English
Related papers

Related papers: Sparse Autoencoders for Low-$N$ Protein Function P…

200 papers

Sparse autoencoders (SAEs) are widely used in mechanistic interpretability research for large language models; however, the state-of-the-art method of using $k$-sparse autoencoders lacks a theoretical grounding for selecting the…

Machine Learning · Computer Science 2025-08-11 Sewoong Lee , Adam Davies , Marc E. Canby , Julia Hockenmaier

Sparse autoencoders (SAEs) are a promising technique for decomposing language model activations into interpretable linear features. However, current SAEs fall short of completely explaining model performance, resulting in "dark matter":…

Machine Learning · Computer Science 2025-03-26 Joshua Engels , Logan Riggs , Max Tegmark

Sparse autoencoders (SAEs) are designed to extract interpretable features from language models by enforcing a sparsity constraint. Ideally, training an SAE would yield latents that are both sparse and semantically meaningful. However, many…

Machine Learning · Computer Science 2025-11-06 Xiaoqing Sun , Alessandro Stolfo , Joshua Engels , Ben Wu , Senthooran Rajamanoharan , Mrinmaya Sachan , Max Tegmark

Accurate prediction of enzymatic activity from amino acid sequences could drastically accelerate enzyme engineering for applications such as bioremediation and therapeutics development. In recent years, Protein Language Model (PLM)…

Quantitative Methods · Quantitative Biology 2025-05-07 Duncan F. Muir , Parker Grosjean , Margaux M. Pinney , Michael J. Keiser

Sparse Autoencoders (SAEs) are a promising approach for extracting neural network representations by learning a sparse and overcomplete decomposition of the network's internal activations. However, SAEs are traditionally trained considering…

Machine Learning · Computer Science 2025-04-02 Jeffrey Olmo , Jared Wilson , Max Forsey , Bryce Hepner , Thomas Vin Howe , David Wingate

Large language models (LLMs) have demonstrated impressive capabilities in natural language understanding and generation, but controlling their behavior reliably remains challenging, especially in open-ended generation settings. This paper…

Computation and Language · Computer Science 2025-12-08 Zirui He , Mingyu Jin , Bo Shen , Ali Payani , Yongfeng Zhang , Mengnan Du

Sparse autoencoders (SAEs) are used to decompose neural network activations into human-interpretable features. Typically, features learned by a single SAE are used for downstream applications. However, it has recently been shown that SAEs…

Machine Learning · Computer Science 2025-05-23 Soham Gadgil , Chris Lin , Su-In Lee

Sparse autoencoders (SAEs) enable feature-level mechanistic interpretability and activation steering in large language models (LLMs), but SAE-based language control remains unreliable in multilingual settings: most SAEs are trained on…

Computation and Language · Computer Science 2026-05-25 Yusser Al Ghussin , Daniil Gurgurov , Tanja Baeumel , Josef van Genabith , Patrick Schramowski , Simon Ostermann

Understanding and mitigating the potential risks associated with foundation models (FMs) hinges on developing effective interpretability methods. Sparse Autoencoders (SAEs) have emerged as a promising tool for disentangling FM…

Machine Learning · Computer Science 2024-11-04 Aashiq Muhamed , Mona Diab , Virginia Smith

Sparse Autoencoders (SAEs) aim to decompose the activation space of large language models (LLMs) into human-interpretable latent directions or features. As we increase the number of features in the SAE, hierarchical features tend to split…

Computation and Language · Computer Science 2025-11-18 David Chanin , James Wilken-Smith , Tomáš Dulka , Hardik Bhatnagar , Satvik Golechha , Joseph Bloom

Sparse autoencoders (SAEs) have shown promise in extracting interpretable features from complex neural networks. We present one of the first applications of SAEs to dense text embeddings from large language models, demonstrating their…

Machine Learning · Computer Science 2024-08-06 Charles O'Neill , Christine Ye , Kartheik Iyer , John F. Wu

Decomposing model activations into interpretable components is a key open problem in mechanistic interpretability. Sparse autoencoders (SAEs) are a popular method for decomposing the internal activations of trained transformers into sparse,…

Machine Learning · Computer Science 2024-06-26 Connor Kissane , Robert Krzyzanowski , Joseph Isaac Bloom , Arthur Conmy , Neel Nanda

Protein language models (PLMs) have transformed sequence-based protein analysis, yet most applications rely only on final-layer embeddings, which may overlook biologically meaningful information encoded in earlier layers. We systematically…

Quantitative Methods · Quantitative Biology 2025-12-02 Ajit Kumar , IndraPrakash Jha

Large language models (LLMs) store vast amounts of information, making them powerful yet raising privacy and safety concerns when selective knowledge removal is required. Existing unlearning strategies, ranging from gradient-based…

Computation and Language · Computer Science 2025-06-02 Xu Wang , Zihao Li , Benyou Wang , Yan Hu , Difan Zou

A common goal of mechanistic interpretability is to decompose the activations of neural networks into features: interpretable properties of the input computed by the model. Sparse autoencoders (SAEs) are a popular method for finding these…

Machine Learning · Computer Science 2025-02-10 Patrick Leask , Bart Bussmann , Michael Pearce , Joseph Bloom , Curt Tigges , Noura Al Moubayed , Lee Sharkey , Neel Nanda

Continuing advances in neural interfaces have enabled simultaneous monitoring of spiking activity from hundreds to thousands of neurons. To interpret these large-scale data, several methods have been proposed to infer latent dynamic…

Machine Learning · Computer Science 2019-08-23 Mohammad Reza Keshtkaran , Chethan Pandarinath

Sparse autoencoders (SAEs) have become an important tool for analyzing and interpreting the activation space of transformer-based language models (LMs). However, SAEs suffer several shortcomings that diminish their utility and internal…

Computation and Language · Computer Science 2025-06-27 Ryosuke Takahashi , Tatsuro Inaba , Kentaro Inui , Benjamin Heinzerling

Scientific archives now contain hundreds of petabytes of data across genomics, ecology, climate, and molecular biology that could reveal undiscovered patterns if systematically analyzed at scale. Large-scale, weakly-supervised datasets in…

Computer Vision and Pattern Recognition · Computer Science 2025-11-25 Samuel Stevens , Jacob Beattie , Tanya Berger-Wolf , Yu Su

What latent features are encoded in language model (LM) representations? Recent work on training sparse autoencoders (SAEs) to disentangle interpretable features in LM representations has shown significant promise. However, evaluating the…

Sparse autoencoders (SAEs) model the activations of a neural network as linear combinations of sparsely occurring directions of variation (latents). The ability of SAEs to reconstruct activations follows scaling laws w.r.t. the number of…

Machine Learning · Computer Science 2025-09-05 Eric J. Michaud , Liv Gorton , Tom McGrath