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Interpretability is essential in medical imaging to ensure that clinicians can comprehend and trust artificial intelligence models. Several approaches have been recently considered to encode attributes in the latent space to enhance its…

Image and Video Processing · Electrical Eng. & Systems 2024-08-27 Maxime Di Folco , Cosmin I. Bercea , Emily Chan , Julia A. Schnabel

Local explanations of learning-to-rank (LTR) models are thought to extract the most important features that contribute to the ranking predicted by the LTR model for a single data point. Evaluating the accuracy of such explanations is…

Machine Learning · Statistics 2022-03-17 Amir Hossein Akhavan Rahnama , Judith Butepage

Rule-based models, e.g., decision trees, are widely used in scenarios demanding high model interpretability for their transparent inner structures and good model expressivity. However, rule-based models are hard to optimize, especially on…

Machine Learning · Computer Science 2024-01-31 Zhuo Wang , Wei Zhang , Ning Liu , Jianyong Wang

The lack of interpretability remains a barrier to the adoption of deep neural networks. Recently, tree regularization has been proposed to encourage deep neural networks to resemble compact, axis-aligned decision trees without significant…

Machine Learning · Computer Science 2020-03-17 Mike Wu , Sonali Parbhoo , Michael Hughes , Ryan Kindle , Leo Celi , Maurizio Zazzi , Volker Roth , Finale Doshi-Velez

Estimating individualised treatment effect (ITE) -- that is the causal effect of a set of variables (also called exposures, treatments, actions, policies, or interventions), referred to as \textit{composite treatments}, on a set of outcome…

Machine Learning · Computer Science 2025-12-19 Vinod Kumar Chauhan , Lei Clifton , Gaurav Nigam , David A. Clifton

Deep learning methods, in particular convolutional neural networks, have emerged as a powerful tool in medical image computing tasks. While these complex models provide excellent performance, their black-box nature may hinder real-world…

Image and Video Processing · Electrical Eng. & Systems 2022-10-18 Yuzhe Lu , Adam Perer

Many batch RL health applications first discretize time into fixed intervals. However, this discretization both loses resolution and forces a policy computation at each (potentially fine) interval. In this work, we develop a novel framework…

Machine Learning · Computer Science 2021-01-12 Kristine Zhang , Yuanheng Wang , Jianzhun Du , Brian Chu , Leo Anthony Celi , Ryan Kindle , Finale Doshi-Velez

Precision mental health requires treatment decisions that account for heterogeneous symptoms reflecting multiple clinical domains. However, existing methods for estimating individualized treatment effects (ITE) rely on a single summary…

Machine Learning · Computer Science 2026-03-31 Yuying Lu , Wenbo Fei , Yuanjia Wang , Molei Liu

Gradient-based approaches in reinforcement learning (RL) have achieved tremendous success in learning policies for autonomous vehicles. While the performance of these approaches warrants real-world adoption, these policies lack…

Machine Learning · Computer Science 2023-08-01 Rohan Paleja , Yaru Niu , Andrew Silva , Chace Ritchie , Sugju Choi , Matthew Gombolay

Deep reinforcement learning (RL) has recently led to many breakthroughs on a range of complex control tasks. However, the agent's decision-making process is generally not transparent. The lack of interpretability hinders the applicability…

Computer Vision and Pattern Recognition · Computer Science 2021-03-22 Wenjie Shi , Gao Huang , Shiji Song , Zhuoyuan Wang , Tingyu Lin , Cheng Wu

Interpretability and transparency are essential for incorporating causal effect models from observational data into policy decision-making. They can provide trust for the model in the absence of ground truth labels to evaluate the accuracy…

Methodology · Statistics 2024-02-01 Lucile Ter-Minassian , Liran Szlak , Ehud Karavani , Chris Holmes , Yishai Shimoni

An individualized dose rule recommends a dose level within a continuous safe dose range based on patient level information such as physical conditions, genetic factors and medication histories. Traditionally, personalized dose finding…

Methodology · Statistics 2020-07-21 Liangyu Zhu , Wenbin Lu , Michael R. Kosorok , Rui Song

There is a need of ensuring machine learning models that are interpretable. Higher interpretability of the model means easier comprehension and explanation of future predictions for end-users. Further, interpretable machine learning models…

Machine Learning · Computer Science 2020-08-17 Gregor Stiglic , Primoz Kocbek , Nino Fijacko , Marinka Zitnik , Katrien Verbert , Leona Cilar

Dynamic Treatment Regimes (DTRs) provide a systematic framework for optimizing sequential decision-making in chronic disease management, where therapies must adapt to patients' evolving clinical profiles. Inverse probability weighting (IPW)…

Methodology · Statistics 2026-03-26 Chloe Si , David A. Stephens , Erica E. M. Moodie

Building models of human decision-making from observed behaviour is critical to better understand, diagnose and support real-world policies such as clinical care. As established policy learning approaches remain focused on imitation…

Machine Learning · Computer Science 2022-10-03 Alizée Pace , Alex J. Chan , Mihaela van der Schaar

Estimation of individualized treatment effects (ITE) from observational studies is a fundamental problem in causal inference and holds significant importance across domains, including healthcare. However, limited observational datasets pose…

Machine Learning · Computer Science 2024-02-14 Vinod Kumar Chauhan , Jiandong Zhou , Ghadeer Ghosheh , Soheila Molaei , David A. Clifton

In real-world healthcare settings, treatment decisions often involve optimizing for multivariate outcomes such as treatment efficacy and severity of side effects based on individual preferences. However, existing statistical methods for…

Machine Learning · Statistics 2025-09-03 Joshua P. Zitovsky , Yating Zou , Leslie Wilson , Michael R. Kosorok

Personalized decision-making, aiming to derive optimal treatment regimes based on individual characteristics, has recently attracted increasing attention in many fields, such as medicine, social services, and economics. Current literature…

Methodology · Statistics 2023-02-28 Jianing Chu , Wenbin Lu , Shu Yang

Diagnosing rare diseases presents a common challenge in clinical practice, necessitating the expertise of specialists for accurate identification. The advent of machine learning offers a promising solution, while the development of such…

Machine Learning · Computer Science 2024-03-12 Yifan Wu , Yang Liu , Yue Yang , Michael S. Yao , Wenli Yang , Xuehui Shi , Lihong Yang , Dongjun Li , Yueming Liu , James C. Gee , Xuan Yang , Wenbin Wei , Shi Gu

Machine learning solutions for pattern classification problems are nowadays widely deployed in society and industry. However, the lack of transparency and accountability of most accurate models often hinders their safe use. Thus, there is a…

Machine Learning · Computer Science 2021-12-24 Gonzalo Nápoles , Yamisleydi Salgueiro , Isel Grau , Maikel Leon Espinosa