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Nanopore resistive pulse techniques are based on analysis of current or voltage spikes in the recorded signal. These spikes result from translocation of nanometer sized analytes through a nanopore. The most important information that needs…

Data Analysis, Statistics and Probability · Physics 2015-03-13 Nima Arjmandi , Willem Van Roy , Liesbet Lagae , Gustaaf Borghs

Purpose Nanopore-based molecular sensing and measurement, specifically Deoxyribonucleic acid (DNA) sequencing, is advancing at a fast pace. Some embodiments have matured from coarse particle counters to enabling full human genome assembly.…

Instrumentation and Detectors · Physics 2021-10-06 Mehdi Habibi , Yunus Dawji , Ebrahim Ghafar-Zadeh , Sebastian Magierowski

In the past decade superconducting nanowire single photon detectors (SNSPDs) have gradually become an indispensable part of any demanding quantum optics experiment. Until now, most SNSPDs are coupled to single-mode fibers. SNSPDs coupled to…

Proteins are the active working horses in our body. These biomolecules perform all vital cellular functions from DNA replication and general biosynthesis to metabolic signaling and environmental sensing. While static 3D structures are now…

Quantitative Methods · Quantitative Biology 2020-10-16 Sonja Schmid , Cees Dekker

Magnetic nanoparticles (MNPs) have been extensively used as contrasts and tracers for bioimaging, heating sources for tumor therapy, carriers for controlled drug delivery, and labels for magnetic immunoassays. Here, we describe a MNP…

Applied Physics · Physics 2019-09-11 Kai Wu , Jinming Liu , Diqing Su , Renata Saha , Jian-Ping Wang

Controlled breakdown has recently emerged as a highly accessible technique to fabricate solid-state nanopores. However, in its most common form, controlled breakdown creates a single nanopore at an arbitrary location in the membrane. Here,…

Multi-port beamsplitters are cornerstone devices for high-dimensional quantum information tasks, which can outperform the two-dimensional ones. Nonetheless, the fabrication of such devices has been proven to be challenging with progress…

Creating plasmonic nanoparticles on a tapered optical fiber tip enables a remote SERS sensing probe, ideal for challenging sampling scenarios like biological tissue, specific cells, on-site environmental monitoring, and deep brain…

Hybrid photonic integration exploits complementary strengths of different material platforms, thereby offering superior performance and design flexibility in comparison to monolithic approaches. This applies in particular to multi-chip…

We present results from a new approach to learning and plasticity in neuromorphic hardware systems: to enable flexibility in implementable learning mechanisms while keeping high efficiency associated with neuromorphic implementations, we…

Neurons and Cognition · Quantitative Biology 2016-10-14 Simon Friedmann , Johannes Schemmel , Andreas Gruebl , Andreas Hartel , Matthias Hock , Karlheinz Meier

Nanophotonics provides the ability to rapidly and precisely reconfigure light beams on a compact platform. Infrared nanophotonic devices are widely used in data communications to overcome traditional bandwidth limitations of electrical…

Nanofabrication techniques for achieving dimensional control at the nanometer scale are generally equipment-intensive and time-consuming. The use of energetic beams of electrons or ions has placed the fabrication of nanopores in thin…

Mesoscale and Nanoscale Physics · Physics 2014-03-25 Harold Kwok , Kyle Briggs , Vincent Tabard-Cossa

Large-scale neural recording with high spatio-temporal resolution is essential for understanding information processing in brain, yet current neural interfaces fall far short of comprehensively capturing brain activity due to extremely high…

High-speed signal processing is essential for maximizing data throughput in emerging communication applications, like multiple-input multiple-output (MIMO) systems and radio-frequency (RF) interference cancellation. However, as these…

Magnetic particle imaging (MPI) is an in-vivo imaging method to detect magnetic nanoparticles for blood vessel imaging and molecular target imaging. Compared with conventional molecular imaging devices (such as nuclear medicine imaging PET…

Medical Physics · Physics 2024-04-26 Guang Jia , Zhongwei Bian , Tianshu Li , Shi Bai , Chenxing Hu , Lixuan Zhao , Peng Gao , Tanping Li , Hui Hui , Jie Tian

Advanced neural interfaces mediate a bio-electronic link between the nervous system and microelectronic devices, bearing great potential as innovative therapy for various diseases. Spikes from a large number of neurons are recorded leading…

Emerging Technologies · Computer Science 2016-11-30 Isha Gupta , Alexantrou Serb , Ali Khiat , Ralf Zeitler , Stefano Vassanelli , Themistoklis Prodromakis

Multimode squeezed light is a key resource for high-dimensional quantum technologies, enhancing metrological sensitivity, boosting communication security, and enabling parallel processing in computation. Its practical potential, however,…

Quantum Physics · Physics 2025-10-09 Mahmoud Kalash , Aditya Sudharsanam , M. H. M. Passos , Valentina Parigi , Maria Chekhova

Abstract: Bionic learning with fused sensing, memory and processing functions outperforms artificial neural networks running on silicon chips in terms of efficiency and footprint. However, digital hardware implementation of bionic learning…

Emerging Technologies · Computer Science 2022-02-22 Shijie Wang , Xi Chen , Chao Zhao , Yuxin Kong , Baojun Lin , Yongyi Wu , Zhaozhao Bi , Ziyi Xuan , Tao Li , Yuxiang Li , Wei Zhang , En Ma , Zhongrui Wang , Wei Ma

Label-free biosensors are important tools for clinical diagnostics and for studying biology at the single molecule level. The development of optical label-free sensors has allowed extreme sensitivity, but can expose the biological sample to…

Surface Plasmon Resonance sensors are a well-established class of sensors which includes a very large variety of materials and detection schemes. However, the development of portable devices is still challenging as due to the intrinsic…