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Single-cell multi-omics data contain huge information of cellular states, and analyzing these data can reveal valuable insights into cellular heterogeneity, diseases, and biological processes. However, as cell differentiation \& development…

Genomics · Quantitative Biology 2025-08-27 Wuchao Liu , Han Peng , Wengen Li , Yichao Zhang , Jihong Guan , Shuigeng Zhou

Robust prediction of citywide traffic flows at different time periods plays a crucial role in intelligent transportation systems. While previous work has made great efforts to model spatio-temporal correlations, existing methods still…

Machine Learning · Computer Science 2024-03-07 Jiahao Ji , Jingyuan Wang , Chao Huang , Junjie Wu , Boren Xu , Zhenhe Wu , Junbo Zhang , Yu Zheng

Single-cell gene expression measurements encode variability spanning molecular noise, cell-to-cell heterogeneity, and technical artifacts. Mechanistic stochastic models provide powerful approaches to disentangle these sources, yet inferring…

Quantitative Methods · Quantitative Biology 2025-09-19 Christopher E. Miles

We present Speculative Rollout with Tree-Structured Cache (SRT), a simple, model-free approach to accelerate on-policy reinforcement learning (RL) for language models without sacrificing distributional correctness. SRT exploits the…

Machine Learning · Computer Science 2026-01-15 Chi-Chih Chang , Siqi Zhu , Zhichen Zeng , Haibin Lin , Jiaxuan You , Mohamed S. Abdelfattah , Ziheng Jiang , Xuehai Qian

High-resolution spatial transcriptomics (HR-ST) technologies offer unprecedented insights into tissue architecture but lack standardized frameworks for histological annotation. We present ST2HE, a cross-platform generative framework that…

Quantitative Methods · Quantitative Biology 2025-10-16 Zhentao Liu , Arun Das , Wen Meng , Yu-Chiao Chiu , Shou-Jiang Gao , Yufei Huang

The growing demands on GPU memory posed by the increasing number of neural network parameters call for training approaches that are more memory-efficient. Previous memory reduction training techniques, such as Low-Rank Adaptation (LoRA) and…

Machine Learning · Computer Science 2025-08-14 Jialin Zhao , Yingtao Zhang , Xinghang Li , Huaping Liu , Carlo Vittorio Cannistraci

Spatial transcriptomics (ST) maps gene expression within tissue at individual spots, making it a valuable resource for multimodal representation learning. Additionally, ST inherently contains rich hierarchical information both across and…

Computer Vision and Pattern Recognition · Computer Science 2025-03-04 Xulin Chen , Junzhou Huang

Distribution Regression (DR) on stochastic processes describes the learning task of regression on collections of time series. Path signatures, a technique prevalent in stochastic analysis, have been used to solve the DR problem. Recent…

Machine Learning · Computer Science 2024-10-15 Andrew Alden , Carmine Ventre , Blanka Horvath

Efficiently capturing the complex spatiotemporal representations from large-scale unlabeled traffic data remains to be a challenging task. In considering of the dilemma, this work employs the advanced contrastive learning and proposes a…

Machine Learning · Computer Science 2023-12-19 Lincan Li , Kaixiang Yang , Fengji Luo , Jichao Bi

Spatio-temporal forecasting is fundamental to intelligent systems in transportation, climate science, and urban planning. However, training deep learning models on the massive, often redundant, datasets from these domains presents a…

Machine Learning · Computer Science 2026-03-03 Wei Chen , Junle Chen , Yuqian Wu , Yuxuan Liang , Xiaofang Zhou

Single-cell transcriptomics and proteomics have become a great source for data-driven insights into biology, enabling the use of advanced deep learning methods to understand cellular heterogeneity and gene expression at the single-cell…

Genomics · Quantitative Biology 2025-12-15 Hiren Madhu , João Felipe Rocha , Tinglin Huang , Siddharth Viswanath , Smita Krishnaswamy , Rex Ying

Understanding how cellular morphology, gene expression, and spatial context jointly shape tissue function is a central challenge in biology. Image-based spatial transcriptomics technologies now provide high-resolution measurements of cell…

Quantitative Methods · Quantitative Biology 2026-02-17 Zhenglun Kong , Mufan Qiu , John Boesen , Xiang Lin , Sukwon Yun , Tianlong Chen , Manolis Kellis , Marinka Zitnik

The intrinsic dynamics and event-driven nature of spiking neural networks (SNNs) make them excel in processing temporal information by naturally utilizing embedded time sequences as time steps. Recent studies adopting this approach have…

Machine Learning · Computer Science 2024-12-18 Jiaqi Wang , Liutao Yu , Liwei Huang , Chenlin Zhou , Han Zhang , Zhenxi Song , Min Zhang , Zhengyu Ma , Zhiguo Zhang

Skeleton-based action recognition has made great progress recently, but many problems still remain unsolved. For example, most of the previous methods model the representations of skeleton sequences without abundant spatial structure…

Computer Vision and Pattern Recognition · Computer Science 2018-12-04 Chenyang Si , Ya Jing , Wei Wang , Liang Wang , Tieniu Tan

Spatial Transcriptomics (ST) is a technology that measures gene expression profiles within tissue sections while retaining spatial context. It reveals localized gene expression patterns and tissue heterogeneity, both of which are essential…

Quantitative Methods · Quantitative Biology 2026-03-24 Wei Zhang , Jiajun Chu , Xinci Liu , Chen Tong , Xinyue Li

Computed tomography (CT) imaging could be very practical for diagnosing various diseases. However, the nature of the CT images is even more diverse since the resolution and number of the slices of a CT scan are determined by the machine and…

Image and Video Processing · Electrical Eng. & Systems 2022-07-11 Chih-Chung Hsu , Chi-Han Tsai , Guan-Lin Chen , Sin-Di Ma , Shen-Chieh Tai

Spatial transcriptomics (ST) has advanced significantly in the last few years. Such advancement comes with the urgent need for novel computational methods to handle the unique challenges of ST data analysis. Many artificial intelligence…

Machine Learning · Computer Science 2022-03-21 Yijun Li , Stefan Stanojevic , Lana X. Garmire

Spatio-Temporal prediction plays a critical role in smart city construction. Jointly modeling multiple spatio-temporal tasks can further promote an intelligent city life by integrating their inseparable relationship. However, existing…

Machine Learning · Computer Science 2023-04-20 Zijian Zhang , Xiangyu Zhao , Hao Miao , Chunxu Zhang , Hongwei Zhao , Junbo Zhang

Single-cell representation learning (SCRL) from gene expression data offers a way to uncover the complex regulatory logic underlying cellular function. Inspired by large language models in natural language modeling, several single-cell…

Machine Learning · Computer Science 2026-05-11 Sachini Weerasekara , Natasha Darras , Sagar Kamarthi , Colles Price , Jacqueline Isaacs

While reinforcement learning (RL) methods that learn an internal model of the environment have the potential to be more sample efficient than their model-free counterparts, learning to model raw observations from high dimensional sensors…

Machine Learning · Computer Science 2023-06-27 Raj Ghugare , Homanga Bharadhwaj , Benjamin Eysenbach , Sergey Levine , Ruslan Salakhutdinov
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