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Results: We present an application that enables the quantitative analysis of multichannel 5-D (x, y, z, t, channel) and large montage confocal fluorescence microscopy images. The image sequences show stem cells together with blood vessels,…

Graphs can be used to effectively represent complex data structures. Learning these irregular data in graphs is challenging and still suffers from shallow learning. Applying deep learning on graphs has recently showed good performance in…

Machine Learning · Computer Science 2020-09-16 Thosini Bamunu Mudiyanselage , Xiujuan Lei , Nipuna Senanayake , Yanqing Zhang , Yi Pan

Cell tracking is a ubiquitous image analysis task in live-cell microscopy. Unlike multiple object tracking (MOT) for natural images, cell tracking typically involves hundreds of similar-looking objects that can divide in each frame, making…

Computer Vision and Pattern Recognition · Computer Science 2024-07-25 Benjamin Gallusser , Martin Weigert

Modern machine learning often relies on optimizing a neural network's parameters using a loss function to learn complex features. Beyond training, examining the loss function with respect to a network's parameters (i.e., as a loss…

In this paper, we consider a tree inference problem motivated by the critical problem in single-cell genomics of reconstructing dynamic cellular processes from sequencing data. In particular, given a population of cells sampled from such a…

Methodology · Statistics 2025-07-16 Elodie Maignant , Tim Conrad , Christoph von Tycowicz

Trajectory inference is a critical problem in single-cell transcriptomics, which aims to reconstruct the dynamic process underlying a population of cells from sequencing data. Of particular interest is the reconstruction of differentiation…

Genomics · Quantitative Biology 2026-04-06 Elodie Maignant , Tim Conrad , Christoph von Tycowicz

Visual saliency prediction using transformers - Convolutional neural networks (CNNs) have significantly advanced computational modelling for saliency prediction. However, accurately simulating the mechanisms of visual attention in the human…

Multimedia · Computer Science 2022-06-30 Jianxun Lou , Hanhe Lin , David Marshall , Dietmar Saupe , Hantao Liu

Combining experiments with artificial intelligence algorithms, we propose a new machine learning based approach to extract the cellular force distributions from the microscope images. The full process can be divided into three steps. First,…

Current video generation models produce physically inconsistent motion that violates real-world dynamics. We propose TrajVLM-Gen, a two-stage framework for physics-aware image-to-video generation. First, we employ a Vision Language Model to…

Computer Vision and Pattern Recognition · Computer Science 2025-10-02 Fan Yang , Zhiyang Chen , Yousong Zhu , Xin Li , Jinqiao Wang

Convolutional Neural Networks (CNNs) are successfully used for the important automotive visual perception tasks including object recognition, motion and depth estimation, visual SLAM, etc. However, these tasks are typically independently…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Ganesh Sistu , Isabelle Leang , Sumanth Chennupati , Senthil Yogamani , Ciaran Hughes , Stefan Milz , Samir Rawashdeh

The cell cycle is one of the most fundamental biological processes important for understanding normal physiology and various pathologies such as cancer. Single cell RNA sequencing technologies give an opportunity to analyse the cell cycle…

Quantitative Methods · Quantitative Biology 2022-08-11 Alexander Chervov , Andrei Zinovyev

We present a multi-modal trajectory generation and selection algorithm for real-world mapless outdoor navigation in human-centered environments. Such environments contain rich features like crosswalks, grass, and curbs, which are easily…

Robotics · Computer Science 2025-05-19 Daeun Song , Jing Liang , Xuesu Xiao , Dinesh Manocha

The cellular composition of the tumor microenvironment can directly impact cancer progression and the efficacy of therapeutics. Understanding immune cell activity, the body's natural defense mechanism, in the vicinity of cancerous cells is…

Genomics · Quantitative Biology 2022-05-04 Cecily Wolfe , Yayi Feng , David Chen , Edwin Purcell , Anne Talkington , Sepideh Dolatshahi , Heman Shakeri

Cross-graph Relational Learning (CGRL) refers to the problem of predicting the strengths or labels of multi-relational tuples of heterogeneous object types, through the joint inference over multiple graphs which specify the internal…

Machine Learning · Computer Science 2016-05-09 Hanxiao Liu , Yiming Yang

Mobile devices continuously interact with cellular base stations, generating massive volumes of signaling records that provide broad coverage for understanding human mobility. However, such records offer only coarse location cues (e.g.,…

Computer Vision and Pattern Recognition · Computer Science 2026-03-30 Ruixing Zhang , Hanzhang Jiang , Leilei Sun , Liangzhe Han , Jibin Wang , Weifeng Lv

Single-cell RNA sequencing (scRNA-seq) provides unprecedented insights into cellular heterogeneity, enabling detailed analysis of complex biological systems at single-cell resolution. However, the high dimensionality and technical noise…

Genomics · Quantitative Biology 2025-09-04 Hojjat Torabi Goudarzi , Maziyar Baran Pouyan

Genomic data visualization is essential for interpretation and hypothesis generation as well as a valuable aid in communicating discoveries. Visual tools bridge the gap between algorithmic approaches and the cognitive skills of…

Genomics · Quantitative Biology 2019-11-04 Sabrina Nusrat , Theresa Harbig , Nils Gehlenborg

Realistic and diverse simulation scenarios with reactive and feasible agent behaviors can be used for validation and verification of self-driving system performance without relying on expensive and time-consuming real-world testing.…

Robotics · Computer Science 2022-04-01 Qichao Zhang , Yinfeng Gao , Yikang Zhang , Youtian Guo , Dawei Ding , Yunpeng Wang , Peng Sun , Dongbin Zhao

Rapidly creating effective visualizations using expressive grammars is challenging for users who have limited time and limited skills in statistics and data visualization. Even high-level, dedicated visualization tools often require users…

Human-Computer Interaction · Computer Science 2018-11-06 Victor Dibia , Çağatay Demiralp

In this paper, we propose a deep generative time series approach using latent temporal processes for modeling and holistically analyzing complex disease trajectories. We aim to find meaningful temporal latent representations of an…