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There is growing interest in leveraging mechanistic interpretability and controllability to better understand and influence the internal dynamics of large language models (LLMs). However, current methods face fundamental challenges in…

Computation and Language · Computer Science 2025-12-02 Ruben Härle , Felix Friedrich , Manuel Brack , Stephan Wäldchen , Björn Deiseroth , Patrick Schramowski , Kristian Kersting

Sparse Autoencoders (SAEs) extract features from LLM internal activations, meant to correspond to interpretable concepts. A core SAE training hyperparameter is L0: how many SAE features should fire per token on average. Existing work…

Machine Learning · Computer Science 2025-12-08 David Chanin , Adrià Garriga-Alonso

Protein language models (pLMs) produce per-residue representations that capture evolutionary and structural information, yet their mean-pooled sequence embeddings are not explicitly trained to reflect functional, evolutionary or structural…

Machine Learning · Computer Science 2026-05-11 Dan Ofer , Oriel Perets , Michal Linial , Nadav Rappoport

Protein language models (PLMs) have revolutionised computational biology through their ability to generate powerful sequence representations for diverse prediction tasks. However, their black-box nature limits biological interpretation and…

Biomolecules · Quantitative Biology 2025-04-11 Jan van Eck , Dea Gogishvili , Wilson Silva , Sanne Abeln

Sparse Autoencoders (SAEs) are widely used to interpret neural networks by identifying meaningful concepts from their representations. However, do SAEs truly uncover all concepts a model relies on, or are they inherently biased toward…

Machine Learning · Computer Science 2025-12-03 Sai Sumedh R. Hindupur , Ekdeep Singh Lubana , Thomas Fel , Demba Ba

Modern text classification methods heavily rely on contextual embeddings from large language models (LLMs). Compared to human-engineered features, these embeddings provide automatic and effective representations for classification model…

Computation and Language · Computer Science 2025-07-29 Xuansheng Wu , Wenhao Yu , Xiaoming Zhai , Ninghao Liu

Sparse auto-encoders (SAEs) have become a prevalent tool for interpreting language models' inner workings. However, it is unknown how tightly SAE features correspond to computationally important directions in the model. This work…

Machine Learning · Computer Science 2025-02-25 Thomas Dooms , Daniel Wilhelm

Translating the internal representations and computations of models into concepts that humans can understand is a key goal of interpretability. While recent dictionary learning methods such as Sparse Autoencoders (SAEs) provide a promising…

Computation and Language · Computer Science 2026-02-27 Usha Bhalla , Alex Oesterling , Claudio Mayrink Verdun , Himabindu Lakkaraju , Flavio P. Calmon

Recently, sparse autoencoders (SAEs) have emerged as a promising technique for interpreting activations in foundation models by disentangling features into a sparse set of concepts. However, identifying the optimal level of sparsity for…

Machine Learning · Computer Science 2026-04-17 Dongsheng Wang , Jinsen Zhang , Dawei Su , Hui Huang

While sparse autoencoders (SAEs) successfully extract interpretable features from language models, applying them to audio generation faces unique challenges: audio's dense nature requires compression that obscures semantic meaning, and…

Machine Learning · Computer Science 2025-10-31 Nathan Paek , Yongyi Zang , Qihui Yang , Randal Leistikow

For protein sequence datasets, unlabeled data has greatly outpaced labeled data due to the high cost of wet-lab characterization. Recent deep-learning approaches to protein prediction have shown that pre-training on unlabeled data can yield…

Machine Learning · Computer Science 2020-12-02 Pascal Sturmfels , Jesse Vig , Ali Madani , Nazneen Fatema Rajani

Large language models (LLMs) encode a diverse range of linguistic features within their latent representations, which can be harnessed to steer their output toward specific target characteristics. In this paper, we modify the internal…

Computation and Language · Computer Science 2025-02-27 Sumanta Bhattacharyya , Pedram Rooshenas

We introduce sparse autoencoder neural operators (SAE-NOs), a new class of sparse autoencoders that operate in function spaces rather than fixed-dimensional Euclidean representations. We formalize the functional representation hypothesis,…

Machine Learning · Computer Science 2026-05-11 Bahareh Tolooshams , Ailsa Shen , Anima Anandkumar

Software vulnerabilities such as buffer overflows and SQL injections are a major source of security breaches. Traditional methods for vulnerability detection remain essential but are limited by high false positive rates, scalability issues,…

Software Engineering · Computer Science 2026-04-10 Rui Melo , Claudia Mamede , Andre Catarino , Rui Abreu , Henrique Lopes Cardoso

Existing works are dedicated to untangling atomized numerical components (features) from the hidden states of Large Language Models (LLMs). However, they typically rely on autoencoders constrained by some training-time regularization on…

Machine Learning · Computer Science 2026-02-13 Hakaze Cho , Haolin Yang , Yanshu Li , Brian M. Kurkoski , Naoya Inoue

Proteins adopt multiple structural conformations to perform their diverse biological functions, and understanding these conformations is crucial for advancing drug discovery. Traditional physics-based simulation methods often struggle with…

Biomolecules · Quantitative Biology 2025-03-14 Jiarui Lu , Xiaoyin Chen , Stephen Zhewen Lu , Chence Shi , Hongyu Guo , Yoshua Bengio , Jian Tang

Sparse autoencoders (SAEs) extract human-interpretable features from deep neural networks by transforming their activations into a sparse, higher dimensional latent space, and then reconstructing the activations from these latents.…

Machine Learning · Computer Science 2025-02-13 Gonçalo Paulo , Stepan Shabalin , Nora Belrose

Motivated by the hypothesis that neural network representations encode abstract, interpretable features as linearly accessible, approximately orthogonal directions, sparse autoencoders (SAEs) have become a popular tool in interpretability.…

Machine Learning · Computer Science 2025-11-05 Valérie Costa , Thomas Fel , Ekdeep Singh Lubana , Bahareh Tolooshams , Demba Ba

Sparse autoencoders (SAEs) have proven effective for extracting monosemantic features from large language models (LLMs), yet these features are typically identified in isolation. However, broad evidence suggests that LLMs capture the…

Artificial Intelligence · Computer Science 2026-02-13 Yifan Luo , Yang Zhan , Jiedong Jiang , Tianyang Liu , Mingrui Wu , Zhennan Zhou , Bin Dong

The capability of accurate prediction of protein functions and properties is essential in the biotechnology industry, e.g. drug development and artificial protein synthesis, etc. The main challenges of protein function prediction are the…

Quantitative Methods · Quantitative Biology 2021-12-02 Wei-Cheng Tseng , Po-Han Chi , Jia-Hua Wu , Min Sun