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In contrast to their remarkable performance on general knowledge QA, the true abilities of Large Language Models (LLMs) in tasks demanding deep, specialized reasoning, such as in protein biology, have yet to be thoroughly investigated.…

Quantitative Methods · Quantitative Biology 2025-12-30 Dingyi Rong , Zijian Chen , Qi Jia , Kaiwei Zhang , Haotian Lu , Guangtao Zhai , Ning Liu

Purpose: Artificial intelligence (AI), and in particular large language models (LLMs), are increasingly being explored as tools to support life cycle assessment (LCA). While demonstrations exist across environmental and social domains,…

Computation and Language · Computer Science 2025-10-24 Artur Donaldson , Bharathan Balaji , Cajetan Oriekezie , Manish Kumar , Laure Patouillard

Frontier large language models (LLMs), such as GPT-5, Claude 4.5, Gemini 3, Llama 4, and DeepSeek-R1, represent a transformative class of AI tools capable of revolutionizing various aspects of healthcare by generating human-like responses…

Inspired by the success of large language models (LLM) for DNA and proteins, several LLM for RNA have been developed recently. RNA-LLM uses large datasets of RNA sequences to learn, in a self-supervised way, how to represent each RNA base…

Artificial Intelligence · Computer Science 2025-02-04 L. I. Zablocki , L. A. Bugnon , M. Gerard , L. Di Persia , G. Stegmayer , D. H. Milone

Large language models (LLMs) have demonstrated remarkable advancements, primarily due to their capabilities in modeling the hidden relationships within text sequences. This innovation presents a unique opportunity in the field of life…

Genomics · Quantitative Biology 2024-12-25 Cong Li , Qingqing Long , Yuanchun Zhou , Meng Xiao

Recent advances have been improving the context windows of Large Language Models (LLMs). To quantify the real long-context capabilities of LLMs, evaluators such as the popular Needle in a Haystack have been developed to test LLMs over a…

Software Engineering · Computer Science 2024-06-11 Jiawei Liu , Jia Le Tian , Vijay Daita , Yuxiang Wei , Yifeng Ding , Yuhan Katherine Wang , Jun Yang , Lingming Zhang

A graph is a fundamental data model to represent various entities and their complex relationships in society and nature, such as social networks, transportation networks, and financial networks. Recently, large language models (LLMs) have…

Computation and Language · Computer Science 2025-07-08 Wenbo Shang , Xin Huang

Recently, large language models (LLMs) have expanded into various domains. However, there remains a need to evaluate how these models perform when prompted with commonplace queries compared to domain-specific queries, which may be useful…

Computation and Language · Computer Science 2024-08-22 Oluyemi Enoch Amujo , Shanchieh Jay Yang

Large language models (LLMs) process and predict sequences containing text to answer questions, and address tasks including document summarization, providing recommendations, writing software and solving quantitative problems. We provide a…

Numerical Analysis · Mathematics 2026-02-02 Ricardo Baptista , Andrew Stuart , Son Tran

The modeling of bio-molecular system across molecular scales remains a central challenge in scientific research. Large language models (LLMs) are increasingly applied to bio-molecular discovery, yet systematic evaluation across multi-scale…

Machine Learning · Computer Science 2026-04-07 Yaxin Xu , Yue Zhou , Tianyu Zhao , Fengwei An , Zhixiang Ren

Emerging topics in biomedical research are continuously expanding, providing a wealth of information about genes and their function. This rapid proliferation of knowledge presents unprecedented opportunities for scientific discovery and…

Genomics · Quantitative Biology 2024-12-25 Zhijian Chen , Chuan Hu , Min Wu , Qingqing Long , Xuezhi Wang , Yuanchun Zhou , Meng Xiao

Large Language Models (LLMs) have demonstrated significant promise for various applications in healthcare. However, their efficacy in the Arabic medical domain remains unexplored due to the lack of high-quality domain-specific datasets and…

Computation and Language · Computer Science 2025-08-25 Mouath Abu Daoud , Chaimae Abouzahir , Leen Kharouf , Walid Al-Eisawi , Nizar Habash , Farah E. Shamout

Benchmarks establish a standardized evaluation framework to systematically assess the performance of large language models (LLMs), facilitating objective comparisons and driving advancements in the field. However, existing benchmarks fail…

Computation and Language · Computer Science 2026-02-16 Ziqian Zhang , Xingjian Hu , Yue Huang , Kai Zhang , Ruoxi Chen , Yixin Liu , Qingsong Wen , Kaidi Xu , Xiangliang Zhang , Neil Zhenqiang Gong , Lichao Sun

Large audio language models (LALMs) leverage multimodal representations to generate open-ended answers to natural language queries about audio. In this paper, we (1) provide empirical evidence that assessment of LALMs using the popular…

Sound · Computer Science 2026-05-28 Daniel Chenyu Lin , Michael Freeman , John Thickstun

Pre-trained language models (LMs) have become ubiquitous in solving various natural language processing (NLP) tasks. There has been increasing interest in what knowledge these LMs contain and how we can extract that knowledge, treating LMs…

Computation and Language · Computer Science 2021-09-16 Mujeen Sung , Jinhyuk Lee , Sean Yi , Minji Jeon , Sungdong Kim , Jaewoo Kang

In this paper, we introduce and apply Operations Research Question Answering (ORQA), a new benchmark designed to assess the generalization capabilities of Large Language Models (LLMs) in the specialized technical domain of Operations…

Large Language Models (LLMs) have revolutionized the field of Natural Language Processing thanks to their ability to reuse knowledge acquired on massive text corpora on a wide variety of downstream tasks, with minimal (if any) tuning steps.…

Computation and Language · Computer Science 2024-07-12 Flavio Petruzzellis , Alberto Testolin , Alessandro Sperduti

Clinical problem-solving requires processing of semantic medical knowledge such as illness scripts and numerical medical knowledge of diagnostic tests for evidence-based decision-making. As large language models (LLMs) show promising…

Multilingual large language models (LLMs) have minimized the fluency gap between languages. This advancement, however, exposes models to the risk of biased behavior, as knowledge and norms may propagate across languages. In this work, we…

Computation and Language · Computer Science 2026-04-22 Guy Mor-Lan , Omer Goldman , Matan Eyal , Adi Mayrav Gilady , Sivan Eiger , Idan Szpektor , Avinatan Hassidim , Yossi Matias , Reut Tsarfaty

Despite their sophisticated capabilities, large language models (LLMs) encounter a major hurdle in effective assessment. This paper first revisits the prevalent evaluation method-multiple choice question answering (MCQA), which allows for…

Computation and Language · Computer Science 2024-03-13 Fangyun Wei , Xi Chen , Lin Luo
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