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Objective: Real-time adaptive proton range verification systems based on produced neutrons require accurate information on their non-isotropic momentum distributions within short times, for which Monte Carlo (MC) methods are too…

Depth distributions of positron-emitting nuclei in PMMA phantoms are calculated within a Monte Carlo model for Heavy-Ion Therapy (MCHIT) based on the GEANT4 toolkit (version 8.0). The calculated total production rates of $^{11}$C, $^{10}$C…

Medical Physics · Physics 2007-05-23 Igor Pshenichnov , Igor Mishustin , Walter Greiner

Proton beam radiotherapy stands at the forefront of precision cancer treatment, leveraging the unique physical interactions of proton beams with human tissue to deliver minimal dose upon entry and deposit the therapeutic dose precisely at…

Purpose: The purpose of this work was to provide a flexible platform for FLASH research with protons by adapting a former clinical pencil beam scanning gantry to irradiations with ultrahigh dose rates. Methods: PSI Gantry 1 treated patients…

Monte Carlo simulation is the most accurate method for absorbed dose calculations in radiotherapy. Its efficiency still requires improvement for routine clinical applications, especially for online adaptive radiotherapy. In this paper, we…

Medical Physics · Physics 2015-05-14 Xun Jia , Xuejun Gu , Josep Sempau , Dongju Choi , Amitava Majumdar , Steve B. Jiang

Several models for the simulation of photon elastic scattering are quantitatively evaluated with respect to a large collection of experimental data retrieved from the literature. They include models based on the form factor approximation,…

Computational Physics · Physics 2012-09-27 Matej Batic , Gabriela Hoff , Maria Grazia Pia , Paolo Saracco

We test the feasibility of calculating proton stopping power (SP) from a set of virtual monochromatic (VM) CT images, created with Monte Carlo-generated CT scans, using a dual-energy CT-to-SP procedure. The Monte Carlo CT simulations, with…

Medical Physics · Physics 2022-06-23 Adam Zieser , Ugur Akgun , Yasar Onel

A radiographic setup for an investigation of fast dynamic processes with areal density of targets up to 5 g/cm$^2$ is under development on the basis of high-current proton linear accelerator at the Institute for Nuclear Research (Troitsk,…

Monte Carlo simulations are increasingly used in scintigraphic imaging to model imaging systems and to develop and assess tomographic reconstruction algorithms and correction methods for improved image quantitation. GATE (GEANT 4…

Instrumentation and Detectors · Physics 2009-11-10 D. Lazaro , I. Buvat , G. Loudos , D. Strul , G. Santin , N. Giokaris , D. Donnarieix , L. Maigne , V. Spanoudaki , S. Styliaris , S. Staelens , V. Breton

Geant4 simulations play a crucial role in the analysis and interpretation of experiments providing low energy precision tests of the Standard Model. This paper focuses on the accuracy of the description of the electron processes in the…

Instrumentation and Detectors · Physics 2013-08-23 G. Soti , F. Wauters , M. Breitenfeldt , P. Finlay , I. S. Kraev , A. Knecht , T. Porobic , D. Zákoucký , N. Severijns

Purpose: To validate the accuracy of 4D Monte Carlo (4DMC) simulations to calculate dose deliveries to a deforming anatomy in the presence of realistic respiratory motion traces. A previously developed deformable lung phantom comprising an…

Medical Physics · Physics 2023-05-04 Sara Gholampourkashi , Joanna E. Cygler , Bernie Lavigne , Emily Heath

In this work, we propose a novel technique for in-vivo proton therapy range verification. This technique makes use of a small hadron tumour marker, $^{92}$Mo, implanted at a short known distance from the clinical treatment volume. Signals…

A new model for the nuclear elastic scattering of protons below 250 MeV has been recently included in FLUKA v4-4.0, motivated by the evaluation of radiation effects in electronics. Nonetheless, proton nuclear elastic scattering plays a…

The claim that Monte Carlo is the most accurate method is a case of misattributed credit. This claim is based on experience with advanced systems MCNPX, Geant4 and EGS. These systems achieve remarkable performance because they use most…

Medical Physics · Physics 2026-03-13 Oleg N Vassiliev , Radhe Mohan

Given the unprecedented effective area, the new ATHENA Silicon Pore Optics (SPO) focusing technology, the dynamic and variable L2 environment, where no X-ray mission has flown up to date, a dedicated Geant4 simulation campaign is needed to…

Instrumentation and Methods for Astrophysics · Physics 2018-06-13 Valentina Fioretti , Andrea Bulgarelli , Simone Lotti , Claudio Macculi , Teresa Mineo , Luigi Piro , Debora Bruno , Massimo Cappi , Mauro Dadina

Monte Carlo (MC) simulation is commonly considered to be the most accurate dose calculation method in radiotherapy. However, its efficiency still requires improvement for many routine clinical applications. In this paper, we present our…

Medical Physics · Physics 2015-05-28 Xun Jia , Xuejun Gu , Yan Jiang Graves , Michael Folkerts , Steve B. Jiang

We are exploring low-dose proton radiography and computed tomography (pCT) as techniques to improve the accuracy of proton treatment planning and to provide artifact-free images for verification and adaptive therapy at the time of…

Radiotherapy of pregnant cancer patients is not common, but when applied accurate assessment of the fetus dose is required, especially since the treatment planning systems are not able and do not allow accurate assessment of out-of-field…

Medical Physics · Physics 2021-12-08 Marijke De Saint-Hubert , Katarzyna Tyminska , Liliana Stolarczyk , Hrvoje Brkic

Objective. Proton beams enable localized dose delivery. Accurate range estimation is essential, but planning still relies on X-ray CT, which introduces uncertainty in stopping power and range. Proton CT measures water equivalent thickness…

Medical Physics · Physics 2025-09-15 Atiq Ur Rahman , Chun-Chieh Wang , Shu-Wei Wu , Tsi-Chian Chao , I-Chun Cho

The purpose of this study was to investigate the feasibility of extracting proton beams with two distinct energies within a single synchrotron cycle. The energy difference between the beams should be sufficient to use one beam as a range…

Accelerator Physics · Physics 2025-06-25 Alexander A. Pryanichnikov , Dmitry Shwartz , Jon Feldmand , Joao Seco , Maria Francesca Spadea