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Inspired by the masked language modeling (MLM) in natural language processing tasks, the masked image modeling (MIM) has been recognized as a strong self-supervised pre-training method in computer vision. However, the high random mask ratio…

Computer Vision and Pattern Recognition · Computer Science 2024-06-04 Zhaowen Li , Yousong Zhu , Zhiyang Chen , Wei Li , Chaoyang Zhao , Rui Zhao , Ming Tang , Jinqiao Wang

Large-scale Protein Language Models (PLMs) have improved performance in protein prediction tasks, ranging from 3D structure prediction to various function predictions. In particular, AlphaFold, a ground-breaking AI system, could potentially…

Quantitative Methods · Quantitative Biology 2022-10-18 Mingyang Hu , Fajie Yuan , Kevin K. Yang , Fusong Ju , Jin Su , Hui Wang , Fei Yang , Qiuyang Ding

Protein language models are trained primarily with masked language modeling (MLM), which predicts amino-acid identities at masked positions. We ask whether latent-space prediction can complement these token-level objectives under matched…

Machine Learning · Computer Science 2026-05-11 Dan Ofer , Dafna Shahaf , Michal Linial

Understanding the relationships between protein sequence, structure and function is a long-standing biological challenge with manifold implications from drug design to our understanding of evolution. Recently, protein language models have…

Quantitative Methods · Quantitative Biology 2024-01-29 Dexiong Chen , Philip Hartout , Paolo Pellizzoni , Carlos Oliver , Karsten Borgwardt

As Large Language Models become integral to software development, with substantial portions of AI-suggested code entering production, understanding their internal correctness mechanisms becomes critical for safe deployment. We apply sparse…

Software Engineering · Computer Science 2025-10-06 Kriz Tahimic , Charibeth Cheng

Adapting foundation models for specific purposes has become a standard approach to build machine learning systems for downstream applications. Yet, it is an open question which mechanisms take place during adaptation. Here we develop a new…

Computer Vision and Pattern Recognition · Computer Science 2025-03-24 Hyesu Lim , Jinho Choi , Jaegul Choo , Steffen Schneider

Sparse autoencoders (SAEs) have emerged as a powerful technique for extracting human-interpretable features from neural networks activations. Previous works compared different models based on SAE-derived features but those comparisons have…

Computer Vision and Pattern Recognition · Computer Science 2025-07-25 Clément Cornet , Romaric Besançon , Hervé Le Borgne

With the exponential increase of the protein sequence databases over time, multiple-sequence alignment (MSA) methods, like PSI-BLAST, perform exhaustive and time-consuming database search to retrieve evolutionary information. The resulting…

Quantitative Methods · Quantitative Biology 2023-08-21 Issar Arab

Sparse autoencoders (SAEs) interpret neural network representations by decomposing activations into sparse combinations of dictionary atoms. However, SAEs assume features combine additively through linear reconstruction, an assumption that…

Machine Learning · Computer Science 2026-05-26 Panagiotis Koromilas , Andreas D. Demou , James Oldfield , Yannis Panagakis , Mihalis Nicolaou

SAEs have recently been employed as a promising unsupervised approach for understanding the representations of layers of Large Language Models (LLMs). However, with the growth in model size and complexity, training SAEs is computationally…

Computation and Language · Computer Science 2025-09-23 Davide Ghilardi , Federico Belotti , Marco Molinari , Tao Ma , Matteo Palmonari

Sparse autoencoders (SAEs) are a promising approach to extracting features from neural networks, enabling model interpretability as well as causal interventions on model internals. SAEs generate sparse feature representations using a…

Machine Learning · Computer Science 2024-11-11 Kola Ayonrinde

Variational autoencoders (VAEs) have been used extensively to discover low-dimensional latent factors governing neural activity and animal behavior. However, without careful model selection, the uncovered latent factors may reflect noise in…

Machine Learning · Computer Science 2023-12-13 Julia Huiming Wang , Dexter Tsin , Tatiana Engel

Improving Sparse Autoencoders (SAEs) requires benchmarks that can precisely validate architectural innovations. However, current SAE benchmarks on LLMs are often too noisy to differentiate architectural improvements, and current synthetic…

Machine Learning · Computer Science 2026-02-17 David Chanin , Adrià Garriga-Alonso

Sparse Autoencoders (SAEs) have emerged as a promising solution for decomposing large language model representations into interpretable features. However, Paulo and Belrose (2025) have highlighted instability across different initialization…

Machine Learning · Computer Science 2025-06-24 Seonglae Cho , Harryn Oh , Donghyun Lee , Luis Eduardo Rodrigues Vieira , Andrew Bermingham , Ziad El Sayed

Sparse Autoencoders (SAEs) are widely used to steer large language models (LLMs), based on the assumption that their interpretable features naturally enable effective model behavior steering. Yet, a fundamental question remains unanswered:…

Machine Learning · Computer Science 2025-10-07 Xu Wang , Yan Hu , Benyou Wang , Difan Zou

Sparse autoencoders (SAEs) have been successfully used to discover sparse and human-interpretable representations of the latent activations of LLMs. However, we would ultimately like to understand the computations performed by LLMs and not…

Machine Learning · Computer Science 2025-06-09 Lucy Farnik , Tim Lawson , Conor Houghton , Laurence Aitchison

Determining company similarity is a vital task in finance, underpinning risk management, hedging, and portfolio diversification. Practitioners often rely on sector and industry classifications such as SIC and GICS codes to gauge similarity,…

In this work, we demonstrate that affine mappings between residual streams of language models is a cheap way to effectively transfer represented features between models. We apply this technique to transfer the weights of Sparse Autoencoders…

Computation and Language · Computer Science 2025-11-04 Alan Chen , Jack Merullo , Alessandro Stolfo , Ellie Pavlick

Brain MRI foundation models learn rich representations of anatomy, but interpreting what clinical information they encode remains an open problem. Standard sparse autoencoders (SAEs) suffer from severe feature collapse in deep transformer…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Favour Nerrise , Lucy Yin , Mohammad H. Abbasi , Kilian M. Pohl , Ehsan Adeli

Interpretability is critical in high-stakes domains such as medical imaging, where understanding model decisions is essential for clinical adoption. In this work, we introduce Sparse Autoencoder (SAE)-based interpretability to breast…

Computer Vision and Pattern Recognition · Computer Science 2025-08-19 Krishna Kanth Nakka
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