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Understanding how treatment effects vary across patient characteristics is essential for personalized medicine, yet randomized controlled trials (RCTs) are often underpowered to detect heterogeneous treatment effects (HTEs). We propose a…

Methodology · Statistics 2025-07-22 Amir Asiaee , Chiara Di Gravio , Cole Beck , Yuting Mei , Samhita Pal , Jared D. Huling

We study time-inhomogeneous episodic reinforcement learning (RL) under general function approximation and sparse rewards. We design a new algorithm, Variance-weighted Optimistic $Q$-Learning (VO$Q$L), based on $Q$-learning and bound its…

Machine Learning · Computer Science 2022-12-13 Alekh Agarwal , Yujia Jin , Tong Zhang

This study explores the learning dynamics of neural networks by analyzing the singular value decomposition (SVD) of their weights throughout training. Our investigation reveals that an orthogonal basis within each multidimensional weight's…

Machine Learning · Computer Science 2024-11-12 Daniel Coquelin , Katharina Flügel , Marie Weiel , Nicholas Kiefer , Charlotte Debus , Achim Streit , Markus Götz

Generating probabilistic forecasts of potential outcomes and individual treatment effects (ITE) is essential for risk-aware decision-making in domains such as healthcare, policy, marketing, and finance. We propose two novel methods: the…

Machine Learning · Computer Science 2025-09-24 Jef Jonkers , Jarne Verhaeghe , Glenn Van Wallendael , Luc Duchateau , Sofie Van Hoecke

Efficiently and flexibly estimating treatment effect heterogeneity is an important task in a wide variety of settings ranging from medicine to marketing, and there are a considerable number of promising conditional average treatment effect…

Machine Learning · Statistics 2023-05-10 Erik Sverdrup , Yifan Cui

In many clinical contexts, estimating effects of treatment in time-to-event data is complicated not only by confounding, censoring, and heterogeneity, but also by the presence of a cured subpopulation in which the event of interest never…

Methodology · Statistics 2026-02-06 Yuqi Li , Quinn Lanners , Matthew M. Engelhard

Estimating treatment effects from observational data is challenging due to two main reasons: (a) hidden confounding, and (b) covariate mismatch (control and treatment groups not having identical distributions). Long lines of works exist…

Machine Learning · Computer Science 2025-04-30 Praharsh Nanavati , Ranjitha Prasad , Karthikeyan Shanmugam

Average Treatment Effect (ATE) estimation is a well-studied problem in causal inference. However, it does not necessarily capture the heterogeneity in the data, and several approaches have been proposed to tackle the issue, including…

Machine Learning · Computer Science 2024-03-19 Raghavendra Addanki , Siddharth Bhandari

We propose a novel multi-task neural network approach for estimating distributional treatment effects (DTE) in randomized experiments. While DTE provides more granular insights into the experiment outcomes over conventional methods focusing…

Machine Learning · Computer Science 2025-07-11 Tomu Hirata , Undral Byambadalai , Tatsushi Oka , Shota Yasui , Shingo Uto

While developments in machine learning led to impressive performance gains on big data, many human subjects data are, in actuality, small and sparsely labeled. Existing methods applied to such data often do not easily generalize to…

Machine Learning · Computer Science 2023-04-04 Julie Jiang , Kristina Lerman , Emilio Ferrara

This paper proposes a new meta-learning method -- named HARMLESS (HAwkes Relational Meta LEarning method for Short Sequences) for learning heterogeneous point process models from short event sequence data along with a relational network.…

Machine Learning · Computer Science 2019-09-06 Yujia Xie , Haoming Jiang , Feng Liu , Tuo Zhao , Hongyuan Zha

Deep neural networks are susceptible to catastrophic forgetting when trained on sequential tasks. Various continual learning (CL) methods often rely on exemplar buffers or/and network expansion for balancing model stability and plasticity,…

Machine Learning · Computer Science 2024-01-18 Depeng Li , Tianqi Wang , Junwei Chen , Qining Ren , Kenji Kawaguchi , Zhigang Zeng

We consider the estimation of treatment effects in settings when multiple treatments are assigned over time and treatments can have a causal effect on future outcomes or the state of the treated unit. We propose an extension of the…

Econometrics · Economics 2021-06-18 Greg Lewis , Vasilis Syrgkanis

Meta-learning has been proposed as a promising machine learning topic in recent years, with important applications to image classification, robotics, computer games, and control systems. In this paper, we study the problem of using…

Systems and Control · Electrical Eng. & Systems 2025-03-04 Yunian Pan , Tao Li , Quanyan Zhu

In scenarios with long-tailed distributions, the model's ability to identify tail classes is limited due to the under-representation of tail samples. Class rebalancing, information augmentation, and other techniques have been proposed to…

Machine Learning · Computer Science 2023-10-17 Yanbiao Ma , Licheng Jiao , Fang Liu , Shuyuan Yang , Xu Liu , Lingling Li

Panel data involving longitudinal measurements of the same set of participants taken over multiple time points is common in studies to understand childhood development and disease modeling. Deep hybrid models that marry the predictive power…

Machine Learning · Computer Science 2022-03-01 Jurijs Nazarovs , Rudrasis Chakraborty , Songwong Tasneeyapant , Sathya N. Ravi , Vikas Singh

Heterogeneous treatment effects (HTEs) are commonly identified during randomized controlled trials (RCTs). Identifying subgroups of patients with similar treatment effects is of high interest in clinical research to advance precision…

Machine Learning · Computer Science 2022-12-06 Peniel N. Argaw , Elizabeth Healey , Isaac S. Kohane

Heterogeneous treatment effects, which vary according to individual covariates, are crucial in fields such as personalized medicine and tailored treatment strategies. In many applications, rather than considering the heterogeneity induced…

Methodology · Statistics 2025-08-26 Peng Wu , Pengtao Zeng , Zhaoqing Tian , Shaojie Wei

This paper introduces and analyzes a framework that accommodates general heterogeneity in regression modeling. It demonstrates that regression models with fixed or time-varying parameters can be estimated using the OLS and time-varying OLS…

Econometrics · Economics 2025-11-11 Liudas Giraitis , George Kapetanios , Yufei Li , Alexia Ventouri

Estimating causal effects of continuous treatments is a common problem in practice, for example, in studying average dose-response functions. Classical analyses typically assume that all confounders are fully observed, whereas in real-world…

Statistics Theory · Mathematics 2026-04-14 Shuyuan Chen , Peng Zhang , Yifan Cui