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Foundation models provide robust embeddings for diverse tasks, including medical imaging. We evaluate embeddings from seven general and medical-specific foundation models (e.g., DenseNet121, BiomedCLIP, MedImageInsight, Rad-DINO,…

Large vision foundation models have been widely adopted for retinal disease classification without systematic evidence justifying their parameter requirements. In the present work we address two critical questions: First, are large…

Image and Video Processing · Electrical Eng. & Systems 2025-12-01 David Isztl , Tahm Spitznagel , Gabor Mark Somfai , Rui Santos

The recent surge of foundation models in computer vision and natural language processing opens up perspectives in utilizing multi-modal clinical data to train large models with strong generalizability. Yet pathological image datasets often…

Computer Vision and Pattern Recognition · Computer Science 2023-07-28 Yunkun Zhang , Jin Gao , Mu Zhou , Xiaosong Wang , Yu Qiao , Shaoting Zhang , Dequan Wang

Foundation models (FMs) have emerged as a transformative paradigm in medical image analysis, offering the potential to provide generalizable, task-agnostic solutions across a wide range of clinical tasks and imaging modalities. Their…

Computer Vision and Pattern Recognition · Computer Science 2025-11-04 Karma Phuntsho , Abdullah , Kyungmi Lee , Ickjai Lee , Euijoon Ahn

Training AI foundation models has emerged as a promising large-scale learning approach for addressing real-world healthcare challenges, including digital pathology. While many of these models have been developed for tasks like disease…

Computer Vision and Pattern Recognition · Computer Science 2025-11-11 Junlin Guo , Siqi Lu , Can Cui , Ruining Deng , Tianyuan Yao , Zhewen Tao , Yizhe Lin , Marilyn Lionts , Quan Liu , Juming Xiong , Yu Wang , Shilin Zhao , Catie Chang , Mitchell Wilkes , Mengmeng Yin , Haichun Yang , Yuankai Huo

Foundation models are a current focus of attention in both industry and academia. While they have shown their capabilities in a variety of tasks, in-depth research is required to determine their robustness to distribution shift when used as…

Computation and Language · Computer Science 2023-12-12 Xiruo Ding , Zhecheng Sheng , Brian Hur , Feng Chen , Serguei V. S. Pakhomov , Trevor Cohen

Accurate wound classification and boundary segmentation are essential for guiding clinical decisions in both chronic and acute wound management. However, most existing AI models are limited, focusing on a narrow set of wound types or…

Computer Vision and Pattern Recognition · Computer Science 2026-03-31 Mehedi Hasan Tusar , Fateme Fayyazbakhsh , Igor Melnychuk , Ming C. Leu

Herbicide field trials require accurate identification of plant species and assessment of herbicide-induced damage across diverse environments. While general-purpose vision foundation models have shown promising results in complex visual…

Computer Vision and Pattern Recognition · Computer Science 2025-11-07 Leire Benito-Del-Valle , Artzai Picón , Daniel Mugica , Manuel Ramos , Eva Portillo , Javier Romero , Carlos Javier Jimenez , Ramón Navarra-Mestre

The study of security in machine learning mainly focuses on downstream task-specific attacks, where the adversarial example is obtained by optimizing a loss function specific to the downstream task. At the same time, it has become standard…

Computer Vision and Pattern Recognition · Computer Science 2025-03-07 Brian Pulfer , Yury Belousov , Vitaliy Kinakh , Teddy Furon , Slava Voloshynovskiy

Federated learning (FL) is increasingly used to fine-tune foundation models (FMs) on distributed private data. The community largely assumes that large-scale pretraining serves as a 'rising tide that lifts all boats' in federated settings.…

Machine Learning · Computer Science 2026-05-12 Kiran Naseer , Umar Shoaib

Vision-language models trained with contrastive learning on paired medical images and reports show strong zero-shot diagnostic capabilities, yet the effect of training batch composition on learned representations remains unexplored for 3D…

Computer Vision and Pattern Recognition · Computer Science 2026-04-16 Shivika , Kartik Bose , Pankaj Gupta

Healthcare foundation models have largely followed paradigms from natural language processing and computer vision, emphasizing large scale pretraining and deterministic representations over heterogeneous clinical data. However, clinical…

Machine Learning · Computer Science 2026-04-07 Qian Zhou , Yuanyun Zhang , Shi Li

Foundation models (FMs) have shown transformative potential in radiology by performing diverse, complex tasks across imaging modalities. Here, we developed CT-FM, a large-scale 3D image-based pre-trained model designed explicitly for…

Image and Video Processing · Electrical Eng. & Systems 2025-02-27 Suraj Pai , Ibrahim Hadzic , Dennis Bontempi , Keno Bressem , Benjamin H. Kann , Andriy Fedorov , Raymond H. Mak , Hugo J. W. L. Aerts

Deep learning has led to remarkable advancements in computational histopathology, e.g., in diagnostics, biomarker prediction, and outcome prognosis. Yet, the lack of annotated data and the impact of batch effects, e.g., systematic technical…

Machine Learning · Computer Science 2024-11-11 Jonah Kömen , Hannah Marienwald , Jonas Dippel , Julius Hense

Trauma is a significant cause of mortality and disability, particularly among individuals under forty. Traditional diagnostic methods for traumatic injuries, such as X-rays, CT scans, and MRI, are often time-consuming and dependent on…

Image and Video Processing · Electrical Eng. & Systems 2024-07-24 Liheng Jiang , Xuechun yang , Chang Yu , Zhizhong Wu , Yuting Wang

The non-invasive assessment of increasingly incidentally discovered renal masses is a critical challenge in urologic oncology, where diagnostic uncertainty frequently leads to the overtreatment of benign or indolent tumors. In this study,…

While large pretrained foundation models (FMs) have shown remarkable zero-shot classification robustness to dataset-level distribution shifts, their robustness to subpopulation or group shifts is relatively underexplored. We study this…

Machine Learning · Computer Science 2022-07-18 Michael Zhang , Christopher Ré

Foundation models (FMs) have demonstrated strong transferability across medical imaging tasks, yet their clinical utility depends critically on how pretrained representations are adapted to domain-specific data, supervision regimes, and…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Karma Phuntsho , Abdullah , Kyungmi Lee , Ickjai Lee , Euijoon Ahn

Pathology foundation models (PFMs) have become central to computational pathology, aiming to offer general encoders for feature extraction from whole-slide images (WSIs). Despite strong benchmark performance, PFM robustness to real-world…

Image and Video Processing · Electrical Eng. & Systems 2026-01-08 Erik Thiringer , Fredrik K. Gustafsson , Kajsa Ledesma Eriksson , Mattias Rantalainen

Frailty is a condition in aging medicine characterized by diminished physiological reserve and increased vulnerability to stressors. However, frailty assessment remains subjective, heterogeneous, and difficult to scale in clinical practice.…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Laura McDaniel , Basudha Pal , Crystal Szczesny , Yuxiang Guo , Zhaoyang Wang , Ryan Roemmich , Peter Abadir , Rama Chellappa
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