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Sequence alignment algorithms are a basic and critical component of many bioinformatics fields. With rapid development of sequencing technology, the fast growing reference database volumes and longer length of query sequence become new…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-01-09 Bo Xu , Changlong Li , Hang Zhuang , Jiali Wang , Qingfeng Wang , Jinhong Zhou , Xuehai Zhou

Multi-bit spiking neural networks (SNNs) have recently become a heated research spot, pursuing energy-efficient and high-accurate AI. However, with more bits involved, the associated memory and computation demands escalate to the point…

Neural and Evolutionary Computing · Computer Science 2025-12-02 Xingting Yao , Qinghao Hu , Fei Zhou , Tielong Liu , Gang Li , Peisong Wang , Jian Cheng

Over the past decade, the landscape of data analytics has seen a notable shift towards heterogeneous architectures, particularly the integration of GPUs to enhance overall performance. In the realm of in-memory analytics, which often…

Databases · Computer Science 2024-06-21 Harshit Sharma , Anmol Sharma

The growing memory demands of modern applications have driven the adoption of far memory technologies in data centers to provide cost-effective, high-capacity memory solutions. However, far memory presents new performance challenges because…

Hardware Architecture · Computer Science 2024-04-18 Luming Wang , Xu Zhang , Songyue Wang , Zhuolun Jiang , Tianyue Lu , Mingyu Chen , Siwei Luo , Keji Huang

The widespread adoption of Large Language Models (LLMs) has exponentially increased the demand for efficient serving systems. With growing requests and context lengths, key-value (KV)-related operations, including attention computation and…

Hardware Architecture · Computer Science 2026-02-13 Lian Liu , Shixin Zhao , Yutian Zhou , Yintao He , Mengdi Wang , Yinhe Han , Ying Wang

Memory mechanism is a core component of LLM-based agents, enabling reasoning and knowledge discovery over long-horizon contexts. Existing agent memory systems are typically designed within isolated paradigms (e.g., explicit, parametric, or…

Artificial Intelligence · Computer Science 2026-02-10 Xin Zhang , Kailai Yang , Chenyue Li , Hao Li , Qiyu Wei , Jun'ichi Tsujii , Sophia Ananiadou

As an important application of spatial databases in pathology imaging analysis, cross-comparing the spatial boundaries of a huge amount of segmented micro-anatomic objects demands extremely data- and compute-intensive operations, requiring…

Databases · Computer Science 2012-08-02 Kaibo Wang , Yin Huai , Rubao Lee , Fusheng Wang , Xiaodong Zhang , Joel H. Saltz

The increasing complexity of transformer models in artificial intelligence expands their computational costs, memory usage, and energy consumption. Hardware acceleration tackles the ensuing challenges by designing processors and…

Hardware Architecture · Computer Science 2023-12-21 Alireza Amirshahi , Giovanni Ansaloni , David Atienza

One of the primary sources of unpredictability in modern multi-core embedded systems is contention over shared memory resources, such as caches, interconnects, and DRAM. Despite significant achievements in the design and analysis of…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-09-18 Ankit Agrawal , Renato Mancuso , Rodolfo Pellizzoni , Gerhard Fohler

Various methods have been developed to analyze the association between organisms and their genomic sequences. Among them, sequence alignment is the most frequently used for comparative analysis of biological genomes. However, the…

Quantitative Methods · Quantitative Biology 2020-10-27 Yong Joon Song , Dong Jin Ji , Hye In Seo , Gyu Bum Han , Dong Ho Cho

Multi-core architectures feature an intricate hierarchy of cache memories, with multiple levels and sizes. To adequately decompose an application according to the traits of a particular memory hierarchy is a cumbersome task that may be…

Distributed, Parallel, and Cluster Computing · Computer Science 2015-11-20 Hervé Paulino , Nuno Delgado

This work investigates the problem of instance-level image retrieval re-ranking with the constraint of memory efficiency, ultimately aiming to limit memory usage to 1KB per image. Departing from the prevalent focus on performance…

Computer Vision and Pattern Recognition · Computer Science 2024-08-07 Pavel Suma , Giorgos Kordopatis-Zilos , Ahmet Iscen , Giorgos Tolias

Processing-in-memory (PIM) architectures have demonstrated great potential in accelerating numerous deep learning tasks. Particularly, resistive random-access memory (RRAM) devices provide a promising hardware substrate to build PIM…

Hardware Architecture · Computer Science 2022-02-01 Weidong Cao , Yilong Zhao , Adith Boloor , Yinhe Han , Xuan Zhang , Li Jiang

String matching algorithm plays the vital role in the Computational Biology. The functional and structural relationship of the biological sequence is determined by similarities on that sequence. For that, the researcher is supposed to aware…

Data Structures and Algorithms · Computer Science 2014-01-30 Pandiselvam. P , Marimuthu. T , Lawrance. R

Graph Neural Networks (GNNs) are becoming a promising technique in various domains due to their excellent capabilities in modeling non-Euclidean data. Although a spectrum of accelerators has been proposed to accelerate the inference of…

Hardware Architecture · Computer Science 2023-11-17 Zeyu Zhu , Fanrong Li , Gang Li , Zejian Liu , Zitao Mo , Qinghao Hu , Xiaoyao Liang , Jian Cheng

Bioinformatics research is characterized by voluminous and incremental datasets and complex data analytics methods. The machine learning methods used in bioinformatics are iterative and parallel. These methods can be scaled to handle big…

Computational Engineering, Finance, and Science · Computer Science 2015-06-17 Hirak Kashyap , Hasin Afzal Ahmed , Nazrul Hoque , Swarup Roy , Dhruba Kumar Bhattacharyya

We present a novel characterization of the mapping of multiple parallelism forms (e.g. data and model parallelism) onto hierarchical accelerator systems that is hierarchy-aware and greatly reduces the space of software-to-hardware mapping.…

Programming Languages · Computer Science 2021-11-17 Ningning Xie , Tamara Norman , Dominik Grewe , Dimitrios Vytiniotis

The performance gains obtained by large language models (LLMs) are closely linked to their substantial computational and memory requirements. Quantized LLMs offer significant advantages with extremely quantized models, motivating the…

Hardware Architecture · Computer Science 2026-04-07 Ahmed J. Abdelmaksoud , Cristian Sestito , Shiwei Wang , Themis Prodromakis

Memory-centric computing aims to enable computation capability in and near all places where data is generated and stored. As such, it can greatly reduce the large negative performance and energy impact of data access and data movement, by…

Hardware Architecture · Computer Science 2023-09-15 Onur Mutlu

Sequence comparison is a widely used computational technique in modern molecular biology. In spite of the frequent use of sequence comparisons the important problem of assigning statistical significance to a given degree of similarity is…

Quantitative Methods · Quantitative Biology 2007-05-23 Ralf Bundschuh , Nicholas Chia
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