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Making histopathology image classifiers robust to a wide range of real-world variability is a challenging task. Here, we describe a candidate deep learning solution for the Mitosis Domain Generalization Challenge 2022 (MIDOG) to address the…

Image and Video Processing · Electrical Eng. & Systems 2023-01-04 Maxime W. Lafarge , Viktor H. Koelzer

Automatic skin lesion classification from dermoscopy images is important for the early diagnosis of skin diseases such as melanoma. Class imbalance in skin lesion datasets, notably the defects in the representation of malignant(cancerous)…

Quantitative Methods · Quantitative Biology 2025-12-19 Ariful Islam Khandaker , Abdullah Al Shafi , Mohiuddin Ahmad

The density of mitotic figures within tumor tissue is known to be highly correlated with tumor proliferation and thus is an important marker in tumor grading. Recognition of mitotic figures by pathologists is known to be subject to a strong…

Assessing the Mitotic Count has a known high degree of intra- and inter-rater variability. Computer-aided systems have proven to decrease this variability and reduce labeling time. These systems, however, are generally highly dependent on…

Image and Video Processing · Electrical Eng. & Systems 2022-03-16 Frauke Wilm , Christian Marzahl , Katharina Breininger , Marc Aubreville

We present a novel approach which extends the existing Fully Convolutional One-Stage Object Detector (FCOS) for mitotic figure detection. Our composite model adds a Feedback Attention Ladder CNN (FAL-CNN) model for classification of normal…

Image and Video Processing · Electrical Eng. & Systems 2025-09-22 Andrew Broad , Jason Keighley , Lucy Godson , Alex Wright

Accurate and robust medical image classification is a challenging task, especially in application domains where available annotated datasets are small and present high imbalance between target classes. Considering that data acquisition is…

Computer Vision and Pattern Recognition · Computer Science 2024-10-02 Neil De La Fuente , Mireia Majó , Irina Luzko , Henry Córdova , Gloria Fernández-Esparrach , Jorge Bernal

Biomedical datasets are often constrained by stringent privacy requirements and frequently suffer from severe class imbalance. These two aspects hinder the development of accurate machine learning models. While generative AI offers a…

Computer Vision and Pattern Recognition · Computer Science 2025-09-03 Jan Carreras Boada , Rao Muhammad Umer , Carsten Marr

The reliable identification of mitotic figures in whole-slide histopathological images remains difficult, owing to their low prevalence, substantial morphological heterogeneity, and the inconsistencies introduced by tissue processing and…

Image and Video Processing · Electrical Eng. & Systems 2025-09-23 Navya Sri Kelam , Akash Parekh , Saikiran Bonthu , Nitin Singhal

With a continuously growing availability of annotated datasets of mitotic figures in histology images, finding the best way to optimally use with this unprecedented amount of data to optimally train deep learning models has become a new…

Image and Video Processing · Electrical Eng. & Systems 2025-09-04 Maxime W. Lafarge , Viktor H. Koelzer

We present a solution for the MIDOG 2025 Challenge Track~2, addressing binary classification of normal mitotic figures (NMFs) versus atypical mitotic figures (AMFs). The approach leverages pathology-specific foundation model H-optimus-0,…

Breast cancer is the most commonly diagnosed cancer worldwide, with over two million new cases each year. During diagnostic tumour grading, pathologists manually count the number of dividing cells (mitotic figures) in biopsy or tumour…

Image and Video Processing · Electrical Eng. & Systems 2022-01-19 Jack Breen , Kieran Zucker , Nicolas M. Orsi , Nishant Ravikumar

We focus on the real-world problem of training accurate deep models for image classification of a small number of rare categories. In these scenarios, almost all images belong to the background category in the dataset (>95% of the dataset…

Computer Vision and Pattern Recognition · Computer Science 2020-09-01 Ravi Teja Mullapudi , Fait Poms , William R. Mark , Deva Ramanan , Kayvon Fatahalian

Counting of mitotic figures is a fundamental step in grading and prognostication of several cancers. However, manual mitosis counting is tedious and time-consuming. In addition, variation in the appearance of mitotic figures causes a high…

Computer Vision and Pattern Recognition · Computer Science 2023-09-26 Mostafa Jahanifar , Adam Shephard , Neda Zamanitajeddin , Simon Graham , Shan E Ahmed Raza , Fayyaz Minhas , Nasir Rajpoot

Recognition of mitotic figures in histologic tumor specimens is highly relevant to patient outcome assessment. This task is challenging for algorithms and human experts alike, with deterioration of algorithmic performance under shifts in…

This abstract presents our solution (Team Westwood) for mitosis detection and atypical mitosis classification in the MItosis DOmain Generalization (MIDOG) 2025 challenge. For mitosis detection, we trained an nnUNetV2 for initial mitosis…

Image and Video Processing · Electrical Eng. & Systems 2025-12-19 Tengyou Xu , Haochen Yang , Xiang 'Anthony' Chen , Hongyan Gu , Mohammad Haeri

Mitotic activity is key for the assessment of malignancy in many tumors. Moreover, it has been demonstrated that the proportion of abnormal mitosis to normal mitosis is of prognostic significance. Atypical mitotic figures (MF) can be…

Computer Vision and Pattern Recognition · Computer Science 2022-12-13 Marc Aubreville , Jonathan Ganz , Jonas Ammeling , Taryn A. Donovan , Rutger H. J. Fick , Katharina Breininger , Christof A. Bertram

Mitotic figure detection in histopathology images remains challenging due to significant domain shifts across different scanners, staining protocols, and tissue types. This paper presents our approach for the MIDOG 2025 challenge Track 1,…

Mitotic figure detection is a challenging task in digital pathology that has a direct impact on therapeutic decisions. While automated methods often achieve acceptable results under laboratory conditions, they frequently fail in the…

Image and Video Processing · Electrical Eng. & Systems 2022-01-21 Jakob Dexl , Michaela Benz , Volker Bruns , Petr Kuritcyn , Thomas Wittenberg

Small, imbalanced datasets and poor input image quality can lead to high false predictions rates with deep learning models. This paper introduces Class-Based Image Composition, an approach that allows us to reformulate training inputs…

Computer Vision and Pattern Recognition · Computer Science 2025-11-10 Hlali Azzeddine , Majid Ben Yakhlef , Soulaiman El Hazzat

The account of mitotic cells is a key feature in tumor diagnosis. However, due to the variability of mitotic cell morphology, it is a highly challenging task to detect mitotic cells in tumor tissues. At the same time, although advanced deep…

Computer Vision and Pattern Recognition · Computer Science 2022-08-29 Chen Yang , Wang Ziyue , Fang Zijie , Bian Hao , Zhang Yongbing