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A visual-language model (VLM) pre-trained on natural images and text pairs poses a significant barrier when applied to medical contexts due to domain shift. Yet, adapting or fine-tuning these VLMs for medical use presents considerable…

Computer Vision and Pattern Recognition · Computer Science 2024-05-31 Aisha Urooj Khan , John Garrett , Tyler Bradshaw , Lonie Salkowski , Jiwoong Jason Jeong , Amara Tariq , Imon Banerjee

Biomedical semantic question answering rooted in information retrieval can play a crucial role in keeping up to date with vast, rapidly evolving and ever-growing biomedical literature. A robust system can help researchers, healthcare…

Information Retrieval · Computer Science 2025-07-09 Shashank Verma , Fengyi Jiang , Xiangning Xue

Large Language Models (LLMs) show promise in biomedicine but lack true causal understanding, relying instead on correlations. This paper envisions causal LLM agents that integrate multimodal data (text, images, genomics, etc.) and perform…

Artificial Intelligence · Computer Science 2025-05-23 Adib Bazgir , Amir Habibdoust Lafmajani , Yuwen Zhang

Language Models (LMs) have performed well on biomedical natural language processing applications. In this study, we conducted some experiments to use prompt methods to extract knowledge from LMs as new knowledge Bases (LMs as KBs). However,…

Information Retrieval · Computer Science 2022-10-24 Zonghai Yao , Yi Cao , Zhichao Yang , Vijeta Deshpande , Hong Yu

The rapid expansion of publicly-available medical data presents a challenge for clinicians and researchers alike, increasing the gap between the volume of scientific literature and its applications. The steady growth of studies and findings…

Artificial Intelligence · Computer Science 2025-08-06 Taine J. Elliott , Stephen P. Levitt , Ken Nixon , Martin Bekker

Knowledge graphs have emerged as a popular method for injecting up-to-date, factual knowledge into large language models (LLMs). This is typically achieved by converting the knowledge graph into text that the LLM can process in context.…

Computation and Language · Computer Science 2025-04-10 Elan Markowitz , Krupa Galiya , Greg Ver Steeg , Aram Galstyan

Pre-training large-scale neural language models on raw texts has made a significant contribution to improving transfer learning in natural language processing (NLP). With the introduction of transformer-based language models, such as…

Computation and Language · Computer Science 2024-05-08 Shoya Wada , Toshihiro Takeda , Shiro Manabe , Shozo Konishi , Jun Kamohara , Yasushi Matsumura

We study the adaptation of Link Grammar Parser to the biomedical sublanguage with a focus on domain terms not found in a general parser lexicon. Using two biomedical corpora, we implement and evaluate three approaches to addressing unknown…

Computation and Language · Computer Science 2007-05-23 Sampo Pyysalo , Tapio Salakoski , Sophie Aubin , Adeline Nazarenko

Recent advances in Large Language Models (LLMs) have positioned them as a prominent solution for Natural Language Processing tasks. Notably, they can approach these problems in a zero or few-shot manner, thereby eliminating the need for…

Machine Learning · Computer Science 2025-05-07 Gerard Pons , Besim Bilalli , Anna Queralt

Foundation models (FMs) are able to leverage large volumes of unlabeled data to demonstrate superior performance across a wide range of tasks. However, FMs developed for biomedical domains have largely remained unimodal, i.e., independently…

Contextualized word embeddings derived from pre-trained language models (LMs) show significant improvements on downstream NLP tasks. Pre-training on domain-specific corpora, such as biomedical articles, further improves their performance.…

Computation and Language · Computer Science 2019-04-05 Qiao Jin , Bhuwan Dhingra , William W. Cohen , Xinghua Lu

Pre-trained language models (PLMs), such as BERT and GPT, have revolutionized the field of NLP, not only in the general domain but also in the biomedical domain. Most prior efforts in building biomedical PLMs have resorted simply to domain…

Computation and Language · Computer Science 2022-03-03 Quan Wang , Songtai Dai , Benfeng Xu , Yajuan Lyu , Yong Zhu , Hua Wu , Haifeng Wang

Currently, the main approach for Large Language Models (LLMs) to tackle the hallucination issue is incorporating Knowledge Graphs(KGs).However, LLMs typically treat KGs as plain text, extracting only semantic information and limiting their…

Computation and Language · Computer Science 2025-09-29 Yifang Zhang , Pengfei Duan , Yiwen Yang , Shengwu Xiong

Large language models like GPT-4, Gemini, and Claude have transformed natural language processing (NLP) tasks such as question answering, dialogue generation, summarization, and so forth; yet their susceptibility to hallucination stands as…

Computation and Language · Computer Science 2025-07-21 Nur A Zarin Nishat , Andrea Coletta , Luigi Bellomarini , Kossi Amouzouvi , Jens Lehmann , Sahar Vahdati

Recent proprietary large language models (LLMs), such as GPT-4, have achieved a milestone in tackling diverse challenges in the biomedical domain, ranging from multiple-choice questions to long-form generations. To address challenges that…

Computation and Language · Computer Science 2024-06-19 Minbyul Jeong , Jiwoong Sohn , Mujeen Sung , Jaewoo Kang

The biomedical domain has sparked a significant interest in the field of Natural Language Processing (NLP), which has seen substantial advancements with pre-trained language models (PLMs). However, comparing these models has proven…

Causal discovery aims to estimate causal structures among variables based on observational data. Large Language Models (LLMs) offer a fresh perspective to tackle the causal discovery problem by reasoning on the metadata associated with…

Computation and Language · Computer Science 2024-07-31 Yuni Susanti , Michael Färber

Recently, large language model (LLM) based artificial intelligence (AI) systems have demonstrated remarkable capabilities in natural language understanding and generation. However, these models face a significant challenge when it comes to…

Clinical antimicrobial therapy requires the dynamic integration of pathogen profiles,host factors, pharmacological properties of antimicrobials,and the severity of infection. This complexity imposes fundamental limitations on the…

Artificial Intelligence · Computer Science 2025-11-27 Zhe Li , Yehan Qiu , Yujie Chen , Xiang Zhou

Multilingual knowledge graph (KG) embeddings provide latent semantic representations of entities and structured knowledge with cross-lingual inferences, which benefit various knowledge-driven cross-lingual NLP tasks. However, precisely…

Artificial Intelligence · Computer Science 2018-06-19 Muhao Chen , Yingtao Tian , Kai-Wei Chang , Steven Skiena , Carlo Zaniolo