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Large language models (LLMs) have shown remarkable performance on many tasks in different domains. However, their performance in closed-book biomedical machine reading comprehension (MRC) has not been evaluated in depth. In this work, we…

Computation and Language · Computer Science 2024-10-28 Shubham Vatsal , Ayush Singh

Alignment of large language models (LLMs) with human preferences typically relies on supervised reward models or external judges that demand abundant annotations. However, in fields that rely on professional knowledge, such as medicine and…

Artificial Intelligence · Computer Science 2025-11-18 Yiyang Zhao , Huiyu Bai , Xuejiao Zhao

Recent advancements in large language models (LLMs) have shown strong performance in natural language understanding and generation tasks. However, LLMs continue to encounter challenges with hallucinations, where models generate plausible…

Computation and Language · Computer Science 2025-10-15 Jung-Woo Shim , Yeong-Joon Ju , Ji-Hoon Park , Seong-Whan Lee

Prompting has shown impressive success in enabling large pretrained language models (LMs) to perform diverse NLP tasks, especially when only few downstream data are available. Automatically finding the optimal prompt for each task, however,…

Computation and Language · Computer Science 2022-10-25 Mingkai Deng , Jianyu Wang , Cheng-Ping Hsieh , Yihan Wang , Han Guo , Tianmin Shu , Meng Song , Eric P. Xing , Zhiting Hu

Large language models (LLMs) have achieved strong performance on medical exam-style tasks, motivating growing interest in their deployment in real-world clinical settings. However, clinical decision-making is inherently safety-critical,…

Computation and Language · Computer Science 2026-04-13 Xiaohan Ren , Chenxiao Fan , Wenyin Ma , Hongliang He , Chongming Gao , Xiaoyan Zhao , Fuli Feng

Prompt optimization and fine-tuning are two major approaches to improve the performance of Large Language Models (LLMs). They enhance the capabilities of LLMs from complementary perspectives: the former through explicit natural language,…

Computation and Language · Computer Science 2026-03-03 Xiaohe Bo , Rui Li , Zexu Sun , Quanyu Dai , Zeyu Zhang , Zihang Tian , Xu Chen , Zhenhua Dong

Recent advances in prompt optimization have notably enhanced the performance of pre-trained language models (PLMs) on downstream tasks. However, the potential of optimized prompts on domain generalization has been under-explored. To explore…

Computation and Language · Computer Science 2024-10-22 Chengzhengxu Li , Xiaoming Liu , Zhaohan Zhang , Yichen Wang , Chen Liu , Yu Lan , Chao Shen

Reasoning has substantially improved the performance of large language models (LLMs) on complicated tasks. Central to the current reasoning studies, Process Reward Models (PRMs) offer a fine-grained evaluation of intermediate reasoning…

Machine Learning · Computer Science 2025-11-05 Qi Cao , Ruiyi Wang , Ruiyi Zhang , Sai Ashish Somayajula , Pengtao Xie

System prompts are a central control mechanism in modern AI systems, shaping behavior across conversations, tasks, and user populations. Yet they are difficult to tune when feedback is available only as aggregate metrics rather than…

Artificial Intelligence · Computer Science 2026-05-20 Zhiyuan Jerry Lin , Benjamin Letham , Samuel Dooley , Maximilian Balandat , Eytan Bakshy

Pre-trained vision-language models are able to interpret visual concepts and language semantics. Prompt learning, a method of constructing prompts for text encoders or image encoders, elicits the potentials of pre-trained models and readily…

Computer Vision and Pattern Recognition · Computer Science 2025-02-21 Zhenhan Huang , Tejaswini Pedapati , Pin-Yu Chen , Jianxi Gao

Entity Resolution (ER) is the problem of semi-automatically determining when two entities refer to the same underlying entity, with applications ranging from healthcare to e-commerce. Traditional ER solutions required considerable manual…

Artificial Intelligence · Computer Science 2024-04-09 Navapat Nananukul , Khanin Sisaengsuwanchai , Mayank Kejriwal

Large Language Models (LLMs) have demonstrated substantial progress in biomedical and clinical applications, motivating rigorous evaluation of their ability to answer nuanced, evidence-based questions. We curate a multi-source benchmark…

Computation and Language · Computer Science 2025-09-16 Can Wang , Yiqun Chen

Medical automatic diagnosis aims to imitate human doctors in real-world diagnostic processes and to achieve accurate diagnoses by interacting with the patients. The task is formulated as a sequential decision-making problem with a series of…

Machine Learning · Computer Science 2022-06-07 Hongyi Yuan , Sheng Yu

System prompts provide a lightweight yet powerful mechanism for conditioning large language models (LLMs) at inference time. While prior work has focused on English-only settings, real-world deployments benefit from having a single prompt…

Computation and Language · Computer Science 2025-12-03 Lechen Zhang , Yusheng Zhou , Tolga Ergen , Lajanugen Logeswaran , Moontae Lee , David Jurgens

Reasoning is a critical frontier for advancing medical image analysis, where transparency and trustworthiness play a central role in both clinician trust and regulatory approval. Although Medical Visual Language Models (VLMs) show promise…

Computer Vision and Pattern Recognition · Computer Science 2025-03-20 Jiazhen Pan , Che Liu , Junde Wu , Fenglin Liu , Jiayuan Zhu , Hongwei Bran Li , Chen Chen , Cheng Ouyang , Daniel Rueckert

Aligning Large Language Models (LLMs) with human preferences is critical, yet traditional fine-tuning methods are computationally expensive and inflexible. While test-time alignment offers a promising alternative, existing approaches often…

Artificial Intelligence · Computer Science 2026-01-16 Tiesunlong Shen , Rui Mao , Jin Wang , Heming Sun , Jian Zhang , Xuejie Zhang , Erik Cambria

Large language models (LLMs) have recently been employed as agents to solve sequential decision-making tasks such as Bayesian optimization and multi-armed bandits (MAB). These works usually adopt an LLM for sequential action selection by…

Machine Learning · Computer Science 2025-02-04 Mingze Kong , Zhiyong Wang , Yao Shu , Zhongxiang Dai

In this paper, we explore the potential of Large Language Models (LLMs) with assertions to mitigate imbalances in educational datasets. Traditional models often fall short in such contexts, particularly due to the complexity and nuanced…

Computers and Society · Computer Science 2024-07-03 Jeanne McClure , Machi Shimmei , Noboru Matsuda , Shiyan Jiang

Generalized Entity Matching (GEM), which aims at judging whether two records represented in different formats refer to the same real-world entity, is an essential task in data management. The prompt tuning paradigm for pre-trained language…

Computation and Language · Computer Science 2024-05-09 Yikuan Xia , Jiazun Chen , Xinchi Li , Jun Gao

Streaming services have reshaped how we discover and engage with digital entertainment. Despite these advancements, effectively understanding the wide spectrum of user search queries continues to pose a significant challenge. An accurate…

Information Retrieval · Computer Science 2024-09-16 Farnoosh Javadi , Phanideep Gampa , Alyssa Woo , Xingxing Geng , Hang Zhang , Jose Sepulveda , Belhassen Bayar , Fei Wang