) is a powerful computational approach for studying complex biological and biomedical systems, yet its widespread use remains limited by significant computational demands. As models become increasingly…
Long-lived AI agents are increasingly deployed as persistent operational systems, yet they are still evaluated like freshly initialized models. Day-one benchmarks miss a basic systems question: how long does an agent remain reliable after…
Evaluating AI agents on comprehensive benchmarks is expensive because each evaluation requires interactive rollouts with tool use and multi-step reasoning. We study whether small task subsets can preserve agent rankings at substantially…
Artificial Intelligence frameworks should allow for ever more autonomous and general systems in contrast to very narrow and restricted (human pre-defined) domain systems, in analogy to how the brain works. Self-constructive Artificial…