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Quantum one-class support vector machines leverage the advantage of quantum kernel methods for semi-supervised anomaly detection. However, their quadratic time complexity with respect to data size poses challenges when dealing with large…

Single-cell RNA sequencing (scRNA-seq) has revealed complex cellular heterogeneity, but recent studies emphasize that understanding biological function also requires modeling cell-cell communication (CCC), the signaling interactions…

Machine Learning · Computer Science 2025-12-29 Cong Qi , Yeqing Chen , Zhi Wei

The exploration of cellular heterogeneity within the tumor microenvironment (TME) via single-cell RNA sequencing (scRNA-seq) is essential for understanding cancer progression and response to therapy. Current scRNA-seq approaches, however,…

Genomics · Quantitative Biology 2025-02-06 Yu-An Huang , Yue-Chao Li , Hai-Ru You , Jie Pan , Xiyue Cao , Xinyuan Li , Zhi-An Huang , Zhu-Hong You

The Quantum Internet would likely be composed of diverse qubit technologies that interact through a heterogeneous quantum network. Thus, quantum transduction has been identified as a key enabler of the Quantum Internet. To better study…

The cell cycle is one of the most fundamental biological processes important for understanding normal physiology and various pathologies such as cancer. Single cell RNA sequencing technologies give an opportunity to analyse the cell cycle…

Quantitative Methods · Quantitative Biology 2022-08-11 Alexander Chervov , Andrei Zinovyev

We develop and implement two realizations of quantum graph neural networks (QGNN), applied to the task of particle interaction simulation. The first QGNN is a speculative quantum-classical hybrid learning model that relies on the ability to…

Kernel methods are used extensively in classical machine learning, especially in the field of pattern analysis. In this paper, we propose a kernel-based quantum machine learning algorithm that can be implemented on a near-term, intermediate…

Quantum Physics · Physics 2019-06-11 Roohollah Ghobadi , Jaspreet S. Oberoi , Ehsan Zahedinejhad

RNA sequencing techniques, like bulk RNA-seq and Single Cell (sc) RNA-seq, are critical tools for the biologist looking to analyze the genetic activity/transcriptome of a tissue or cell during an experimental procedure. Platforms like…

Genomics · Quantitative Biology 2024-07-08 Devam Mondal , Atharva Inamdar

The swift advancement of single-cell RNA sequencing (scRNA-seq) technologies enables the investigation of cellular-level tissue heterogeneity. Cell annotation significantly contributes to the extensive downstream analysis of scRNA-seq data.…

Machine Learning · Computer Science 2024-11-28 Huifa Li , Jie Fu , Xinpeng Ling , Zhiyu Sun , Kuncan Wang , Zhili Chen

Applications of single-cell RNA sequencing in various biomedical research areas have been blooming. This new technology provides unprecedented opportunities to study disease heterogeneity at the cellular level. However, unique…

Genomics · Quantitative Biology 2021-10-26 Xinlei Mi , William Bekerman , Peter A. Sims , Peter D. Canoll , Jianhua Hu

Recent experimental advances in biology allow researchers to obtain gene expression profiles at single-cell resolution over hundreds, or even thousands of cells at once. These single-cell measurements provide snapshots of the states of the…

Computational Engineering, Finance, and Science · Computer Science 2018-01-18 Jasmin Fisher , Ali Sinan Köksal , Nir Piterman , Steven Woodhouse

Simulating quantum physical processes has been one of the major motivations for quantum information science. Quantum channels, which are completely positive and trace preserving processes, are the standard mathematical language to describe…

Quantum Physics · Physics 2024-02-01 Hang Li , Kai Wang , Shijie Wei , Fan Yang , Xinyu Chen , Barry C. Sanders , Dong-Sheng Wang , Gui-Lu Long

Modeling cellular dynamics from single-cell RNA sequencing (scRNA-seq) data is critical for understanding cell development and underlying gene regulatory relationships. Many current methods rely on single-cell velocity to obtain pseudotime,…

Molecular Networks · Quantitative Biology 2024-10-25 Zhen Zhou , Jiachen Li , Hongyi Xin , Xiaoyong Pan , Hong-Bin Shen

Quantum entanglement is a key ingredient for quantum information processing with capabilities beyond that of classical computation. We study the generation and role of entanglement in the dynamics of spin-1/2 models, both for the design of…

Quantum Physics · Physics 2024-06-11 Anupam Mitra

Quantum communication networks (QCNs) utilize quantum mechanics for secure information transmission, but the reliance on fragile and expensive photonic quantum resources renders QCN resource optimization challenging. Unlike prior QCN works…

Networking and Internet Architecture · Computer Science 2024-04-30 Mahdi Chehimi , Christina Chaccour , Christo Kurisummoottil Thomas , Walid Saad

Modeling cellular states and predicting their responses to perturbations are central challenges in computational biology and the development of virtual cells. Existing foundation models for single-cell transcriptomics provide powerful…

Quantitative Methods · Quantitative Biology 2026-03-31 Han Zhang , Guo-Hua Yuan , Chaohao Yuan , Tingyang Xu , Tian Bian , Hong Cheng , Wenbing Huang , Deli Zhao , Yu Rong

Quantum network simulators offer the opportunity to cost-efficiently investigate potential avenues to building networks that scale with the number of users, communication distance, and application demands by simulating alternative hardware…

Quantum Physics · Physics 2024-08-13 Xiaoliang Wu , Alexander Kolar , Joaquin Chung , Dong Jin , Rajkumar Kettimuthu , Martin Suchara

Generative modeling using samples drawn from the probability distribution constitutes a powerful approach for unsupervised machine learning. Quantum mechanical systems can produce probability distributions that exhibit quantum correlations…

Quantum Physics · Physics 2022-10-07 Xun Gao , Eric R. Anschuetz , Sheng-Tao Wang , J. Ignacio Cirac , Mikhail D. Lukin

A discrete-event approach, which has already been shown to give a cause-and-effect explanation of many quantum optics experiments, is applied to single-neutron interferometry experiments. The simulation algorithm yields a logically…

Quantum Physics · Physics 2015-06-11 Hans De Raedt , Fengping Jin , Kristel Michielsen

The simple genetic algorithm is proposed for the simulation of quantum many body dynamics. It uses the selection of entangled quantum states and has the inbuilt absolute decoherence that comes from the limitation of classical memory. It…

Quantum Physics · Physics 2008-01-24 Yuri Ozhigov
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