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Gene/protein interactions provide critical information for a thorough understanding of cellular processes. Recently, considerable interest and effort has been focused on the construction and analysis of genome-wide gene networks. The large…

Molecular Networks · Quantitative Biology 2022-04-25 Xin Li , Hsinchun Chen , Zan Huang , Hua Su , Jesse D. Martinez

Large language models (LLMs) often struggle with knowledge-intensive tasks due to a lack of background knowledge and a tendency to hallucinate. To address these limitations, integrating knowledge graphs (KGs) with LLMs has been intensively…

Computation and Language · Computer Science 2025-06-13 Yilin Xiao , Chuang Zhou , Qinggang Zhang , Bo Li , Qing Li , Xiao Huang

Graph-based retrieval-augmented generation (RAG) enriches large language models (LLMs) with external knowledge for long-context understanding and multi-hop reasoning, but existing methods face a granularity dilemma: fine-grained…

Computation and Language · Computer Science 2025-09-26 Yaxiong Wu , Jianyuan Bo , Yongyue Zhang , Sheng Liang , Yong Liu

Retrieval-Augmented Generation (RAG) has demonstrated significant effectiveness in enhancing large language models (LLMs) for complex multi-hop question answering (QA). For multi-hop QA tasks, current iterative approaches predominantly rely…

Computation and Language · Computer Science 2026-01-19 Yuling Shi , Maolin Sun , Zijun Liu , Mo Yang , Yixiong Fang , Tianran Sun , Xiaodong Gu

Motivation: Biomedical knowledge graphs (KGs) are crucial for drug discovery and disease understanding, yet their completion and reasoning are challenging. Knowledge Embedding (KE) methods capture global semantics but struggle with dynamic…

Artificial Intelligence · Computer Science 2025-07-23 Yitong Lin , Jiaying He , Jiahe Chen , Xinnan Zhu , Jianwei Zheng , Tao Bo

This study aims to optimize the existing retrieval-augmented generation model (RAG) by introducing a graph structure to improve the performance of the model in dealing with complex knowledge reasoning tasks. The traditional RAG model has…

Information Retrieval · Computer Science 2024-11-07 Yuxin Dong , Shuo Wang , Hongye Zheng , Jiajing Chen , Zhenhong Zhang , Chihang Wang

Large language models (LLMs) have recently become the leading source of answers for users' questions online. Despite their ability to offer eloquent answers, their accuracy and reliability can pose a significant challenge. This is…

Computation and Language · Computer Science 2024-07-09 Bojana Bašaragin , Adela Ljajić , Darija Medvecki , Lorenzo Cassano , Miloš Košprdić , Nikola Milošević

Radiology Report Generation (RRG) through Vision-Language Models (VLMs) promises to reduce documentation burden, improve reporting consistency, and accelerate clinical workflows. However, their clinical adoption remains limited by the lack…

Computer Vision and Pattern Recognition · Computer Science 2026-02-18 Marco Salmè , Federico Siciliano , Fabrizio Silvestri , Paolo Soda , Rosa Sicilia , Valerio Guarrasi

Large language models (LLMs) offer new opportunities for constructing knowledge graphs (KGs) from unstructured clinical narratives. However, existing approaches often rely on structured inputs and lack robust validation of factual accuracy…

Artificial Intelligence · Computer Science 2026-01-06 Udiptaman Das , Krishnasai B. Atmakuri , Duy Ho , Chi Lee , Yugyung Lee

Genetic interaction measures how different genes collectively contribute to a phenotype, and can reveal functional compensation and buffering between pathways under genetic perturbations. Recently, genome-wide screening for genetic…

Molecular Networks · Quantitative Biology 2015-03-17 Gang Fang , Wen Wang , Vanja Paunic , Benjamin Oately , Majda Haznadar , Michael Steinbach , Brian Van Ness , Chad L. Myers , Vipin Kumar

In this paper, we present a novel diagnostic framework that integrates Knowledge Graphs (KGs) and Large Language Models (LLMs) to support system diagnostics in high-reliability systems such as nuclear power plants. Traditional diagnostic…

Artificial Intelligence · Computer Science 2025-09-01 Saman Marandi , Yu-Shu Hu , Mohammad Modarres

Retrieval-augmented generation (RAG) is a key means to effectively enhance large language models (LLMs) in many knowledge-based tasks. However, existing RAG methods struggle with knowledge-intensive reasoning tasks, because useful…

Computation and Language · Computer Science 2024-10-28 Zhuoqun Li , Xuanang Chen , Haiyang Yu , Hongyu Lin , Yaojie Lu , Qiaoyu Tang , Fei Huang , Xianpei Han , Le Sun , Yongbin Li

Retrieval-augmented generation (RAG) has emerged as a promising technology for addressing hallucination issues in the responses generated by large language models (LLMs). Existing studies on RAG primarily focus on applying semantic-based…

Computation and Language · Computer Science 2025-02-12 Xiangrong Zhu , Yuexiang Xie , Yi Liu , Yaliang Li , Wei Hu

Knowledge-graph retrieval-augmented generation (KG-RAG) couples large language models (LLMs) with structured, verifiable knowledge graphs (KGs) to reduce hallucination and provide reasoning traces. However, current KG-RAG systems often rely…

Computation and Language · Computer Science 2026-05-25 Junhong Lin , Shicheng Liu , Jinyeop Song , Song Wang , Julian Shun , Yada Zhu

Polymer literature contains a large and growing body of experimental knowledge, yet much of it is buried in unstructured text and inconsistent terminology, making systematic retrieval and reasoning difficult. Existing tools typically…

Computational Engineering, Finance, and Science · Computer Science 2026-02-19 Sonakshi Gupta , Akhlak Mahmood , Wei Xiong , Rampi Ramprasad

Graph Retrieval-Augmented Generation (GRAG or Graph RAG) architectures aim to enhance language understanding and generation by leveraging external knowledge. However, effectively capturing and integrating the rich semantic information…

Computation and Language · Computer Science 2025-01-29 Karishma Thakrar

Large language models (LLMs) still struggle with multi-hop reasoning over knowledge-graphs (KGs), and we identify a previously overlooked structural reason for this difficulty: Transformer attention heads naturally specialize in distinct…

Computation and Language · Computer Science 2026-04-15 Jinliang Liu , Jiale Bai , Shaoning Zeng

Large Language Models (LLMs) have demonstrated significant potential across various domains. However, they often struggle with integrating external knowledge and performing complex reasoning, leading to hallucinations and unreliable…

Machine Learning · Computer Science 2025-11-25 Yao Cheng , Yibo Zhao , Jiapeng Zhu , Yao Liu , Xing Sun , Xiang Li

Retrieval-Augmented Generation (RAG) systems for biomedical literature are typically evaluated using ranking metrics like Mean Reciprocal Rank (MRR), which measure how well the system identifies the single most relevant chunk. We argue that…

Artificial Intelligence · Computer Science 2026-03-25 Pouria Mortezaagha , Arya Rahgozar

Evidence-based medicine (EBM) plays a crucial role in the application of large language models (LLMs) in healthcare, as it provides reliable support for medical decision-making processes. Although it benefits from current…

Computation and Language · Computer Science 2025-03-24 Chengfeng Dou , Ying Zhang , Zhi Jin , Wenpin Jiao , Haiyan Zhao , Yongqiang Zhao , Zhengwei Tao