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Background: The potential of large language models (LLMs) to automate and support pharmacoepidemiologic study design is an emerging area of interest, yet their reliability remains insufficiently characterized. General-purpose LLMs often…

Computation and Language · Computer Science 2026-04-21 Xinyao Zhang , Nicole Sonne Heckmann , Manuela Del Castillo Suero , Francesco Paolo Speca , Maurizio Sessa

Large Language Models (LLMs) have shown promising capabilities for solving Operations Research (OR) problems. While reinforcement learning serves as a powerful paradigm for LLM training on OR problems, existing works generally face two key…

Artificial Intelligence · Computer Science 2025-10-03 Chenyu Zhou , Tianyi Xu , Jianghao Lin , Dongdong Ge

Large language models (LLMs) are increasingly explored for clinical decision support, yet most evaluations are conducted in English, leaving their reliability in other languages uncertain. Here we evaluate the impact of prompting language…

Computation and Language · Computer Science 2026-05-20 Adrien Bazoge , Josselin Corvellec , Sofiane Djillali Sid-Ahmed , Pierre-Antoine Gourraud

The clinical adoption of biomedical vision-language models is hindered by prompt optimization techniques that produce either uninterpretable latent vectors or single textual prompts. This lack of transparency and failure to capture the…

Computer Vision and Pattern Recognition · Computer Science 2025-10-20 Kaushitha Silva , Mansitha Eashwara , Sanduni Ubayasiri , Ruwan Tennakoon , Damayanthi Herath

Large language models (LLMs) have shown great potential in medical question answering (MedQA), yet adapting them to biomedical reasoning remains challenging due to domain-specific complexity and limited supervision. In this work, we study…

Computation and Language · Computer Science 2025-11-12 Chenqian Le , Ziheng Gong , Chihang Wang , Haowei Ni , Panfeng Li , Xupeng Chen

The shift toward interacting with frozen, "black-box" Large Language Models (LLMs) has transformed prompt engineering from a heuristic exercise into a critical optimization challenge. We propose a Reinforcement Learning (RL) framework for…

Artificial Intelligence · Computer Science 2026-05-15 Krishna Sayana , Ketan Todi , Ambarish Jash

Large language models (LLMs) have transformed AI across diverse domains, with prompting being central to their success in guiding model outputs. However, manual prompt engineering is both labor-intensive and domain-specific, necessitating…

Computation and Language · Computer Science 2024-10-04 Eshaan Agarwal , Joykirat Singh , Vivek Dani , Raghav Magazine , Tanuja Ganu , Akshay Nambi

Despite the rapid expansion of Large Language Models (LLMs) in healthcare, robust and explainable evaluation of their ability to assess clinical trial reporting according to CONSORT standards remains an open challenge. In particular,…

Artificial Intelligence · Computer Science 2026-02-26 Sohyeon Jeon , Hyung-Chul Lee

Large Language Models (LLMs) have demonstrated exceptional abilities across a broad range of language-related tasks, including generating solutions to complex reasoning problems. An effective technique to enhance LLM performance is…

Computation and Language · Computer Science 2024-12-25 Shuzhang Cai , Twumasi Mensah-Boateng , Xander Kuksov , Jing Yuan , Shaojie Tang

Recent advances have shown that optimizing prompts for Large Language Models (LLMs) can significantly improve task performance, yet many optimization techniques rely on heuristics or manual exploration. We present LatentPrompt, a…

Computation and Language · Computer Science 2025-08-05 Mateusz Bystroński , Grzegorz Piotrowski , Nitesh V. Chawla , Tomasz Kajdanowicz

This work presents our participation in the EvalLLM 2025 challenge on biomedical Named Entity Recognition (NER) and health event extraction in French (few-shot setting). For NER, we propose three approaches combining large language models…

Large Language Models (LLMs) have demonstrated remarkable performance across various tasks by effectively utilizing a prompting strategy. However, they are highly sensitive to input perturbations, such as typographical errors or slight…

Computation and Language · Computer Science 2026-05-27 Lin Mu , Guowei Chu , Li Ni , Lei Sang , Yiwen Zhang

Several works have proven that finetuning is an applicable approach for debiasing contextualized word embeddings. Similarly, discrete prompts with semantic meanings have shown to be effective in debiasing tasks. With unfixed mathematical…

Computation and Language · Computer Science 2025-05-27 Ke Yang , Charles Yu , Yi Fung , Manling Li , Heng Ji

Large language models (LLMs) are gaining increasing interests to improve clinical efficiency for medical diagnosis, owing to their unprecedented performance in modelling natural language. Ensuring the safe and reliable clinical…

Computation and Language · Computer Science 2024-03-26 Lei Liu , Xiaoyan Yang , Fangzhou Li , Chenfei Chi , Yue Shen , Shiwei Lyu Ming Zhang , Xiaowei Ma , Xiangguo Lyu , Liya Ma , Zhiqiang Zhang , Wei Xue , Yiran Huang , Jinjie Gu

Large Language Models exhibit mode collapse, producing homogeneous outputs that fail to explore valid solution spaces. We present QD-LLM, a framework for parameter-efficient neuroevolution that evolves prompt embeddings, compact neural…

Neural and Evolutionary Computing · Computer Science 2026-05-12 Dongxin Guo , Jikun Wu , Siu Ming Yiu

Prompt optimization improves the reasoning abilities of large language models (LLMs) without requiring parameter updates to the target model. Following heuristic-based "Think step by step" approaches, the field has evolved in two main…

Computation and Language · Computer Science 2025-07-25 Andreea Nica , Ivan Zakazov , Nicolas Mario Baldwin , Saibo Geng , Robert West

Modern large language models (LLMs) are often evaluated and deployed under a one-shot, greedy inference protocol, especially in professional settings that require deterministic behavior. This regime can systematically under-estimate a fixed…

Artificial Intelligence · Computer Science 2026-02-13 Xinhai Sun

Large language models (LLMs) have shown remarkable performance in vision-language tasks, but their application in the medical field remains underexplored, particularly for integrating structured time series data with unstructured clinical…

Computation and Language · Computer Science 2025-06-17 Shuai Niu , Jing Ma , Hongzhan Lin , Liang Bai , Zhihua Wang , Wei Bi , Yida Xu , Guo Li , Xian Yang

The introduction of large language models (LLMs) has enhanced automation in software engineering tasks, including in Model Driven Engineering (MDE). However, using general-purpose LLMs for domain modeling has its limitations. One approach…

Software Engineering · Computer Science 2025-07-22 Vladyslav Bulhakov , Giordano d'Aloisio , Claudio Di Sipio , Antinisca Di Marco , Davide Di Ruscio

In this paper, we conduct a comprehensive SWOT analysis of prompt engineering techniques within the realm of Large Language Models (LLMs). Emphasizing linguistic principles, we examine various techniques to identify their strengths,…

Computation and Language · Computer Science 2024-10-18 Aditi Singh , Abul Ehtesham , Gaurav Kumar Gupta , Nikhil Kumar Chatta , Saket Kumar , Tala Talaei Khoei
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