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Background: Identification of the interactions and regulatory relations between biomolecules play pivotal roles in understanding complex biological systems and the mechanisms underlying diverse biological functions. However, the collection…

Computation and Language · Computer Science 2025-04-24 Gilchan Park , Byung-Jun Yoon , Xihaier Luo , Vanessa López-Marrero , Shinjae Yoo , Shantenu Jha

Data science plays a critical role in biomedical research, but it requires professionals with expertise in coding and medical data analysis. Large language models (LLMs) have shown great potential in supporting medical tasks and performing…

Artificial Intelligence · Computer Science 2025-04-10 Zifeng Wang , Benjamin Danek , Ziwei Yang , Zheng Chen , Jimeng Sun

Large language models (LLMs) are emerging as valuable tools to support clinicians in routine decision-making. HIV management is a compelling use case due to its complexity, including diverse treatment options, comorbidities, and adherence…

Computation and Language · Computer Science 2025-07-28 Gonzalo Cardenal-Antolin , Jacques Fellay , Bashkim Jaha , Roger Kouyos , Niko Beerenwinkel , Diane Duroux

Large language models (LLMs) have demonstrated remarkable proficiency in mainstream academic disciplines such as mathematics, physics, and computer science. However, human knowledge encompasses over 200 specialized disciplines, far…

The advent of large language models (LLMs) has unlocked great opportunities in complex data management tasks, particularly in question answering (QA) over complicated multi-table relational data. Despite significant progress, systematically…

Artificial Intelligence · Computer Science 2024-12-02 Zipeng Qiu , You Peng , Guangxin He , Binhang Yuan , Chen Wang

Large language models (LLMs) are powerful tools capable of handling diverse tasks. Comparing and selecting appropriate LLMs for specific tasks requires systematic evaluation methods, as models exhibit varying capabilities across different…

Computation and Language · Computer Science 2025-06-04 Anna Sokol , Elizabeth Daly , Michael Hind , David Piorkowski , Xiangliang Zhang , Nuno Moniz , Nitesh Chawla

As Large Language Models (LLMs) advance, their potential for widespread societal impact grows simultaneously. Hence, rigorous LLM evaluations are both a technical necessity and social imperative. While numerous evaluation benchmarks have…

Computation and Language · Computer Science 2025-04-22 Jaime Raldua Veuthey , Zainab Ali Majid , Suhas Hariharan , Jacob Haimes

Large language models (LLMs) are increasingly evaluated on their ability to perform multi-hop reasoning, i.e., to combine multiple pieces of information into a coherent inference. We introduce KinshipQA, a benchmark designed to probe this…

Computation and Language · Computer Science 2026-01-13 Tianda Sun , Dimitar Kazakov

High-content perturbation experiments allow scientists to probe biomolecular systems at unprecedented resolution, but experimental and analysis costs pose significant barriers to widespread adoption. Machine learning has the potential to…

Artificial Intelligence · Computer Science 2025-03-03 Menghua Wu , Russell Littman , Jacob Levine , Lin Qiu , Tommaso Biancalani , David Richmond , Jan-Christian Huetter

Large Language Models (LLMs) have the potential of facilitating the development of Artificial Intelligence technology to assist medical experts for interactive decision support, which has been demonstrated by their competitive performances…

Computation and Language · Computer Science 2024-11-12 Iñigo Alonso , Maite Oronoz , Rodrigo Agerri

Interpreting transcriptomic data is one of the most common analytical tasks in modern biology. Yet most current models either consume expression profiles without producing natural-language biological explanations, or reason in language…

The intricate relationship between genetic variation and human diseases has been a focal point of medical research, evidenced by the identification of risk genes regarding specific diseases. The advent of advanced genome sequencing…

Quantitative Methods · Quantitative Biology 2024-01-19 Jiayu Chang , Shiyu Wang , Chen Ling , Zhaohui Qin , Liang Zhao

Most large language models (LLMs) are trained once and never updated; thus, they lack the ability to dynamically adapt to our ever-changing world. In this work, we perform a detailed study of the factuality of LLM-generated text in the…

Computation and Language · Computer Science 2023-11-23 Tu Vu , Mohit Iyyer , Xuezhi Wang , Noah Constant , Jerry Wei , Jason Wei , Chris Tar , Yun-Hsuan Sung , Denny Zhou , Quoc Le , Thang Luong

Predicting enzymatic reactions is crucial for applications in biocatalysis, metabolic engineering, and drug discovery, yet it remains a complex and resource-intensive task. Large Language Models (LLMs) have recently demonstrated remarkable…

Artificial Intelligence · Computer Science 2025-05-12 Lorenzo Di Fruscia , Jana Marie Weber

There are already many DNA large language models, but most of them still follow traditional uses, such as extracting sequence features for classification tasks. More innovative applications of large language models, such as prompt…

Genomics · Quantitative Biology 2024-10-29 Wang Liang

The recent success of Large Language Models (LLM) in a wide range of Natural Language Processing applications opens the path towards novel Question Answering Systems over Knowledge Graphs leveraging LLMs. However, one of the main obstacles…

Artificial Intelligence · Computer Science 2025-08-26 Julio C. Rangel , Tarcisio Mendes de Farias , Ana Claudia Sima , Norio Kobayashi

We present TuringQ, the first benchmark designed to evaluate the reasoning capabilities of large language models (LLMs) in the theory of computation. TuringQ consists of 4,006 undergraduate and graduate-level question-answer pairs,…

Computation and Language · Computer Science 2024-10-10 Pardis Sadat Zahraei , Ehsaneddin Asgari

The integration of artificial intelligence into various domains is rapidly increasing, with Large Language Models (LLMs) becoming more prevalent in numerous applications. This work is included in an overall project which aims to train an…

Computational Physics · Physics 2025-01-09 Christophe Bajan , Guillaume Lambard

While large language models now handle million-token contexts, their capacity for reasoning across entire document repositories remains largely untested. Existing benchmarks are inadequate, as they are mostly limited to single long texts or…

Computation and Language · Computer Science 2026-04-28 Zhiyuan Lu , Chenliang Li , Yingcheng Shi , Weizhou Shen , Ming Yan , Fei Huang

Large Language Model (LLM) has gained popularity and achieved remarkable results in open-domain tasks, but its performance in real industrial domain-specific scenarios is average due to its lack of specific domain knowledge. This issue has…

Computation and Language · Computer Science 2023-10-17 Fangkai Yang , Pu Zhao , Zezhong Wang , Lu Wang , Jue Zhang , Mohit Garg , Qingwei Lin , Saravan Rajmohan , Dongmei Zhang