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Mesoporous silica nanoparticles (MSNPs) have many potential applications in biomedical fields. However, when MSNPs are exposed to plasma, protein adsorption leads to opsonization and decreases blood circulation time. A new multifunctional…

Tissues and Organs · Quantitative Biology 2021-05-24 Sandra Sanchez-Salcedo , Maria Vallet-Regi , Sophia Allaf Shanin , Carlotta A. Glackin , Jeffrey I. Zink

Fabricating brightly fluorescent layers with nanometric thickness and digitally controlled lateral structuration remains a challenge for next-generation photonic devices, optical calibration standards, and biocompatible interfaces. Here, we…

Neural network (NN) accelerators with multi-chip-module (MCM) architectures enable integration of massive computation capability; however, they face challenges of computing resource underutilization and off-chip communication overheads.…

Hardware Architecture · Computer Science 2026-02-17 Zongle Huang , Hongyang Jia , Kaiwei Zou , Yongpan Liu

Identification of vessel structures of different sizes in biomedical images is crucial in the diagnosis of many neurodegenerative diseases. However, the sparsity of good-quality annotations of such images makes the task of vessel…

Accurate detection and characterization of nanoparticles within confined spaces is crucial for applications ranging from nanofluidics to biotechnology. We present a novel approach that combines interferometric scattering (iSCAT) detection…

Our growing ability to tailor healthcare to the needs of individuals has the potential to transform clinical treatment. However, the measurement of multiple biomarkers to inform clinical decisions requires rapid, effective, and affordable…

To accomplish relatively complex tasks, in Internet of Bio-Nano Things (IoBNT), information collected by different nano-machines (NMs) is usually sent via multiple-access channels to fusion centers (FCs) for further processing. Relying on…

Information Theory · Computer Science 2024-02-27 Weidong Gao , Lu Shi , Lie-Liang Yang

Advances in chip-scale photonic-electronic integration are enabling a new generation of foundry-manufacturable implantable silicon neural probes incorporating nanophotonic waveguides and microelectrodes for optogenetic stimulation and…

Reliable hardware connectivity is vital in heterogeneous integrated systems. For example, in digital microfluidics lab-on-a-chip systems, there are hundreds of physical connections required between a micro-electro-mechanical fabricated…

Systems and Control · Electrical Eng. & Systems 2020-04-15 Chunjie Zhang , Yang Su , Siyi Hu , Kai Jin , Yuhan Jie , Wenshi Li , Arokia Nathan , Hanbin Ma

Onboard intelligent processing is widely applied in emergency tasks in the field of remote sensing. However, it is predominantly confined to an individual platform with a limited observation range as well as susceptibility to interference,…

Computer Vision and Pattern Recognition · Computer Science 2023-09-06 Zhechao Wang , Peirui Cheng , Shujing Duan , Kaiqiang Chen , Zhirui Wang , Xinming Li , Xian Sun

Time-of-flight measurements are key to study distributed mode coupling and differential mode group delay (DMDG) in multimode fibers (MMFs). However, current approaches using regular photodetectors with limited sensitivity preclude the…

Translocation event detection from raw nanopore current signals is a fundamental step in nanopore signal analysis. Traditional data analysis methods rely on user-defined parameters to extract event information, making the interpretation of…

Signal Processing · Electrical Eng. & Systems 2025-04-09 Jaise Johnson , Chinmayi R Galigekere , Manoj M Varma

The integration on a single chip of the sensitivity-relevant electronics of nuclear magnetic resonance (NMR) and electron spin resonance (ESR) spectrometers is a promising approach to improve the limit of detection, especially for samples…

Instrumentation and Detectors · Physics 2020-03-09 Nergiz Sahin Solmaz , Marco Grisi , Alessandro Valentino Matheoud , Gabriele Gualco , Giovanni Boero

Conventional spectrometer and polarimeter systems rely on bulky optics, fundamentally limiting compact integration and hindering multi-dimensional optical sensing capabilities. Here, we propose a spectropolarimeter enabled by…

Optics · Physics 2026-04-13 Jumin Qiu , Tingting Liu , Chenxuan Xiang , Tianbao Yu , Qiegen Liu , Shuyuan Xiao

The slowing down of Moore's law has driven the development of application-specific processors for deep learning. Analog photonic processors offer a promising solution for accelerating matrix-vector multiplications (MVMs) in deep learning by…

Optical biosensors are indispensable in medical and environmental diagnostics, yet existing approaches are fundamentally limited in their sensitivity due to ensemble-averaged measurements. Digital biosensing has emerged as a promising…

Integrated arrays of Superconducting Nanowire Single Photon Detectors (SNSPDs) have shown capabilities such as Photon Number Resolution, single photon imaging and coincidences detection, and can be effectively used also in other different…

A central goal in creating long-distance quantum networks and distributed quantum computing is the development of interconnected and individually controlled qubit nodes. Atom-like emitters in diamond have emerged as a leading system for…

In modern applications of heterogeneous liquid-phase nanocatalysis, the catalysts (e.g., metal nanoparticles) need to be typically affixed to a colloidal carrier system for stability and easy handling. "Passive carriers" (e.g., simple…

Chemical Physics · Physics 2020-03-23 Matej Kanduc , Won Kyu Kim , Rafael Roa , Joachim Dzubiella

Multifunctional nanomaterials combining diagnosis and therapeutic properties have attracted a considerable attention in cancer research. Yet some important challenges are still to be faced, including an optimal coupling between these two…

Biological Physics · Physics 2019-10-31 Yupeng Shi , Flavien Guenneau , Xiaolin Wang , Christophe Hélary , Thibaud Coradin