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Despite tremendous progress in computer vision, there has not been an attempt for machine learning on very large-scale medical image databases. We present an interleaved text/image deep learning system to extract and mine the semantic…

Computer Vision and Pattern Recognition · Computer Science 2015-05-05 Hoo-Chang Shin , Le Lu , Lauren Kim , Ari Seff , Jianhua Yao , Ronald M. Summers

Although explainability is essential in the clinical diagnosis, most deep learning models still function as black boxes without elucidating their decision-making process. In this study, we investigate the explainable model development that…

Computer Vision and Pattern Recognition · Computer Science 2024-09-20 Yunhe Gao , Difei Gu , Mu Zhou , Dimitris Metaxas

If two experts disagree on a test, we may conclude both cannot be 100 per cent correct. But if they completely agree, no possible evaluation can be excluded. This asymmetry in the utility of agreements versus disagreements is explored here…

Artificial Intelligence · Computer Science 2025-10-02 Andrés Corrada-Emmanuel

Large Language Models (LLMs) are transforming scholarly tasks like search and summarization, but their reliability remains uncertain. Current evaluation metrics for testing LLM reliability are primarily automated approaches that prioritize…

Human-Computer Interaction · Computer Science 2026-02-25 Anna Martin-Boyle , William Humphreys , Martha Brown , Cara Leckey , Harmanpreet Kaur

AI agents that communicate on behalf of individuals need to capture how each person actually communicates, yet current approaches either require costly per-person fine-tuning, produce generic outputs from shallow persona descriptions, or…

Human-Computer Interaction · Computer Science 2026-03-31 Ruoxi Shang , Dan Marshall , Edward Cutrell , Denae Ford

Current benchmarks for AI clinician systems, often based on multiple-choice exams or manual rubrics, fail to capture the depth, robustness, and safety required for real-world clinical practice. To address this, we introduce the GAPS…

The wide exploration of large language models (LLMs) raises the awareness of alignment between healthcare stakeholder preferences and model outputs. This alignment becomes a crucial foundation to empower the healthcare workflow effectively,…

Computers and Society · Computer Science 2025-05-07 Kexin Ding , Mu Zhou , Akshay Chaudhari , Shaoting Zhang , Dimitris N. Metaxas

Recent advancements in vision-language models have achieved remarkable results in making language models understand vision inputs. However, a unified approach to align these models across diverse tasks such as image captioning and visual…

Computer Vision and Pattern Recognition · Computer Science 2025-03-26 Kartik Jangra , Aman Kumar Singh , Yashwani Mann , Geetanjali Rathee

General Alignment has improved average-case helpfulness and safety, but current alignment practice still rewards confident, single-turn responses. The problem is not only that models fail on edge cases; it is that current evaluation makes…

Computation and Language · Computer Science 2026-05-19 Han Bao , Yue Huang , Xiaoda Wang , Zheyuan Zhang , Yujun Zhou , Carl Yang , Xiangliang Zhang , Yanfang Ye

Medical imaging plays a vital role in modern diagnostics; however, interpreting high-resolution radiological data remains time-consuming and susceptible to variability among clinicians. Traditional image processing techniques often lack the…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Melika Filvantorkaman , Maral Filvan Torkaman

The recent boom of large language models (LLMs) has re-ignited the hope that artificial intelligence (AI) systems could aid medical diagnosis. Yet despite dazzling benchmark scores, LLM assistants have yet to deliver measurable improvements…

Artificial Intelligence · Computer Science 2025-07-03 Matthew JY Kang , Wenli Yang , Monica R Roberts , Byeong Ho Kang , Charles B Malpas

Large language models are increasingly being assembled into medical multi-agent systems that emulate multidisciplinary consultation through specialist roles, peer review and consensus formation. In clinical decision support, however,…

Computation and Language · Computer Science 2026-05-28 Yinghao Zhu , Lei Gu , Zixiang Wang , Haoran Sang , Dehao Sui , Wen Tang , Lan Mi , Yasha Wang , Junyi Gao , Liang Yao , Tianfan Fu , Ewen Harrison , Lequan Yu , Liantao Ma

A key step in medical diagnosis is giving the patient a universally recognized label (e.g. Appendicitis) which essentially assigns the patient to a class(es) of patients with similar body failures. However, two patients having the same…

Artificial Intelligence · Computer Science 2019-09-10 Moshe BenBassat

Large language models (LLMs) offer transformative potential for clinical decision support in spine surgery but pose significant risks through hallucinations, which are factually inconsistent or contextually misaligned outputs that may…

Machine Learning · Computer Science 2025-11-21 Dong Chen , Yanzhe Wei , Zonglin He , Guan-Ming Kuang , Canhua Ye , Meiru An , Huili Peng , Yong Hu , Huiren Tao , Kenneth MC Cheung

With the increasing adoption of Artificial Intelligence (AI) systems in high-stake domains, such as healthcare, effective collaboration between domain experts and AI is imperative. To facilitate effective collaboration between domain…

Human-Computer Interaction · Computer Science 2024-05-24 Aditya Bhattacharya , Simone Stumpf , Katrien Verbert

Evaluating AI-generated medical image segmentations for clinical acceptability poses a significant challenge, as traditional pixelagreement metrics often fail to capture true diagnostic utility. This paper introduces Hierarchical Clinical…

Image and Video Processing · Electrical Eng. & Systems 2025-06-03 Jiaxi Sheng , Leyi Yu , Haoyue Li , Yifan Gao , Xin Gao

The increasing deployment of artificial intelligence (AI) in clinical settings challenges foundational assumptions underlying traditional frameworks of medical evidence. Classical statistical approaches, centered on randomized controlled…

Methodology · Statistics 2026-01-07 Richik Chakraborty

This paper primarily demonstrates a method to quantitatively assess the alignment between multi-step, structured reasoning in large language models and human preferences. We introduce the Alignment Score, a semantic-level metric that…

Artificial Intelligence · Computer Science 2026-04-22 Boxuan Wang , Zhuoyun Li , Xinmiao Huang , Xiaowei Huang , Yi Dong

Despite the growing clinical adoption of large language models (LLMs), current approaches heavily rely on single model architectures. To overcome risks of obsolescence and rigid dependence on single model systems, we present a novel…

Artificial Intelligence · Computer Science 2025-06-24 Amit Kumthekar , Zion Tilley , Henry Duong , Bhargav Patel , Michael Magnoli , Ahmed Omar , Ahmed Nasser , Chaitanya Gharpure , Yevgen Reztzov

Commonly, AI or machine learning (ML) models are evaluated on benchmark datasets. This practice supports innovative methodological research, but benchmark performance can be poorly correlated with performance in real-world applications -- a…

Machine Learning · Computer Science 2024-06-18 Olivier Binette , Jerome P. Reiter