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Recent advances in technology have enabled the measurement of RNA levels for individual cells. Compared to traditional tissue-level bulk RNA-seq data, single cell sequencing yields valuable insights about gene expression profiles for…

Applications · Statistics 2019-04-16 Lingxue Zhu , Jing Lei , Bernie Devlin , Kathryn Roeder

This work studies the feasibility of applying quantum kernel methods to a real consumer classification task in the NISQ regime. We present a hybrid pipeline that combines a quantum-kernel Support Vector Machine (Q-SVM) with a quantum…

Quantum Physics · Physics 2026-03-04 Laura Sáez-Ortuño , Santiago Forgas-Coll , Massimiliano Ferrara

Single-cell RNA-Sequencing (scRNA-Seq) is a revolutionary technique for discovering and describing cell types in heterogeneous tissues, yet its measurement of expression often suffers from large systematic bias. A major source of this bias…

Quantitative Methods · Quantitative Biology 2016-05-17 Martin Barron , Jun Li

Quantum circuit simulation provides the foundation for the development of quantum algorithms and the verification of quantum supremacy. Among the various methods for quantum circuit simulation, tensor network contraction has been increasing…

Quantum Physics · Physics 2023-07-11 Hiroyuki Ootomo , Hidetaka Manabe , Kenji Harada , Rio Yokota

A promising platform for semi-device-independent quantum information is prepare-and-measure experiments restricted only by a bound on the energy of the communication. Here, we investigate the role of shared entanglement in such scenarios.…

Quantum Physics · Physics 2026-03-19 Carles Roch I Carceller , Armin Tavakoli

Single-cell RNA-seq foundation models achieve strong performance on downstream tasks but remain black boxes, limiting their utility for biological discovery. Recent work has shown that sparse dictionary learning can extract concepts from…

Genomics · Quantitative Biology 2025-10-31 Charlotte Claye , Pierre Marschall , Wassila Ouerdane , Céline Hudelot , Julien Duquesne

We investigate time-dependent data analysis from the perspective of recurrent kernel machines, from which models with hidden units and gated memory cells arise naturally. By considering dynamic gating of the memory cell, a model closely…

Machine Learning · Statistics 2019-10-11 Kevin J Liang , Guoyin Wang , Yitong Li , Ricardo Henao , Lawrence Carin

Single-cell RNA-seq data allow the quantification of cell type differences across a growing set of biological contexts. However, pinpointing a small subset of genomic features explaining this variability can be ill-defined and…

Machine Learning · Statistics 2022-07-29 Nabeel Sarwar , Wilson Gregory , George A Kevrekidis , Soledad Villar , Bianca Dumitrascu

Quantum collision models have proved to be useful for a clear and concise description of many physical phenomena in the field of open quantum systems: thermalization, decoherence, homogenization, nonequilibrium steady state, entanglement…

Quantum Physics · Physics 2022-04-06 Sergey N. Filippov

Stochastic models of reaction-diffusion systems are important for the study of biochemical reaction networks where species are present in low copy numbers or if reactions are highly diffusion limited. In living cells many such systems…

Numerical Analysis · Mathematics 2015-06-15 Stefan Hellander

Large language models (LLMs) have shown strong ability in generating rich representations across domains such as natural language processing and generation, computer vision, and multimodal learning. However, their application in biomedical…

Genomics · Quantitative Biology 2025-09-30 Luxuan Zhang , Douglas Jiang , Qinglong Wang , Haoqi Sun , Feng Tian

From the modern perspective of causal inference, Bell's theorem -- a fundamental signature of quantum theory -- is a particular case where quantum correlations are incompatible with the classical theory of causality, and the generalization…

Quantum Physics · Physics 2024-05-30 Pedro Lauand , Bereket Ngussie Bekele , Elie Wolfe

We introduce a quantum neural network, QNN, that can represent labeled data, classical or quantum, and be trained by supervised learning. The quantum circuit consists of a sequence of parameter dependent unitary transformations which acts…

Quantum Physics · Physics 2018-09-03 Edward Farhi , Hartmut Neven

Quantum information can not be perfectly cloned, but approximate copies of quantum information can be generated. Quantum telecloning combines approximate quantum cloning, more typically referred as quantum cloning, and quantum…

Quantum Physics · Physics 2024-05-09 Elijah Pelofske , Andreas Bärtschi , Stephan Eidenbenz , Bryan Garcia , Boris Kiefer

Benchmarking of quantum machine learning (QML) algorithms is challenging due to the complexity and variability of QML systems, e.g., regarding model ansatzes, data sets, training techniques, and hyper-parameters selection. The QUantum…

Difficult problems described in terms of interacting quantum fields evolving in real time or out of equilibrium are abound in condensed-matter and high-energy physics. Addressing such problems via controlled experiments in atomic,…

Quantum Physics · Physics 2017-10-23 A. Bermudez , G. Aarts , M. Müller

Classical simulations of quantum circuits play a vital role in the development of quantum computers and for taking the temperature of the field. Here, we classically simulate various physically-motivated circuits using 2D tensor network…

Quantum Physics · Physics 2025-09-16 Manuel S. Rudolph , Joseph Tindall

The use of kernel functions is a common technique to extract important features from data sets. A quantum computer can be used to estimate kernel entries as transition amplitudes of unitary circuits. Quantum kernels exist that, subject to…

Molecular biology explains function of molecules by their geometrical and electronical structures that are mainly determined by utilization of quantum effects in chemistry. However, further quantum effects are not thought to play any…

Quantum Physics · Physics 2011-12-30 Onur Pusuluk , Cemsinan Deliduman

We develop a simulator for quantum computers composed of superconducting transmon qubits. The simulation model supports an arbitrary number of transmons and resonators. Quantum gates are implemented by time-dependent pulses. Nontrivial…

Quantum Physics · Physics 2020-09-01 Dennis Willsch