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We demonstrate a method to double the collection efficiency in Laser Tweezers Raman Spectroscopy (LTRS) by collecting both the forward and back-scattered light in a single-shot multitrack measurement. Our method can collect signals at…

Optics · Physics 2021-06-09 Tobias Dahlberg , Magnus Andersson

In the shock-ignition inertial confinement fusion scheme, high-intensity lasers propagate through an inhomogeneous coronal plasma, driving a shock designed to cause fuel ignition. During the high-intensity ignitor laser pulse, SRS…

Plasma Physics · Physics 2020-11-25 SJ Spencer , Alexander Seaton , Tom Goffrey , Tony Arber

The spike protein (SP) of SARS-CoV-2 is the major molecular target for making diagnostic tests, vaccines, and therapeutic development. We used a combination of transmission electron microscopy (TEM) and surface enhanced Raman microscopy…

Biological Physics · Physics 2025-01-30 Monika Ghalawat , Virendra Kumar Meena , Sharda Prasad , Pankaj Poddar , Atanu Basu

Noise manifests ubiquitously in nonlinear spectroscopy, where multiple sources contribute to experimental signals generating interrelated unwanted components, from random point-wise fluctuations to structured baseline signals. Mitigating…

Surface enhanced Raman scattering (SERS) in nanoscale hotspots has been placed great hopes upon for identification of minimum chemical traces and in-situ investigation of single molecule structures and dynamics. However, previous work…

Optics · Physics 2016-09-19 Jing Long , Hui Yi , Hongquan Li , Tian Yang

Raman spectroscopy provides spectral information related to the specific molecular structures of substances and has been well established as a powerful tool for studying biological tissues and diagnosing diseases. This article reviews…

Highly ordered periodic arrays of silver nanoparticles have been fabricated which exhibit surface plasmon resonances in the visible spectrum. We demonstrate the ability of these structures to alter the fluorescence properties of vicinal dye…

Other Condensed Matter · Physics 2009-11-13 Nic Cade , Tom Ritman-Meer , David Richards

Here we show how surface-enhanced Raman spectroscopy (SERS) features can be fine-tuned in optically active substrates made of layered materials. To demonstrate this, we used DNA-assisted lithography (DALI) to create substrates with silver…

Implicit representation mapping (IRM) can translate image features to any continuous resolution, showcasing its potent capability for ultra-high-resolution image segmentation refinement. Current IRM-based methods for refining…

Computer Vision and Pattern Recognition · Computer Science 2024-08-01 Ziyu Zhao , Xiaoguang Li , Pingping Cai , Canyu Zhang , Song Wang

Wide field Raman imaging using the integral field spectroscopy approach was used as a fast, one shot imaging method for the simultaneous collection of all spectra composing a Raman image. For the suppression of autofluorescence and…

Raman spectroscopy is an important tool in the study of vibrational properties and composition of molecules, peptides and even proteins. Raman spectra can be simulated based on the change of the electronic polarizability with vibrations,…

Computational Physics · Physics 2024-04-30 Ethan Berger , Juha Niemelä , Outi Lampela , André H. Juffer , Hannu-Pekka Komsa

A major open challenge in neuroscience is the ability to measure and perturb neural activity in vivo from well-defined neural sub-populations at cellular resolution anywhere in the brain. However, limitations posed by scattering and…

Biological Physics · Physics 2017-11-10 Shay Ohayon , Antonio Miguel Caravaca-Aguirre , Rafael Piestun , James J. DiCarlo

Intracellular lasers are emerging as powerful biosensors for multiplexed tracking and precision sensing of cells and their microenvironment. This sensing capacity is enabled by quantifying their narrow-linewidth emission spectra, which is…

We theoretically investigate the enhancement of surface enhanced Raman spectroscopy (SERS) using hyperbolic stratified nanostructures and compare to metal nanoresonators. The photon Green function of each nanostructure within its…

Miniaturized spectrometers for Raman spectroscopy have the potential to open up a new chapter in sensing. Raman spectroscopy is essential for material characterization and biomedical diagnostics, however, its weak signal and the need for…

Deep, high-resolution imaging is essential for unraveling biological complexity and advancing medical diagnostics, yet scattering fundamentally limits optical methods. Among the most promising approaches, photoacoustic imaging achieves…

As the silicon industry continues to push the limits of device dimensions, tools such as Raman spectroscopy are ideal to analyze and characterize the doped silicon channels. The effect of inter-valence band transitions on the zone center…

Materials Science · Physics 2015-05-14 Brian G. Burke , Jack Chan , Keith A. Williams , Zili Wu , Alexander A. Puretzky , David B. Geohegan

Magnetic Resonance Force Microscopy (MRFM) enables three-dimensional imaging of nuclear spin densities in nanoscale objects. Based on numerical simulations, we evaluate the performance of strained SiN resonators as force sensors and show…

Applied Physics · Physics 2026-04-15 Nils Prumbaum , Christian L. Degen , Alexander Eichler

We introduce a single-frame diffractive imaging method called randomized probe imaging (RPI). In RPI, a sample is illuminated by a structured probe field containing speckles smaller than the sample's typical feature size. Quantitative…

We report a detailed study of the strong near-field Raman scattering enhancement which takes place in tip-enhanced Raman scattering (TERS) in indium nitride. In addition to the well-known first-order optical phonons of indium nitride,…