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Training a classification model on a dataset where the instances of one class outnumber those of the other class is a challenging problem. Such imbalanced datasets are standard in real-world situations such as fraud detection, medical…

Machine Learning · Computer Science 2020-09-04 Anubha Kabra , Ayush Chopra , Nikaash Puri , Pinkesh Badjatiya , Sukriti Verma , Piyush Gupta , Balaji K

I.I.D. hypothesis between training and testing data is the basis of numerous image classification methods. Such property can hardly be guaranteed in practice where the Non-IIDness is common, causing instable performances of these models. In…

Computer Vision and Pattern Recognition · Computer Science 2019-08-15 Yue He , Zheyan Shen , Peng Cui

Mitotic figures are classified into typical and atypical variants, with atypical counts correlating strongly with tumor aggressiveness. Accurate differentiation is therefore essential for patient prognostication and resource allocation, yet…

Image and Video Processing · Electrical Eng. & Systems 2025-09-19 Mieko Ochi , Bae Yuan

The effective localization of mitosis is a critical precursory task for deciding tumor prognosis and grade. Automated mitosis detection through deep learning-oriented image analysis often fails on unseen patient data due to inherent domain…

Computer Vision and Pattern Recognition · Computer Science 2022-09-20 Tirupati Saketh Chandr , Sahar Almahfouz Nasser , Nikhil Cherian Kurian , Amit Sethi

Imbalanced Data (ID) is a problem that deters Machine Learning (ML) models for achieving satisfactory results. ID is the occurrence of a situation where the quantity of the samples belonging to one class outnumbers that of the other by a…

Imbalanced classification often causes standard training procedures to prioritize the majority class and perform poorly on rare but important cases. A classic and widely used remedy is to augment the minority class with synthetic samples,…

Machine Learning · Statistics 2026-03-10 Zhengchi Ma , Anru R. Zhang

Synthetic image generation has opened up new opportunities but has also created threats in regard to privacy, authenticity, and security. Detecting fake images is of paramount importance to prevent illegal activities, and previous research…

Computer Vision and Pattern Recognition · Computer Science 2023-02-27 Md Awsafur Rahman , Bishmoy Paul , Najibul Haque Sarker , Zaber Ibn Abdul Hakim , Shaikh Anowarul Fattah

MIDOG 2025 Track 1 requires mitosis detection in whole-slideimages (WSIs) containing non-tumor, inflamed, and necrotic re-gions. Due to the complicated and heterogeneous context, aswell as possible artifacts, there are often false positives…

Image and Video Processing · Electrical Eng. & Systems 2025-09-29 Jie Xiao , Mengye Lyu , Shaojun Liu

Generative augmentation is often proposed as a remedy for small medical-image datasets, but synthetic images are only useful when they improve downstream task performance. "Augmentation" here means synthetic supplementation: GAN-generated…

Image and Video Processing · Electrical Eng. & Systems 2026-05-25 José Rafael Noriega Cedeño

This paper describes our contribution to the MIDOG 2022 challenge for detecting mitotic cells. One of the major problems to be addressed in the MIDOG 2022 challenge is the robustness under the natural variance that appears for real-life…

Computer Vision and Pattern Recognition · Computer Science 2023-09-14 Jonas Annuscheit , Christian Krumnow

Histopathological analysis is the present gold standard for precancerous lesion diagnosis. The goal of automated histopathological classification from digital images requires supervised training, which requires a large number of expert…

Image and Video Processing · Electrical Eng. & Systems 2021-11-15 Yuan Xue , Jiarong Ye , Qianying Zhou , Rodney Long , Sameer Antani , Zhiyun Xue , Carl Cornwell , Richard Zaino , Keith Cheng , Xiaolei Huang

This paper introduces MixDiff, a new self-supervised learning (SSL) pre-training framework that combines real and synthetic images. Unlike traditional SSL methods that predominantly use real images, MixDiff uses a variant of Stable…

Computer Vision and Pattern Recognition · Computer Science 2024-12-06 Reza Akbarian Bafghi , Nidhin Harilal , Claire Monteleoni , Maziar Raissi

Deep models, such as convolutional neural networks (CNNs) and vision transformer (ViT), demonstrate remarkable performance in image classification. However, those deep models require large data to fine-tune, which is impractical in the…

Computer Vision and Pattern Recognition · Computer Science 2025-05-30 Yihang Wu , Muhammad Owais , Reem Kateb , Ahmad Chaddad

Object detection, a pivotal task in computer vision, is frequently hindered by dataset imbalances, particularly the under-explored issue of foreground-foreground class imbalance. This lack of attention to foreground-foreground class…

Computer Vision and Pattern Recognition · Computer Science 2024-03-13 Nieves Crasto

Mitotic figure (MF) detection in histopathology images is challenging due to large variations in slide scanners, staining protocols, tissue types, and the presence of artifacts. This paper presents a collection of training techniques - a…

Computer Vision and Pattern Recognition · Computer Science 2025-08-28 Christian Marzahl , Brian Napora

The integration of deep learning based systems in clinical practice is often impeded by challenges rooted in limited and heterogeneous medical datasets. In addition, the field has increasingly prioritized marginal performance gains on a…

Image and Video Processing · Electrical Eng. & Systems 2025-03-18 Sebastian Doerrich , Francesco Di Salvo , Julius Brockmann , Christian Ledig

Pathologist-defined labels are the gold standard for histopathological data sets, regardless of well-known limitations in consistency for some tasks. To date, some datasets on mitotic figures are available and were used for development of…

Computer Vision and Pattern Recognition · Computer Science 2020-10-22 Christof A. Bertram , Mitko Veta , Christian Marzahl , Nikolas Stathonikos , Andreas Maier , Robert Klopfleisch , Marc Aubreville

Digital Breast Tomosynthesis (DBT) is a widely used medical imaging modality for breast cancer screening and diagnosis, offering higher spatial resolution and greater detail through its 3D-like breast volume imaging capability. However, the…

Image and Video Processing · Electrical Eng. & Systems 2024-03-21 Yuexi Du , Regina J. Hooley , John Lewin , Nicha C. Dvornek

Machine learning classifiers often stumble over imbalanced datasets where classes are not equally represented. This inherent bias towards the majority class may result in low accuracy in labeling minority class. Imbalanced learning is…

Machine Learning · Computer Science 2019-11-14 Wenhao Zhang , Ramin Ramezani , Arash Naeim

The development of multi-label deep learning models for retinal disease classification is often hindered by the scarcity of large, expertly annotated clinical datasets due to patient privacy concerns and high costs. The recent release of…

Computer Vision and Pattern Recognition · Computer Science 2025-08-25 Jerry Cao-Xue , Tien Comlekoglu , Keyi Xue , Guanliang Wang , Jiang Li , Gordon Laurie