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Accurate whole-cell and nuclear segmentation is essential for precision pathology and spatial omics, yet routine hematoxylin and eosin (H&E) staining provides limited cytoplasmic contrast, restricting analyses to nuclei. Multiplex…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Yasin Shokrollahi , Karina B. Pinao Gonzales , Elizve N. Barrientos Toro , Paul Acosta , Patient Mosaic Team , Pingjun Chen , Yinyin Yuan , Xiaoxi Pan

Advancements in deep generative models such as generative adversarial networks and variational autoencoders have resulted in the ability to generate realistic images that are visually indistinguishable from real images, which raises…

Image and Video Processing · Electrical Eng. & Systems 2021-02-16 Tarik Dzanic , Karan Shah , Freddie Witherden

Immunohistochemistry (IHC) biomarkers are essential tools for reliable cancer diagnosis and subtyping. It requires cross-staining comparison among Whole Slide Images (WSIs) of IHCs and hematoxylin and eosin (H&E) slides. Currently,…

Image and Video Processing · Electrical Eng. & Systems 2023-12-27 Abubakr Shafique , Morteza Babaie , Ricardo Gonzalez , Adrian Batten , Soma Sikdar , H. R. Tizhoosh

Quantum machine learning (QML) has received increasing attention due to its potential to outperform classical machine learning methods in problems pertaining classification and identification tasks. A subclass of QML methods is quantum…

Quantum Physics · Physics 2023-10-24 Shu Lok Tsang , Maxwell T. West , Sarah M. Erfani , Muhammad Usman

There is a significant need for the generation of virtual histological information from coronary optical coherence tomography (OCT) images to better guide the treatment of coronary artery disease. However, existing methods either require a…

Image and Video Processing · Electrical Eng. & Systems 2023-07-25 Xueshen Li , Hongshan Liu , Xiaoyu Song , Brigitta C. Brott , Silvio H. Litovsky , Yu Gan

Conventional hematoxylin-eosin (H&E) staining is limited to revealing cell morphology and distribution, whereas immunohistochemical (IHC) staining provides precise and specific visualization of protein activation at the molecular level.…

Image and Video Processing · Electrical Eng. & Systems 2024-07-30 Fuqiang Chen , Ranran Zhang , Boyun Zheng , Yiwen Sun , Jiahui He , Wenjian Qin

Histological Tertiary Lymphoid Structures (TLSs) are increasingly recognized for their correlation with the efficacy of immunotherapy in various solid tumors. Traditionally, the identification and characterization of TLSs rely on…

Image and Video Processing · Electrical Eng. & Systems 2024-08-27 Qiuli Wang , Yongxu Liu , Li Ma , Xianqi Wang , Wei Chen , Xiaohong Yao

Immunohistochemistry (IHC) plays a crucial role in pathology as it detects the over-expression of protein in tissue samples. However, there are still fewer machine learning model studies on IHC's impact on accurate cancer grading. We…

Computer Vision and Pattern Recognition · Computer Science 2024-05-15 Jun Wang , Yu Mao , Yufei Cui , Nan Guan , Chun Jason Xue

A multi-layer image is more valuable than a single-layer image from a graphic designer's perspective. However, most of the proposed image generation methods so far focus on single-layer images. In this paper, we propose MontageGAN, which is…

Computer Vision and Pattern Recognition · Computer Science 2022-06-01 Chean Fei Shee , Seiichi Uchida

Recent advancements in graph-based approaches for multiplexed immunofluorescence (mIF) images have significantly propelled the field forward, offering deeper insights into patient-level phenotyping. However, current graph-based…

Computer Vision and Pattern Recognition · Computer Science 2024-07-26 Sukwon Yun , Jie Peng , Alexandro E. Trevino , Chanyoung Park , Tianlong Chen

In medical imaging, access to data is commonly limited due to patient privacy restrictions and the issue that it can be difficult to acquire enough data in the case of rare diseases.[1] The purpose of this investigation was to develop a…

Computer Vision and Pattern Recognition · Computer Science 2024-03-29 John R. McNulty , Lee Kho , Alexandria L. Case , Charlie Fornaca , Drew Johnston , David Slater , Joshua M. Abzug , Sybil A. Russell

As many other machine learning driven medical image analysis tasks, skin image analysis suffers from a chronic lack of labeled data and skewed class distributions, which poses problems for the training of robust and well-generalizing…

Computer Vision and Pattern Recognition · Computer Science 2018-09-07 Christoph Baur , Shadi Albarqouni , Nassir Navab

3D-aware image synthesis aims to generate images of objects from multiple views by learning a 3D representation. However, one key challenge remains: existing approaches lack geometry constraints, hence usually fail to generate multi-view…

Computer Vision and Pattern Recognition · Computer Science 2022-04-14 Xuanmeng Zhang , Zhedong Zheng , Daiheng Gao , Bang Zhang , Pan Pan , Yi Yang

Recent proposals for quantum generative adversarial networks (GANs) suffer from the issue of mode collapse, analogous to classical GANs, wherein the distribution learnt by the GAN fails to capture the high mode complexities of the target…

Quantum Physics · Physics 2025-05-23 Aaron Mark Thomas , Harry Youel , Sharu Theresa Jose

Despite recent successes in synthesizing faces and bedrooms, existing generative models struggle to capture more complex image types, potentially due to the oversimplification of their latent space constructions. To tackle this issue,…

Machine Learning · Computer Science 2018-03-13 Wenling Shang , Kihyuk Sohn , Yuandong Tian

Generative adversarial networks (GANs) are a class of unsupervised machine learning algorithms that can produce realistic images from randomly-sampled vectors in a multi-dimensional space. Until recently, it was not possible to generate…

Computer Vision and Pattern Recognition · Computer Science 2018-05-10 Andrew Beers , James Brown , Ken Chang , J. Peter Campbell , Susan Ostmo , Michael F. Chiang , Jayashree Kalpathy-Cramer

Large amounts of digitized histopathological data display a promising future for developing pathological foundation models via self-supervised learning methods. Foundation models pretrained with these methods serve as a good basis for…

Computer Vision and Pattern Recognition · Computer Science 2024-08-07 Shengyi Hua , Fang Yan , Tianle Shen , Lei Ma , Xiaofan Zhang

Histopathology, particularly hematoxylin and eosin (H\&E) staining, plays a critical role in diagnosing and characterizing pathological conditions by highlighting tissue morphology. However, H\&E-stained images inherently lack molecular…

Computational Engineering, Finance, and Science · Computer Science 2025-01-28 Qing Wang , Wen-jie Chen , Bo Li , Jing Su , Guangyu Wang , Qianqian Song

Manual counting of mitotic tumor cells in tissue sections constitutes one of the strongest prognostic markers for breast cancer. This procedure, however, is time-consuming and error-prone. We developed a method to automatically detect…

Magnetic Resonance Imaging (MRI) is a vital modality for gaining precise anatomical information, and it plays a significant role in medical imaging for diagnosis and therapy planning. Image synthesis problems have seen a revolution in…

Image and Video Processing · Electrical Eng. & Systems 2024-04-16 Drici Mourad , Kazeem Oluwakemi Oseni