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An important challenge in cancer systems biology is to uncover the complex network of interactions between genes (tumor suppressor genes and oncogenes) implicated in cancer. Next generation sequencing provides unparalleled ability to probe…

Genomics · Quantitative Biology 2012-12-10 Ying Cai , Bernard Fendler , Gurinder S. Atwal

Single-cell RNA-sequencing (scRNA-seq) stands as a powerful tool for deciphering cellular heterogeneity and exploring gene expression profiles at high resolution. However, its high cost renders it impractical for extensive sample cohorts…

Recent work has extended Bell's theorem by quantifying the amount of communication required to simulate entangled quantum systems with classical information. The general scenario is that a bipartite measurement is given from a set of…

Quantum Physics · Physics 2009-11-06 Serge Massar , Dave Bacon , Nicolas Cerf , Richard Cleve

As quantum computers become increasingly practical, so does the prospect of using quantum computation to improve upon traditional algorithms. Kernel methods in machine learning is one area where such improvements could be realized in the…

Quantum Physics · Physics 2023-05-30 Ara Ghukasyan , Jack S. Baker , Oktay Goktas , Juan Carrasquilla , Santosh Kumar Radha

Quantum Recurrent Neural Networks (QRNNs) are robust candidates for modelling and predicting future values in multivariate time series. However, the effective implementation of some QRNN models is limited by the need for mid-circuit…

Quantum Physics · Physics 2025-01-31 José Daniel Viqueira , Daniel Faílde , Mariamo M. Juane , Andrés Gómez , David Mera

As trapped-ion quantum computing scales to larger qubit registers and more complex control protocols, classical control systems face a fundamental tradeoff: sub-microsecond board-level feedback requires tight hardware coupling, whereas…

Quantum Physics · Physics 2026-05-22 Junpeng She , Ruoyu Yan , Zhizhen Qin , Zhanyu Li , Zhongtao Shen , Zichao Zhou , Binxiang Qi , Luming Duan

Simulation tasks are insightful tools to compare information-theoretic resources. Considering a generalization of usual Bell scenarios where external quantum inputs are provided to the parties, we show that any entangled quantum state…

Quantum Physics · Physics 2013-06-06 Denis Rosset , Cyril Branciard , Nicolas Gisin , Yeong-Cherng Liang

We present a new Hamiltonian-learning framework based on time-resolved measurement data from a fixed local IC-POVM and its application to inferring gene regulatory networks. We introduce the quantum Hamiltonian-based gene-expression model…

Quantum Physics · Physics 2026-02-24 Mohammad Aamir Sohail , Ranga R. Sudharshan , S. Sandeep Pradhan , Arvind Rao

Quantum neural networks (QNNs) represent a pioneering intersection of quantum computing and deep learning. In this study, we unveil a fundamental convolution property inherent to QNNs, stemming from the natural parallelism of quantum gate…

Quantum Physics · Physics 2025-04-14 Guangkai Qu , Zhimin Wang , Guoqiang Zhong , Yongjian Gu

We introduce the concept of 1Q, the first wireless generation of integrated classical and quantum communication. 1Q features quantum base stations (QBSs) that support entanglement distribution via free-space optical links alongside…

Gene regulatory networks (GRNs) represent the causal relationships between transcription factors (TFs) and target genes in single-cell RNA sequencing (scRNA-seq) data. Understanding these networks is crucial for uncovering disease…

Artificial Intelligence · Computer Science 2024-10-22 Tejumade Afonja , Ivaxi Sheth , Ruta Binkyte , Waqar Hanif , Thomas Ulas , Matthias Becker , Mario Fritz

Motivation: In a predictive modeling setting, if sufficient details of the system behavior are known, one can build and use a simulation for making predictions. When sufficient system details are not known, one typically turns to machine…

Machine Learning · Statistics 2019-08-14 Timo M. Deist , Andrew Patti , Zhaoqi Wang , David Krane , Taylor Sorenson , David Craft

Modeling complex semiconductor fabrication processes such as Ohmic contact formation remains challenging due to high-dimensional parameter spaces and limited experimental data. While classical machine learning (CML) approaches have been…

Machine Learning · Computer Science 2025-06-26 Zeheng Wang , Fangzhou Wang , Liang Li , Zirui Wang , Timothy van der Laan , Ross C. C. Leon , Jing-Kai Huang , Muhammad Usman

Single-Cell RNA sequencing (scRNA-seq) measurements have facilitated genome-scale transcriptomic profiling of individual cells, with the hope of deconvolving cellular dynamic changes in corresponding cell sub-populations to better…

Genomics · Quantitative Biology 2021-04-06 Seyednami Niyakan , Ehsan Hajiramezanali , Shahin Boluki , Siamak Zamani Dadaneh , Xiaoning Qian

Quantum natural language processing (QNLP) offers a novel approach to semantic modeling by embedding compositional structure directly into quantum circuits. This paper investigates the application of QNLP models to the task of Natural…

Computation and Language · Computer Science 2025-10-21 Ling Sun , Peter Sullivan , Michael Martin , Yun Zhou

Single-cell transcriptomics techniques, such as scRNA-seq, attempt to characterize gene expression profiles in each cell of a heterogeneous sample individually. Due to growing amounts of data generated and the increasing complexity of the…

Genomics · Quantitative Biology 2023-05-02 Laura Puente-Santamaría , Luis del Peso

Time-series single-cell RNA-sequencing (scRNA-seq) datasets offer unprecedented insights into the dynamics and heterogeneity of cellular systems. These systems exhibit multiscale collective behaviors driven by intricate intracellular gene…

Quantitative Methods · Quantitative Biology 2025-05-23 Qi Jiang , Lei Zhang , Longquan Li , Lin Wan

A simple protocol which takes advantage of the inherent random times of detections in single photon counting modules is presented for random active basis choices when using entanglement-based protocols for Quantum Key Distribution (QKD). It…

Quantum effects are mainly used for the determination of molecular shapes in molecular biology, but quantum information theory may be a more useful tool to understand the physics of life. Organic molecules and quantum circuits/protocols can…

Quantum Physics · Physics 2011-04-01 Onur Pusuluk , Cemsinan Deliduman

Similar to the classical Internet, the quantum Internet will require knowledge regarding link qualities used for purposes such as optimal route selection. This is commonly accomplished by performing link-level tomography with or without…

Quantum Physics · Physics 2019-08-30 Takaaki Matsuo