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This paper develops a memory-efficient approach for Sequential Pattern Mining (SPM), a fundamental topic in knowledge discovery that faces a well-known memory bottleneck for large data sets. Our methodology involves a novel hybrid trie data…

Databases · Computer Science 2024-07-30 Amin Hosseininasab , Willem-Jan van Hoeve , Andre A. Cire

Affordable, high-quality whole-genome assemblies have made it possible to construct rich pangenomes that capture haplotype diversity across many species. As these datasets grow, they motivate the development of specialized techniques…

Genomics · Quantitative Biology 2025-12-19 Gorkem Kadir Solun , Ugur Dogrusoz

Processing large-scale graph datasets is computationally intensive and time-consuming. Processor-centric CPU and GPU architectures, commonly used for graph applications, often face bottlenecks caused by extensive data movement between the…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-02-11 Marzieh Barkhordar , Alireza Tabatabaeian , Mohammad Sadrosadati , Christina Giannoula , Juan Gomez Luna , Izzat El Hajj , Onur Mutlu , Alaa R. Alameldeen

Multiple sequence alignment is a basic procedure in molecular biology, and it is often treated as being essentially a solved computational problem. However, this is not so, and here I review the evidence for this claim, and outline the…

Populations and Evolution · Quantitative Biology 2018-08-24 David A. Morrison

Concurrent data structures often require additional memory for handling synchronization issues in addition to memory for storing elements. Depending on the amount of this additional memory, implementations can be more or less…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-01-17 Vitaly Aksenov , Nikita Koval , Petr Kuznetsov , Anton Paramonov

DNA sequence alignment is an important workload in computational genomics. Reference-guided DNA assembly involves aligning many read sequences against candidate locations in a long reference genome. To reduce the computational load of this…

Hardware Architecture · Computer Science 2024-01-23 Courtney Golden , Dan Ilan , Nicholas Cebry , Christopher Batten

Recent advancements in deep learning have led to the widespread adoption of artificial intelligence (AI) in applications such as computer vision and natural language processing. As neural networks become deeper and larger, AI modeling…

Hardware Architecture · Computer Science 2020-09-30 Eugene Tam , Shenfei Jiang , Paul Duan , Shawn Meng , Yue Pang , Cayden Huang , Yi Han , Jacke Xie , Yuanjun Cui , Jinsong Yu , Minggui Lu

Genetic Programming (GP) is a computationally intensive technique which also has a high degree of natural parallelism. Parallel computing architectures have become commonplace especially with regards Graphics Processing Units (GPU). Hence,…

Distributed, Parallel, and Cluster Computing · Computer Science 2016-01-05 Darren M. Chitty

Protein similarity searches are a routine job for molecular biologists where a query sequence of amino acids needs to be compared and ranked against an ever-growing database of proteins. All available algorithms in this field can be grouped…

Computational Engineering, Finance, and Science · Computer Science 2015-08-27 Akash Nag , Sunil Karforma

Similarity search is one of the most fundamental computations that are regularly performed on ever-increasing protein datasets. Scalability is of paramount importance for uncovering novel phenomena that occur at very large scales. We…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-03-06 Oguz Selvitopi , Saliya Ekanayake , Giulia Guidi , Muaaz G. Awan , Georgios A. Pavlopoulos , Ariful Azad , Nikos Kyrpides , Leonid Oliker , Katherine Yelick , Aydın Buluç

In this paper, we present GradPIM, a processing-in-memory architecture which accelerates parameter updates of deep neural networks training. As one of processing-in-memory techniques that could be realized in the near future, we propose an…

Machine Learning · Computer Science 2021-02-16 Heesu Kim , Hanmin Park , Taehyun Kim , Kwanheum Cho , Eojin Lee , Soojung Ryu , Hyuk-Jae Lee , Kiyoung Choi , Jinho Lee

In this paper we solve on GPUs massive problems with large amount of data, which are not appropriate for solution with the SIMD technology. For the given problem we consider a three-level parallelization. The multithreading of CPU is used…

Distributed, Parallel, and Cluster Computing · Computer Science 2014-02-18 Natalya Litvinenko

At the last step of short read mapping, the candidate locations of the reads on the reference genome are verified to compute their differences from the corresponding reference segments using sequence alignment algorithms. Calculating the…

Genomics · Quantitative Biology 2024-07-04 Zülal Bingöl , Mohammed Alser , Onur Mutlu , Ozcan Ozturk , Can Alkan

A theoretical memory with limited processing power and internal connectivity at each element is proposed. This memory carries out parallel processing within itself to solve generic array problems. The applicability of this in-memory…

Distributed, Parallel, and Cluster Computing · Computer Science 2010-09-28 Chengpu Wang

The sheer sizes of modern datasets are forcing data-structure designers to consider seriously both parallel construction and compactness. To achieve those goals we need to design a parallel algorithm with good scalability and with low…

Data Structures and Algorithms · Computer Science 2017-05-02 Leo Ferres , José Fuentes-Sepúlveda , Travis Gagie , Meng He , Gonzalo Navarro

Bit-serial Processing-In-Memory (PIM) is an attractive paradigm for accelerator architectures, for parallel workloads such as Deep Learning (DL), because of its capability to achieve massive data parallelism at a low area overhead and…

Hardware Architecture · Computer Science 2023-11-21 Aman Arora , Jian Weng , Siyuan Ma , Tony Nowatzki , Lizy K. John

With the rapid growth of AMD as a competitor in the CPU industry, it is imperative that high-performance and architectural engineers analyze new AMD CPUs. By understanding new and unfamiliar architectures, engineers are able to adapt their…

Hardware Architecture · Computer Science 2022-11-23 Phillip Allen Lane , Jessica Lobrano

Fully Homomorphic Encryption (FHE) imposes substantial memory bandwidth demands, presenting significant challenges for efficient hardware acceleration. Near-memory Processing (NMP) has emerged as a promising architectural solution to…

Hardware Architecture · Computer Science 2025-04-01 Shangyi Shi , Husheng Han , Jianan Mu , Xinyao Zheng , Ling Liang , Hang Lu , Zidong Du , Xiaowei Li , Xing Hu , Qi Guo

Memory-aware network scheduling is becoming increasingly important for deep neural network (DNN) inference on resource-constrained devices. However, due to the complex cell-level and network-level topologies, memory-aware scheduling becomes…

Machine Learning · Computer Science 2023-08-29 Shuzhang Zhong , Meng Li , Yun Liang , Runsheng Wang , Ru Huang

It is often said that one of the biggest limitations on computer performance is memory bandwidth (i.e."the memory wall problem"). In this position paper, I argue that if historical trends in computing evolution (where growth in available…

Operating Systems · Computer Science 2011-05-11 Niall Douglas
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