English
Related papers

Related papers: Sparse Autoencoders for Low-$N$ Protein Function P…

200 papers

The mechanisms behind multilingual capabilities in Large Language Models (LLMs) have been examined using neuron-based or internal-activation-based methods. However, these methods often face challenges such as superposition and layer-wise…

Computation and Language · Computer Science 2025-05-28 Boyi Deng , Yu Wan , Yidan Zhang , Baosong Yang , Fuli Feng

Sparse autoencoders (SAEs) decompose language model representations into a sparse set of linear latent vectors. Recent works have improved SAEs using language model gradients, but these techniques require many expensive backward passes…

Machine Learning · Computer Science 2025-05-28 Matthew Chen , Joshua Engels , Max Tegmark

Unsupervised approaches to large language model (LLM) interpretability, such as sparse autoencoders (SAEs), offer a way to decode LLM activations into interpretable and, ideally, controllable concepts. On the one hand, these approaches…

Machine Learning · Computer Science 2026-03-03 Shruti Joshi , Andrea Dittadi , Sébastien Lachapelle , Dhanya Sridhar

We study how reliably sparse autoencoders (SAEs) support claims about reasoning-related internal features in large language models. We first give a stylized analysis showing that sparsity-regularized decoding can preferentially retain…

Machine Learning · Computer Science 2026-05-19 George Ma , Zhongyuan Liang , Irene Y. Chen , Somayeh Sojoudi

Sparse autoencoders (SAEs) have been applied to large language models and protein language models, but not systematically to electronic health record (EHR) foundation models. We train TopK SAEs on FlatASCEND, a 14.5-million-parameter…

Machine Learning · Computer Science 2026-05-07 Chris Sainsbury , Feng Dong , Andreas Karwath

Recent advances in explainable machine learning have highlighted the potential of sparse autoencoders in uncovering mono-semantic features in densely encoded embeddings. While most research has focused on Large Language Model (LLM)…

Computation and Language · Computer Science 2025-02-04 Daniel Pluth , Yu Zhou , Vijay K. Gurbani

Sparse autoencoders (SAEs) are used to analyze embeddings, but their role and practical value are debated. We propose a new perspective on SAEs by demonstrating that they can be naturally understood as topic models. We propose a continuous…

Computer Vision and Pattern Recognition · Computer Science 2026-05-19 Leander Girrbach , Zeynep Akata

Sparse autoencoders (SAEs) are a recent technique for decomposing neural network activations into human-interpretable features. However, in order for SAEs to identify all features represented in frontier models, it will be necessary to…

Machine Learning · Computer Science 2025-06-04 Anish Mudide , Joshua Engels , Eric J. Michaud , Max Tegmark , Christian Schroeder de Witt

Sparse autoencoders (SAEs) are used to disentangle the dense, polysemantic internal representations of large language models (LLMs) into interpretable, monosemantic concepts. However, standard $\ell_1$-regularized SAEs suffer from feature…

Machine Learning · Computer Science 2026-05-08 Faris Chaudhry , Keisuke Yano , Anthea Monod

Recent developments in Large Language Model (LLM) capabilities have brought great potential but also posed new risks. For example, LLMs with knowledge of bioweapons, advanced chemistry, or cyberattacks could cause violence if placed in the…

Machine Learning · Computer Science 2025-03-17 Matthew Khoriaty , Andrii Shportko , Gustavo Mercier , Zach Wood-Doughty

Fine-tuning Pre-trained protein language models (PLMs) has emerged as a prominent strategy for enhancing downstream prediction tasks, often outperforming traditional supervised learning approaches. As a widely applied powerful technique in…

Computation and Language · Computer Science 2024-04-24 Yang Tan , Mingchen Li , Bingxin Zhou , Bozitao Zhong , Lirong Zheng , Pan Tan , Ziyi Zhou , Huiqun Yu , Guisheng Fan , Liang Hong

Sparse Autoencoders (SAEs) have emerged as a powerful unsupervised method for extracting sparse representations from language models, yet scalable training remains a significant challenge. We introduce a suite of 256 SAEs, trained on each…

Pathology plays an important role in disease diagnosis, treatment decision-making and drug development. Previous works on interpretability for machine learning models on pathology images have revolved around methods such as attention value…

Effective representations of protein sequences are widely recognized as a cornerstone of machine learning-based protein design. Yet, protein bioengineering poses unique challenges for sequence representation, as experimental datasets…

Quantitative Methods · Quantitative Biology 2026-04-07 Ana F. Rodrigues , Lucas Ferraz , Laura Balbi , Pedro Giesteira Cotovio , Catia Pesquita

Current sparse autoencoder (SAE) approaches to neural network interpretability assume that activations can be decomposed through linear superposition into sparse, interpretable features. Despite high reconstruction fidelity, SAEs…

Neurons and Cognition · Quantitative Biology 2025-12-10 Omar Claflin

Identifying the features learned by neural networks is a core challenge in mechanistic interpretability. Sparse autoencoders (SAEs), which learn a sparse, overcomplete dictionary that reconstructs a network's internal activations, have been…

Machine Learning · Computer Science 2024-05-27 Dan Braun , Jordan Taylor , Nicholas Goldowsky-Dill , Lee Sharkey

Sparse autoencoders (SAEs) are increasingly used for safety-relevant applications including alignment detection and model steering. These use cases require SAE latents to be as atomic as possible. Each latent should represent a single…

Machine Learning · Computer Science 2026-04-07 Matthew Levinson

To truly understand vision models, we must not only interpret their learned features but also validate these interpretations through controlled experiments. While earlier work offers either rich semantics or direct control, few post-hoc…

Computer Vision and Pattern Recognition · Computer Science 2025-11-25 Samuel Stevens , Wei-Lun Chao , Tanya Berger-Wolf , Yu Su

Sparse autoencoders (SAEs) have gained a lot of attention as a promising tool to improve the interpretability of large language models (LLMs) by mapping the complex superposition of polysemantic neurons into monosemantic features and…

Computation and Language · Computer Science 2025-02-19 Gouki Minegishi , Hiroki Furuta , Yusuke Iwasawa , Yutaka Matsuo

Large Language Models (LLMs) have achieved strong complex reasoning capabilities through Chain-of-Thought (CoT) reasoning. However, their reasoning patterns remain too complicated to analyze. While Sparse Autoencoders (SAEs) have emerged as…

Machine Learning · Computer Science 2026-03-04 Xuan Yang , Jiayu Liu , Yuhang Lai , Hao Xu , Zhenya Huang , Ning Miao