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Large Language Models (LLMs) are increasingly integrated into real-world applications via the Model Context Protocol (MCP), a universal open standard for connecting AI agents with data sources and external tools. While MCP enhances the…

Cryptography and Security · Computer Science 2026-02-13 Yixuan Yang , Cuifeng Gao , Daoyuan Wu , Yufan Chen , Yingjiu Li , Shuai Wang

Despite being trained on significant amounts of data, Large Language Models (LLMs) can provide inaccurate or unreliable information in the context of a user's specific query. Given query-specific context significantly improves the…

Computation and Language · Computer Science 2025-09-25 Millie Vyas , Timothy Blattner , Alden Dima

Generative medical AI now appears fluent and knowledgeable enough to resemble clinical intelligence, encouraging the belief that scaling will make it safe. But clinical reasoning is not text generation. It is a responsibility-bound process…

Artificial Intelligence · Computer Science 2026-02-02 Vaibhav Ram S. V. N. S , Swetanshu Agrawal , Samudra Banerjee , Abdul Muhsin

Clinical decision support systems require models that are not only highly accurate but also equitable and sensitive to the implications of missed diagnoses. In this study, we introduce a knowledge-guided in-context learning (ICL) framework…

Machine Learning · Computer Science 2025-07-28 Fatemeh Nazary , Yashar Deldjoo , Tommaso Di Noia , Eugenio di Sciascio

Screening patients for clinical trial eligibility remains a manual, time-consuming, and resource-intensive process. We present a secure, scalable proof-of-concept system for Artificial Intelligence (AI)-augmented patient-trial matching that…

The variety of data in data lakes presents significant challenges for data analytics, as data scientists must simultaneously analyze multi-modal data, including structured, semi-structured, and unstructured data. While Large Language Models…

Databases · Computer Science 2025-05-19 Chao Zhang , Shaolei Zhang , Quehuan Liu , Sibei Chen , Tong Li , Ju Fan

Artificial Intelligence (AI) has become essential in modern healthcare, with large language models (LLMs) offering promising advances in clinical decision-making. Traditional model-based approaches, including those leveraging in-context…

The Model Context Protocol (MCP) enables large language models (LLMs) to access external resources on demand. While commonly assumed to enhance performance, how LLMs actually leverage this capability remains poorly understood. We introduce…

Artificial Intelligence · Computer Science 2025-08-19 Wei Song , Haonan Zhong , Ziqi Ding , Jingling Xue , Yuekang Li

Large language models are increasingly used as orchestrators of external tools via the Model Context Protocol (MCP), but MCP is built for software services with megabytes of memory and does not descend to the microcontrollers that dominate…

Networking and Internet Architecture · Computer Science 2026-05-27 Dongxu Yang

The Model Context Protocol (MCP), introduced by Anthropic in November 2024 and now governed by the Linux Foundation's Agentic AI Foundation, has rapidly become the de facto standard for connecting large language model (LLM)-based agents to…

Cryptography and Security · Computer Science 2026-04-08 Nirajan Acharya , Gaurav Kumar Gupta

Large Language Models (LLMs) remain static in functionality after training, and extending their capabilities requires integration with external data, computation, and services. The Model Context Protocol (MCP) has emerged as a standard…

Networking and Internet Architecture · Computer Science 2025-10-16 Enhan Li , Hongyang Du , Kaibin Huang

Large Language Model (LLM) agents increasingly interact with external systems through tool-calling protocols such as the Model Context Protocol (MCP). In prevailing architectures, the agent must reason about every tool invocation in every…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-05-05 Abhinav Singh Parmar

There has been much progress in data-driven artificial intelligence technology for medical image analysis in the last decades. However, it still remains challenging due to its distinctive complexity of acquiring and annotating image data,…

Computer Vision and Pattern Recognition · Computer Science 2021-06-30 Chao Gou , Tianyu Shen , Wenbo Zheng , Huadan Xue , Hui Yu , Qiang Ji , Zhengyu Jin , Fei-Yue Wang

The increased adoption of the Model Context Protocol (MCP) for AI Agents necessitates robust security for Enterprise integrations. This paper introduces the MCP Gateway to simplify self-hosted MCP server integration. The proposed…

Cryptography and Security · Computer Science 2025-04-29 Ivo Brett

Academic advances of AI models in high-precision domains, like healthcare, need to be made explainable in order to enhance real-world adoption. Our past studies and ongoing interactions indicate that medical experts can use AI systems with…

Human-AI collaboration faces growing challenges as AI systems increasingly outperform humans on complex tasks, while humans remain responsible for orchestration, validation, and decision oversight. To address this imbalance, we introduce…

Human-Computer Interaction · Computer Science 2026-02-16 Yuanrong Tang , Huiling Peng , Bingxi Zhao , Hengyang Ding , Hanchao Song , Tianhong Wang , Chen Zhong , Jiangtao Gong

While large language models (LLMs) have shown promise in diagnostic dialogue, their capabilities for effective management reasoning - including disease progression, therapeutic response, and safe medication prescription - remain…

Clinical dialogue represents a complex duality requiring both the empathetic fluency of natural conversation and the rigorous precision of evidence-based medicine. While Large Language Models possess unprecedented linguistic capabilities,…

Other Quantitative Biology · Quantitative Biology 2025-12-02 Xiaoquan Zhi , Hongke Zhao , Likang Wu , Chuang Zhao , Hengshu Zhu

The Model Context Protocol (MCP) is emerging as a standard interface through which large language model (LLM) agents discover and invoke external tools. However, existing MCP evaluations fall short along three key axes: realistic multi-step…

The integration of Large Language Models (LLMs) with Internet-of-Things (IoT) systems faces significant challenges in hardware heterogeneity and control complexity. The Model Context Protocol (MCP) emerges as a critical enabler, providing…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-10-03 Ningyuan Yang , Guanliang Lyu , Mingchen Ma , Yiyi Lu , Yiming Li , Zhihui Gao , Hancheng Ye , Jianyi Zhang , Tingjun Chen , Yiran Chen