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The Model Context Protocol (MCP) enables large language models to invoke external tools through natural-language descriptions, forming the foundation of many AI agent applications. However, MCP does not enforce consistency between…

Cryptography and Security · Computer Science 2026-02-04 Zhihao Li , Boyang Ma , Xuelong Dai , Minghui Xu , Yue Zhang , Biwei Yan , Kun Li

The Model Context Protocol (MCP) has been proposed as a unifying standard for connecting large language models (LLMs) with external tools and resources, promising the same role for AI integration that HTTP and USB played for the Web and…

Computers and Society · Computer Science 2025-11-18 Hechuan Guo , Yongle Hao , Yue Zhang , Minghui Xu , Peizhuo Lv , Jiezhi Chen , Xiuzhen Cheng

Large Language Models (LLMs) are increasingly augmented with external tools through standardized interfaces like the Model Context Protocol (MCP). However, current MCP implementations face critical limitations: they typically require local…

Cryptography and Security · Computer Science 2026-03-11 Arash Ahmadi , Sarah Sharif , Yaser M. Banad

Autonomous systems that generate scientific hypotheses, conduct experiments, and draft manuscripts have recently emerged as a promising paradigm for accelerating discovery. However, existing AI Scientists remain largely domain-agnostic,…

Artificial Intelligence · Computer Science 2026-03-31 Hongtao Wu , Boyun Zheng , Dingjie Song , Yu Jiang , Jianfeng Gao , Lei Xing , Lichao Sun , Yixuan Yuan

The Model Context Protocol (MCP) enables large language models (LLMs) to dynamically discover and invoke third-party tools, significantly expanding agent capabilities while introducing a distinct security landscape. Unlike prompt-only…

Cryptography and Security · Computer Science 2026-04-10 Mehrdad Rostamzadeh , Sidhant Narula , Nahom Birhan , Mohammad Ghasemigol , Daniel Takabi

This paper contributes with a pragmatic evaluation framework for explainable Machine Learning (ML) models for clinical decision support. The study revealed a more nuanced role for ML explanation models, when these are pragmatically embedded…

Artificial Intelligence · Computer Science 2022-12-22 Oskar Wysocki , Jessica Katharine Davies , Markel Vigo , Anne Caroline Armstrong , Dónal Landers , Rebecca Lee , André Freitas

The Model Context Protocol (MCP) has emerged as the de facto standard for connecting Large Language Models (LLMs) to external data and tools, effectively functioning as the "USB-C for Agentic AI." While this decoupling of context and…

Cryptography and Security · Computer Science 2025-12-16 Shiva Gaire , Srijan Gyawali , Saroj Mishra , Suman Niroula , Dilip Thakur , Umesh Yadav

The Human Cognitive Simulation Framework proposes a governed cognitive AI architecture designed to improve personalization, adaptability, and long-term coherence in human AI interaction. The framework integrates short-term memory…

Human-Computer Interaction · Computer Science 2026-01-23 Rommel Salas-Guerra

We introduce SCP: the Science Context Protocol, an open-source standard designed to accelerate discovery by enabling a global network of autonomous scientific agents. SCP is built on two foundational pillars: (1) Unified Resource…

As Large Language Models (LLMs) evolve from passive text generators to active reasoning agents capable of interacting with external tools, the Model Context Protocol (MCP) has emerged as a key standardized framework for dynamic tool…

Artificial Intelligence · Computer Science 2025-10-14 Xuanqi Gao , Siyi Xie , Juan Zhai , Shiqing Ma , Chao Shen

Artificial intelligence (AI) has demonstrated strong potential in clinical diagnostics, often achieving accuracy comparable to or exceeding that of human experts. A key challenge, however, is that AI reasoning frequently diverges from…

Artificial Intelligence · Computer Science 2026-05-25 Belona Sonna , Alban Grastien

We present AgentOptics, an agentic AI framework for high-fidelity, autonomous optical system control built on the Model Context Protocol (MCP). AgentOptics interprets natural language tasks and executes protocol-compliant actions on…

AI assistants can decompose multi-step workflows, but they do not natively speak industrial protocols such as Modbus, MQTT/Sparkplug B, or OPC UA, so this paper presents INDUSTRICONNECT, a prototype suite of Model Context Protocol (MCP)…

Software Engineering · Computer Science 2026-03-27 Melwin Xavier , Melveena Jolly , Vaisakh M A , Midhun Xavier

Context parallelism has emerged as a key technique to support long-context training, a growing trend in generative AI for modern large models. However, existing context parallel methods rely on static parallelization configurations that…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-10-14 Chenyu Jiang , Zhenkun Cai , Ye Tian , Zhen Jia , Yida Wang , Chuan Wu

Bioinformatics web servers are critical resources in modern biomedical research, facilitating interactive exploration of datasets through custom-built interfaces with rich visualization capabilities. However, this human-centric design…

Other Quantitative Biology · Quantitative Biology 2026-02-25 Matthias Flotho , Ian Ferenc Diks , Philipp Flotho , Leidy-Alejandra G. Molano , Pascal Hirsch , Andreas Keller

Tool calling has emerged as a critical capability for AI agents. In contrast to conventional tool calling frameworks that rely on static, provider-specific tool definitions, the Model Context Protocol (MCP) offers a unified interface to…

The AI agent ecosystem has converged on two protocols: the Model Context Protocol (MCP) for tool invocation and Agent-to-Agent (A2A) for single-principal task delegation. Both assume a single controlling principal, meaning one person or…

Multiagent Systems · Computer Science 2026-04-14 Kaiyang Qian , Xinmin Fang , Zhengxiong Li

Accurate disease prediction is vital for timely intervention, effective treatment, and reducing medical complications. While symbolic AI has been applied in healthcare, its adoption remains limited due to the effort required for…

Artificial Intelligence · Computer Science 2026-01-01 Ioanna Gemou , Evangelos Lamprou

The Observational Medical Outcomes Partnership (OMOP) common data model (CDM) provides a standardized representation of heterogeneous health data to support large-scale, multi-institutional research. One critical step in data…

Artificial Intelligence · Computer Science 2025-09-05 Jaerong Ahn , Andrew Wen , Nan Wang , Heling Jia , Zhiyi Yue , Sunyang Fu , Hongfang Liu

Multimodal artificial intelligence (AI) systems have the potential to enhance clinical decision-making by interpreting various types of medical data. However, the effectiveness of these models across all medical fields is uncertain. Each…