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Quantum Machine Learning (QML) has emerged as a promising framework for exploring how quantum dynamics may enhance data processing tasks. Here we investigate Quantum Extreme Learning Machines (QELMs), a quantum analogue of classical Extreme…

Quantum Physics · Physics 2026-04-27 A. De Lorenzis , M. P. Casado , N. Lo Gullo , T. Lux , F. Plastina , A. Riera

Quantum networks are expected to become a key enabler for interconnecting quantum devices. In contrast to classical communication networks, however, information transfer in quantum networks is usually restricted to short distances due to…

Quantum Physics · Physics 2026-04-13 Tobias Meuser , Jannis Weil , Aninda Lahiri , Marius Paraschiv

The data encoding circuits used in quantum support vector machine (QSVM) kernels play a crucial role in their classification accuracy. However, manually designing these circuits poses significant challenges in terms of time and performance.…

Quantum Physics · Physics 2026-05-22 Floyd M. Creevey , Jamie A. Heredge , Martin E. Sevior , Lloyd C. L. Hollenberg

Single-cell RNA sequencing (scRNA-seq) offers detailed insights into cellular heterogeneity. Recent advancements leverage single-cell large language models (scLLMs) for effective representation learning. These models focus exclusively on…

Machine Learning · Computer Science 2025-06-05 Yaorui Shi , Jiaqi Yang , Changhao Nai , Sihang Li , Junfeng Fang , Xiang Wang , Zhiyuan Liu , Yang Zhang

Single-cell RNA sequencing (scRNA-seq) data exhibit strong and reproducible statistical structure. This has motivated the development of large-scale foundation models, such as TranscriptFormer, that use transformer-based architectures to…

Genomics · Quantitative Biology 2026-02-19 Huan Souza , Pankaj Mehta

Feature selection is a machine learning technique for identifying relevant variables in classification and regression models. In single-cell RNA sequencing (scRNA-seq) data analysis, feature selection is used to identify relevant genes that…

Genomics · Quantitative Biology 2025-12-02 Selim Romero , Shreyan Gupta , Victoria Gatlin , Robert S. Chapkin , James J. Cai

Single-cell RNA sequencing (scRNA-seq), especially temporally resolved datasets, enables genome-wide profiling of gene expression dynamics at single-cell resolution across discrete time points. However, current technologies provide only…

Genomics · Quantitative Biology 2025-11-19 Yue Ling , Peiqi Zhang , Zhenyi Zhang , Peijie Zhou

Single-cell RNA sequencing (scRNA-seq) enables single-cell transcriptomic profiling, revealing cellular heterogeneity and rare populations. Recent deep learning models like Geneformer and Mouse-Geneformer perform well on tasks such as…

Genomics · Quantitative Biology 2025-07-11 Yuki Nishio , Takayoshi Yamashita , Keita Ito , Tsubasa Hirakawa , Hironobu Fujiyoshi

RNA sequencing (RNA-seq) is the conventional genome-scale approach used to capture the expression levels of all detectable genes in a biological sample. This is now regularly used for population-based studies designed to identify genetic…

Genomics · Quantitative Biology 2026-05-25 Christopher Thron , Farhad Jafari

Many modern biological assays, including RNA sequencing, yield integer-valued counts that reflect the number of molecules detected. These measurements are often not at the desired resolution: while the unit of interest is typically a single…

Machine Learning · Computer Science 2026-03-06 Nic Fishman , Gokul Gowri , Tanush Kumar , Jiaqi Lu , Valentin de Bortoli , Jonathan S. Gootenberg , Omar Abudayyeh

Single-cell RNA sequencing (scRNA-seq) enables high-resolution analysis of cellular heterogeneity, but its complexity, which is marked by high dimensionality, sparsity, and batch effects, which poses major computational challenges.…

Computation and Language · Computer Science 2026-03-25 Cong Qi , Hanzhang Fang , Siqi Jiang , Xun Song , Tianxing Hu , Wei Zhi

Single-cell RNA-seq datasets are growing in size and complexity, enabling the study of cellular composition changes in various biological/clinical contexts. Scalable dimensionality reduction techniques are in need to disentangle biological…

Establishing end-to-end quantum connections requires quantified link characteristics, and operations need to coordinate decision-making between nodes across a network. We introduce the RuleSet-based communication protocol for supporting…

Quantum Physics · Physics 2019-11-20 Takaaki Matsuo , Clément Durand , Rodney Van Meter

Single-cell RNA sequencing (scRNA-seq) has revolutionized the study of cellular heterogeneity, enabling detailed molecular profiling at the individual cell level. However, integrating high-dimensional single-cell data into causal mediation…

Methodology · Statistics 2025-10-01 Seungjun Ahn , Li Chen , Maaike van Gerwen , Panos Roussos , Zhigang Li

In quantum kernel learning, the primary method involves using a quantum computer to calculate the inner product between feature vectors, thereby obtaining a Gram matrix used as a kernel in machine learning models such as support vector…

Quantum Physics · Physics 2024-05-17 Hiroshi Yamauchi , Tomah Sogabe , Rodney Van Meter

Structural equation models (SEMs) have been widely adopted for inference of causal interactions in complex networks. Recent examples include unveiling topologies of hidden causal networks over which processes such as spreading diseases, or…

Machine Learning · Statistics 2017-04-05 Yanning Shen , Brian Baingana , Georgios B. Giannakis

The incorporation of quantum ansatz with machine learning classification models demonstrates the ability to extract patterns from data for classification tasks. However, taking advantage of the enhanced computational power of quantum…

Quantum Physics · Physics 2024-11-13 Arpita Ghosh , MD Muhtasim Fuad , Seemanta Bhattacharjee

Knowing gene regulatory networks (GRNs) is important for understanding various biological mechanisms. In this paper, we present a method, QWENDY, that uses single-cell gene expression data measured at four time points to infer GRNs. Based…

Molecular Networks · Quantitative Biology 2025-09-30 Yue Wang , Xueying Tian

Hybrid quantum-classical models represent a crucial step toward leveraging near-term quantum devices for sequential data processing. We present Quantum Recurrent Neural Networks (QRNNs) and Quantum Convolutional Neural Networks (QCNNs) as…

Quantum Physics · Physics 2025-12-16 Stefan Balauca , Ada-Astrid Balauca , Adrian Iftene

Dynamical quantum phase transition is a critical phenomenon involving out-of-equilibrium states and broken symmetries without classical analogy. However, when finite-sized systems are analyzed, dynamical singularities of the rate function…

Quantum Physics · Physics 2024-05-28 Diego Tancara , José Fredes , Ariel Norambuena