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Dual-energy computed tomography (DECT) is a promising technology that has shown a number of clinical advantages over conventional X-ray CT, such as improved material identification, artifact suppression, etc. For proton therapy treatment…

Monocular depth estimation (MDE) has been widely adopted in the perception systems of autonomous vehicles and mobile robots. However, existing approaches often struggle to maintain temporal consistency in depth estimation across consecutive…

Computer Vision and Pattern Recognition · Computer Science 2026-04-03 Leezy Han , Seunggyu Kim , Dongseok Shim , Hyeonbeom Lee

Purpose: To demonstrate the feasibility of fast Monte Carlo (MC) based inverse biological planning for the treatment of head and neck tumors in spot-scanning proton therapy. Methods: Recently, a fast and accurate Graphics Processor Unit…

Medical Physics · Physics 2016-10-11 H. Wan Chan Tseung , J. Ma , C. R. Kreofsky , D. Ma , C. Beltran

Background: Ultra-high dose rate proton therapy shows promise in tissue sparing by enhancing therapeutic ratio through the FLASH effect. In radiotherapy, accurate in vivo dosimetry is crucial for quality assurance, but remains challenging…

Radioactive decays are of concern in a wide variety of applications using Monte-Carlo simulations. In order to properly estimate the quality of such simulations, knowledge of the accuracy of the decay simulation is required. We present a…

The Latent Stochastic Differential Equation (SDE) is a powerful tool for time series and sequence modeling. However, training Latent SDEs typically relies on adjoint sensitivity methods, which depend on simulation and backpropagation…

Machine Learning · Statistics 2025-06-27 Grigory Bartosh , Dmitry Vetrov , Christian A. Naesseth

Recently, shoot-through proton FLASH has been proposed where the highest energy is extracted from the cyclotron to maximize the dose rate (DR). Even though our proton pencil beam scanning system can deliver 250 MeV (the highest energy), it…

Medical Physics · Physics 2023-01-26 Serdar Charyyev , Chih-Wei Chang , Mingyao Zhu , Liyong Lin , Katja Langen , Anees Dhabaan

Recent laser-plasma experiments report the existence of dynamically significant magnetic fields, whose statistical characterisation is essential for understanding the physical processes these experiments are attempting to investigate. In…

Geant4-based simulations of the energy deposited by electrons in various materials are quantitatively compared to high precision calorimetric measurements taken at Sandia Laboratories. The experimental data concern electron beams of energy…

Computational Physics · Physics 2015-06-16 Matej Batic , Gabriela Hoff , Maria Grazia Pia , Paolo Saracco , Georg Weidenspointner

Markov Chain Monte Carlo approach is frequently used within Bayesian framework to sample the target posterior distribution. Its efficiency strongly depends on the proposal used to build the chain. The best jump proposal is the one that…

Instrumentation and Methods for Astrophysics · Physics 2023-02-01 Mikel Falxa , Stanislav Babak , Maude Le Jeune

A neural stochastic differential equation (SDE) is an SDE with drift and diffusion terms parametrized by neural networks. The training procedure for neural SDEs consists of optimizing the SDE vector field (neural network) parameters to…

Machine Learning · Computer Science 2025-11-04 Luke Snow , Vikram Krishnamurthy

Purpose: Highlight the distinctions, both in terms of concept and numerical values, of the various definitions that can be established for the dose rate in PBS proton therapy. Methods: In an in silico study, five definitions of the dose…

Medical Physics · Physics 2023-07-17 Sylvain Deffet , Valentin Hamaide , Edmond Sterpin

We present and analyze a micro/macro acceleration technique for the Monte Carlo simulation of stochastic differential equations (SDEs) in which there is a separation between the (fast) time-scale on which individual trajectories of the SDE…

Numerical Analysis · Mathematics 2011-11-08 Kristian Debrabant , Giovanni Samaey

Purpose: Accurate prediction of beam delivery time (BDT) is essential for operational efficiency, 4D dose calculations, and advanced proton therapy techniques. Despite its importance, no machine-specific BDT model exists for Mevion systems.…

Medical Physics · Physics 2026-02-12 Giorgio Cartechini , Francesco Giuseppe Cordoni , Mirko Unipan , Ilaria Rinaldi

Monte Carlo simulations have been performed in order to evaluate the efficiencies of several light ions identification techniques. The detection system was composed with layers of scintillating material to measure either the deposited…

Nuclear Experiment · Physics 2013-10-02 S. Salvador , M. Labalme , J. M. Fontbonne , J. Dudouet , J. Colin , D. Cussol

We propose a micro-macro parallel-in-time Parareal method for scalar McKean-Vlasov stochastic differential equations (SDEs). In the algorithm, the fine Parareal propagator is a Monte Carlo simulation of an ensemble of particles, while an…

Numerical Analysis · Mathematics 2025-10-31 Ignace Bossuyt , Stefan Vandewalle , Giovanni Samaey

Proton scattering in some water and tissue equivalent phantom materials was measured to evaluate their simulation accuracy of water and respective human biological tissues. The measurements were performed on the medical facility of the ITEP…

Medical Physics · Physics 2010-11-23 V. N. Vasiliev , V. I. Kostjuchenko , V. G. Khaybullin , S. I. Samarin , A. S. Uglov

A procedure of space proton-induced Soft Error Rate calculation based on heavy ion testing data is proposed. The approach relies on Geant4-assisted Monte Carlo simulation of the secondary particle LET spectra produced by proton…

Space Physics · Physics 2017-04-25 Artur M. Galimov , Regina M. Galimova , Gennady I. Zebrev

We study the propagation of nucleons and nuclei in tissue-like media within a Monte Carlo Model for Heavy-ion Therapy (MCHIT) based on the GEANT4 toolkit (version 8.2). The model takes into account fragmentation of projectile nuclei and…

Medical Physics · Physics 2010-11-03 Igor Pshenichnov , Igor Mishustin , Walter Greiner

Proton therapy is a modality in fast development. Characterized by a maximum dose deposition at the end of the proton trajectory followed by a sharp fall-off, proton beams can deliver a highly conformal dose to the tumor while sparing…

Medical Physics · Physics 2022-05-18 François Smekens , Nicolas Freud , Bruno Sixou , Guillaume Beslon , Jean M Létang
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